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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 1385 Official Symbol: CREB1 Other Aliases: CREB|MGC9284 See related: HGNC:2345|MIM:123810|HPRD:00442 Chromosome: 2 Location: 2q34 Gene Description: cAMP responsive element binding protein 1 Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0053 ORGANISM: human Entrez Gene ID: 1385 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 12912 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 2 KARG ID: EVIC0459 ORGANISM: human Entrez Gene ID: 1385 Evidence Type: Mapping from rat Evidence ID Type: Entrez Gene Evidence ID: 81646 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 3 KARG ID: EVIM1147 ORGANISM: human Entrez Gene ID: 1385 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12716423 Addiction Drug: COCAINE Addiction Drug Detail: COCAINE ABUSE Addiction Brain Area: Ventral Tegmental Area Drug Effects: Upregulated Fold Change: - Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density Gene Ontology Gene ID GO ID Evidence GO Type GO Description 1385 GO:0003700 TAS Function transcription factor activity 1385 GO:0003712 TAS Function transcription cofactor activity 1385 GO:0005634 IEA Component nucleus 1385 GO:0005634 TAS Component nucleus 1385 GO:0006355 IEA Process regulation of transcription, DNA-dependent 1385 GO:0007165 TAS Process signal transduction 1385 GO:0043565 IEA Function sequence-specific DNA binding 1385 GO:0046983 IEA Function protein dimerization activity Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 4929 AB019433.1 Homo sapiens gene for T-cell nuclear receptor NOT (Nurr1), complete cds. BIND 315478 - 8061 NC_000011.8 Homo sapiens chromosome 11, reference assembly BIND 300875 - 1588 NC_000015.8 Homo sapiens chromosome 15, reference assembly BIND 257760 - 2908 NP_000167.1 nuclear receptor subfamily 3, group C, member 1 isoform alpha HPRD 00679 - 3651 NP_000200.1 insulin promoter factor 1, homeodomain transcription factor HPRD 02843 - 1432 NP_001306.1 mitogen-activated protein kinase 14 isoform 1 HPRD 02619 - 2963 NP_004119.1 general transcription factor IIF, polypeptide 2 (30kD subunit) HPRD 01804 - 1387 NP_004371.1 CREB binding protein HPRD 02534 - 1387 NP_004371.1 CREB binding protein BIND 296782 - 30818 NP_038462.1 Kv channel interacting protein 3 isoform 1 HPRD 05232 - 9457 NP_065228.3 activator of cAMP-responsive element modulator (CREM) in testis HPRD 05497 - 1390 NP_853549.1 cAMP responsive element modulator isoform a HPRD 00444 - 10524 NP_874369.1 HIV-1 Tat interactive protein, 60kDa isoform 1 HPRD 03245 NP_004370.1 1859 NP_001387.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1 BIND 259664 NP_004370.1 7528 NP_003394.1 YY1 transcription factor BIND 153512 NP_004370.1 155871 NP_057853.1 Tat - - NP_004370.1 155871 NP_057853.1 Tat - - NP_604391.1 - - MBF1 HPRD 00442 NP_604391.1 - - DNA HPRD 00442 NP_604391.1 3651 - Insulin promoter factor 1 HPRD 00442 NP_604391.1 2908 - Glucocorticoid receptor HPRD 00442 NP_604391.1 1390 - cAMP response element modulator HPRD 00442 NP_604391.1 2963 - TFIIF beta HPRD 00442 NP_604391.1 1387 - CREBBP HPRD 00442 NP_604391.1 8721 - Multiprotein bridging factor 1 HPRD 00442 NP_604391.1 10524 - HIV 1 Tat interacting protein HPRD 00442 NP_604391.1 9457 - ACT HPRD 00442 NP_604391.1 1432 - MAPK14 HPRD 00442 NP_604391.1 30818 - Calsenilin HPRD 00442 NP_604391.1 23373 - - BIND 181865 NP_604391.1 7067 NP_003241.2 thyroid hormone receptor, alpha isoform 2 HPRD 00442 NP_604391.1 8986 NP_003933.1 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform a HPRD 04677 NP_604391.1 8986 NP_003933.1 ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform a HPRD 00442 NP_604391.1 1387 NP_004371.1 CREB binding protein BIND 181866 NP_604391.1 2736 NP_084655.1 GLI-Kruppel family member GLI2 isoform alpha HPRD 00442 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 1385 IPR011616 bZIP_1 bZIP transcription factor, bZIP_1 1385 IPR011700 bZIP_2 Basic leucine zipper 1385 IPR001630 Leuzip_CREB cAMP response element binding (CREB) protein 1385 IPR000837 Leuzip_Fos Fos transforming protein 1385 IPR002112 Leuzip_Jun Transcription factor Jun 1385 IPR003102 pKID Coactivator CBP, pKID 1385 IPR004827 TF_bZIP Basic-leucine zipper (bZIP) transcription factor 1385 CREB1_HUMAN P16220 IPR011616 bZIP_1 bZIP transcription factor, bZIP_1 1385 CREB1_HUMAN P16220 IPR011700 bZIP_2 Basic leucine zipper 1385 CREB1_HUMAN P16220 IPR001630 Leuzip_CREB cAMP response element binding (CREB) protein 1385 CREB1_HUMAN P16220 IPR000837 Leuzip_Fos Fos transforming protein 1385 CREB1_HUMAN P16220 IPR002112 Leuzip_Jun Transcription factor Jun 1385 CREB1_HUMAN P16220 IPR003102 pKID Coactivator CBP, pKID 1385 CREB1_HUMAN P16220 IPR004827 TF_bZIP Basic-leucine zipper (bZIP) transcription factor © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.