Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1366
Official Symbol:CLDN7
Other Aliases:CEPTRL2|CPETRL2|Hs.84359|claudin-1
See related:HGNC:2049|MIM:609131|HPRD:07633
Chromosome:17
Location:17p13
Gene Description:claudin 7
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0367
ORGANISM:human
Entrez Gene ID:1366
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.9 :: -1.7 :: -1.7 :: -1.9 :: -1.3 :: 1.3
KARG Evidence 2
KARG ID:EVIM0435
ORGANISM:human
Entrez Gene ID:1366
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1 :: -1.4 :: -2.8 :: -2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
53624CBCerebellum0.9337033033370971.46144914627075
53624CTXCerebral cortex0.3587999939918520.37306222319603
53624HIPHippocampal region0.2324607223272320.26010525226593
53624HPFHippocampal formation0.2509876191616060.304354727268219
53624HYHypothalamus0.4120850563049320.425154715776443
53624LSXLateral septal complex0.4478950798511510.395287483930588
53624MBMidbrain0.8251348137855531.09200274944305
53624MYMedulla0.6199371814727780.758666396141052
53624OLFOlfactory bulb1.873803377151491.82013237476349
53624PPons0.438557446002960.65472149848938
53624PALPallidum0.3060335516929630.268387615680695
53624RHPRetrohippocampal region0.2524635493755340.336684882640839
53624sAMYStriatum-like amygdalar nuclei0.08762989193201070.0829186215996742
53624STRStriatum0.2436364144086840.24172879755497
53624STRdStriatum dorsal region0.2035343050956730.22118553519249
53624STRvStriatum ventral region0.400648117065430.35072910785675
53624THThalamus0.3200044333934780.328490316867828
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1366GO:0005198IEAFunctionstructural molecule activity
1366GO:0005923ISSComponenttight junction
1366GO:0016020IEAComponentmembrane
1366GO:0016021ISSComponentintegral to membrane
1366GO:0016338ISSProcesscalcium-independent cell-cell adhesion
1366GO:0042802ISSFunctionidentical protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7082NP_003248.2tight junction protein 1 isoform aHPRD03002
NP_001298.27082-Tight junction protein 1HPRD07633
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1366CLD7_HUMANO95471IPR006187ClaudinClaudin tight junction protein
1366CLD7_HUMANO95471IPR003548Claudin1Claudin-1
1366CLD7_HUMANO95471IPR003556Claudin14Claudin-14
1366CLD7_HUMANO95471IPR003551Claudin5Claudin-5
1366CLD7_HUMANO95471IPR003552Claudin7Claudin-7
1366CLD7_HUMANO95471IPR004031PMP22_ClaudinPMP-22/EMP/MP20 and claudin

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