Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1385
Official Symbol:CREB1
Other Aliases:CREB|MGC9284
See related:HGNC:2345|MIM:123810|HPRD:00442
Chromosome:2
Location:2q34
Gene Description:cAMP responsive element binding protein 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0053
ORGANISM:human
Entrez Gene ID:1385
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12912
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0459
ORGANISM:human
Entrez Gene ID:1385
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81646
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM1147
ORGANISM:human
Entrez Gene ID:1385
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1385GO:0003700TASFunctiontranscription factor activity
1385GO:0003712TASFunctiontranscription cofactor activity
1385GO:0005634IEAComponentnucleus
1385GO:0005634TASComponentnucleus
1385GO:0006355IEAProcessregulation of transcription, DNA-dependent
1385GO:0007165TASProcesssignal transduction
1385GO:0043565IEAFunctionsequence-specific DNA binding
1385GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4929AB019433.1Homo sapiens gene for T-cell nuclear receptor NOT (Nurr1), complete cds.BIND315478
-8061NC_000011.8Homo sapiens chromosome 11, reference assemblyBIND300875
-1588NC_000015.8Homo sapiens chromosome 15, reference assemblyBIND257760
-2908NP_000167.1nuclear receptor subfamily 3, group C, member 1 isoform alphaHPRD00679
-3651NP_000200.1insulin promoter factor 1, homeodomain transcription factorHPRD02843
-1432NP_001306.1mitogen-activated protein kinase 14 isoform 1HPRD02619
-2963NP_004119.1general transcription factor IIF, polypeptide 2 (30kD subunit)HPRD01804
-1387NP_004371.1CREB binding proteinHPRD02534
-1387NP_004371.1CREB binding proteinBIND296782
-30818NP_038462.1Kv channel interacting protein 3 isoform 1HPRD05232
-9457NP_065228.3activator of cAMP-responsive element modulator (CREM) in testisHPRD05497
-1390NP_853549.1cAMP responsive element modulator isoform aHPRD00444
-10524NP_874369.1HIV-1 Tat interactive protein, 60kDa isoform 1HPRD03245
NP_004370.11859NP_001387.2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1BIND259664
NP_004370.17528NP_003394.1YY1 transcription factorBIND153512
NP_004370.1155871NP_057853.1Tat--
NP_004370.1155871NP_057853.1Tat--
NP_604391.1--MBF1HPRD00442
NP_604391.1--DNAHPRD00442
NP_604391.13651-Insulin promoter factor 1HPRD00442
NP_604391.12908-Glucocorticoid receptorHPRD00442
NP_604391.11390-cAMP response element modulatorHPRD00442
NP_604391.12963-TFIIF betaHPRD00442
NP_604391.11387-CREBBPHPRD00442
NP_604391.18721-Multiprotein bridging factor 1HPRD00442
NP_604391.110524-HIV 1 Tat interacting proteinHPRD00442
NP_604391.19457-ACTHPRD00442
NP_604391.11432-MAPK14HPRD00442
NP_604391.130818-CalsenilinHPRD00442
NP_604391.123373--BIND181865
NP_604391.17067NP_003241.2thyroid hormone receptor, alpha isoform 2HPRD00442
NP_604391.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD04677
NP_604391.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD00442
NP_604391.11387NP_004371.1CREB binding proteinBIND181866
NP_604391.12736NP_084655.1GLI-Kruppel family member GLI2 isoform alphaHPRD00442
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1385IPR011616bZIP_1bZIP transcription factor, bZIP_1
1385IPR011700bZIP_2Basic leucine zipper
1385IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
1385IPR000837Leuzip_FosFos transforming protein
1385IPR002112Leuzip_JunTranscription factor Jun
1385IPR003102pKIDCoactivator CBP, pKID
1385IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor
1385CREB1_HUMANP16220IPR011616bZIP_1bZIP transcription factor, bZIP_1
1385CREB1_HUMANP16220IPR011700bZIP_2Basic leucine zipper
1385CREB1_HUMANP16220IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
1385CREB1_HUMANP16220IPR000837Leuzip_FosFos transforming protein
1385CREB1_HUMANP16220IPR002112Leuzip_JunTranscription factor Jun
1385CREB1_HUMANP16220IPR003102pKIDCoactivator CBP, pKID
1385CREB1_HUMANP16220IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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