Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1387
Official Symbol:CREBBP
Other Aliases:CBP|RSTS|RTS
See related:HGNC:2348|MIM:600140|HPRD:02534
Chromosome:16
Location:16p13.3
Gene Description:CREB binding protein (Rubinstein-Taybi syndrome)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0266
ORGANISM:human
Entrez Gene ID:1387
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12914
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12914CBCerebellum15.51509761810314.7902278900146
12914CTXCerebral cortex33.855979919433623.9775428771973
12914HIPHippocampal region31.874191284179734.4185829162598
12914HPFHippocampal formation27.662378311157226.340274810791
12914HYHypothalamus3.563528299331672.51509475708008
12914LSXLateral septal complex6.618578433990484.18752861022949
12914MBMidbrain4.846974372863774.10126733779907
12914MYMedulla10.9186801910413.0963878631592
12914OLFOlfactory bulb22.414297103881817.5711364746094
12914PPons6.248709201812746.61640405654907
12914PALPallidum5.393942356109624.50498533248901
12914RHPRetrohippocampal region20.80774688720715.241738319397
12914sAMYStriatum-like amygdalar nuclei5.666728496551513.94684958457947
12914STRStriatum7.891450405120855.39206266403198
12914STRdStriatum dorsal region7.303109645843515.00852251052856
12914STRvStriatum ventral region11.41102886199957.49269819259644
12914THThalamus13.44797992706310.319676399231
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1387GO:0001666TASProcessresponse to hypoxia
1387GO:0003700TASFunctiontranscription factor activity
1387GO:0003713IEAFunctiontranscription coactivator activity
1387GO:0003713IPIFunctiontranscription coactivator activity
1387GO:0004402IEAFunctionhistone acetyltransferase activity
1387GO:0004871TASFunctionsignal transducer activity
1387GO:0005515IPIFunctionprotein binding
1387GO:0005634IEAComponentnucleus
1387GO:0005634TASComponentnucleus
1387GO:0005737TASComponentcytoplasm
1387GO:0006355IEAProcessregulation of transcription, DNA-dependent
1387GO:0006355TASProcessregulation of transcription, DNA-dependent
1387GO:0006461TASProcessprotein complex assembly
1387GO:0007165NASProcesssignal transduction
1387GO:0008270IEAFunctionzinc ion binding
1387GO:0016740IEAFunctiontransferase activity
1387GO:0042592NASProcesshomeostasis
1387GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9314AAH30811.1KLF4 proteinHPRD03769
-3172CAA89989.1hepatocyte nuclear factor 4 alpha (HNF4alpha4)HPRD02612
-6927NP_000536.3transcription factor 1, hepaticHPRD00800
-7157NP_000537.2tumor protein p53HPRD01859
-3091NP_001521.1hypoxia-inducible factor 1, alpha subunit isoform 1HPRD04517
-3661NP_001562.1interferon regulatory factor 3HPRD04769
-1958NP_001955.1early growth response 1HPRD00549
-2308NP_002006.2forkhead box O1AHPRD00645
-3064NP_002102.2huntingtinHPRD00883
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
-4097NP_002350.1v-maf musculoaponeurotic fibrosarcoma oncogene homolog GHPRD03605
-4487NP_002439.1msh homeobox 1HPRD00866
-4605NP_002457.1MYB-related protein BHPRD03247
-4654NP_002469.2myogenic differentiation 1HPRD01166
-6195NP_002944.2ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform aHPRD03402
-7533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-1445NP_004374.1c-src tyrosine kinaseHPRD00496
-3175NP_004489.1one cut domain, family member 1HPRD05002
-3217NP_004493.1homeo box B7HPRD00850
-4776NP_004545.2cytoplasmic nuclear factor of activated T-cells 4HPRD09096
-6197NP_004577.1ribosomal protein S6 kinase, 90kDa, polypeptide 3HPRD02092
-6721NP_004590.2sterol regulatory element-binding transcription factor 2HPRD02726
-4094NP_005351.2v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform aHPRD01518
-6773NP_005410.1signal transducer and activator of transcription 2HPRD02778
-4303NP_005929.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)HPRD02070
-10370NP_006070.2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2HPRD04245
-4762NP_006152.2neurogenin 1HPRD03430
-4780NP_006155.2nuclear factor (erythroid-derived 2)-like 2HPRD02732
-10657NP_006550.1KH domain containing, RNA binding, signal transduction associated 1HPRD03926
-8092NP_008913.1cartilage paired-class homeoprotein 1HPRD03316
-6772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
-29950NP_037508.1SERTA domain containing 1HPRD15326
-9794NP_055572.1mastermind-like 1HPRD05665
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-1879NP_076870.1early B-cell factorHPRD01256
-96764NP_079107.5PRIP-interacting protein PIPMTHPRD07567
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
-122953NP_569736.1Jun dimerization proteinHPRD16360
-4773NP_775114.1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform CHPRD02730
AC007151.21958NP_001955.1early growth response 1BIND149070
NP_004371.1---BIND151760
NP_004371.1--NF-E2xHPRD02534
NP_004371.1--NFE2HPRD02534
NP_004371.1--p73-betaHPRD02534
NP_004371.1--p68HPRD02534
NP_004371.1--NPAS2HPRD02534
NP_004371.1---BIND295580
NP_004371.1-AAR06173.1Hepatitis C virus core gene, complete cdsBIND180544
NP_004371.13725-c JunHPRD02534
NP_004371.14654-Myogenic differentiation antigen 1HPRD02534
NP_004371.16195-Ribosomal S6 kinase 1HPRD02534
NP_004371.16773-STAT2HPRD02534
NP_004371.16721-SREBP2HPRD02534
NP_004371.16772-STAT1HPRD02534
NP_004371.13172-Hepatocyte nuclear factor 4 alphaHPRD02534
NP_004371.15970-NFKB3HPRD02534
NP_004371.14773-NFAT1HPRD02534
NP_004371.11958-Early growth response protein 1HPRD02534
NP_004371.110370-CITED2HPRD02534
NP_004371.15371-PMLHPRD02534
NP_004371.13091-Hypoxia inducible factor 1 alpha subunitHPRD02534
NP_004371.14487-Homeo box 7HPRD02534
NP_004371.13217-HOX B7HPRD02534
NP_004371.13661-Interferon regulatory factor 3HPRD02534
NP_004371.19314-Kruppel-like factor 4HPRD02534
NP_004371.16927-Transcription factor 1HPRD02534
NP_004371.11445-CskHPRD02534
NP_004371.13175-Hepatocyte nuclear factor 6HPRD02534
NP_004371.17157-p53HPRD02534
NP_004371.12308-FKHRHPRD02534
NP_004371.14303-AFX 1HPRD02534
NP_004371.18648-SRC1HPRD02534
NP_004371.14097-MafGHPRD02534
NP_004371.14762-Neurogenin 1HPRD02534
NP_004371.13064-HuntingtinHPRD02534
NP_004371.17533-14-3-3 EtaHPRD02534
NP_004371.14605-B MybHPRD02534
NP_004371.16197-Ribosomal protein S6 kinase alpha 3HPRD02534
NP_004371.12122-Ecotropic viral integration site1HPRD02534
NP_004371.14780-NFE2L2HPRD02534
NP_004371.196764-Nuclear receptor coactivator 6 interacting proteinHPRD02534
NP_004371.14673--BIND209203
NP_004371.14094-c-MafHPRD02534
NP_004371.19794-Mastermind like 1HPRD02534
NP_004371.110657-Sam68HPRD02534
NP_004371.18092-CART1HPRD02534
NP_004371.18202AAB92368.1Homo sapiens nuclear receptor coactivator (ACTR) mRNA, complete cds.BIND151495
NP_004371.11958AJ243425.1Homo sapiens EGR1 gene for early growth response protein 1BIND149108
NP_004371.18743NC_000003.9Homo sapiens chromosome 3BIND196793
NP_004371.16927NC_000012.9Homo sapiens chromosome 12BIND209031
NP_004371.13383NC_000019.8Homo sapiens chromosome 19, reference assemblyBIND259793
NP_004371.13172NC_000020.9Homo sapiens chromosome 20, reference assemblyBIND208329
NP_004371.12908NP_000167.1nuclear receptor subfamily 3, group C, member 1 isoform alphaHPRD02534
NP_004371.12908NP_000167.1nuclear receptor subfamily 3, group C, member 1 isoform alphaHPRD00679
NP_004371.17157NP_000537.2tumor protein p53BIND128193
NP_004371.15430NP_000928.1DNA directed RNA polymerase II polypeptide AHPRD08916
NP_004371.11487NP_001319.1C-terminal binding protein 1 isoform 1BIND295232
NP_004371.11616NP_001341.1death-associated protein 6BIND180613
NP_004371.13661NP_001562.1interferon regulatory factor 3BIND183499
NP_004371.11457NP_001886.1casein kinase II alpha 1 subunit isoform aHPRD02534
NP_004371.11457NP_001886.1casein kinase II alpha 1 subunit isoform aHPRD00277
NP_004371.11459NP_001887.1casein kinase 2, alpha prime polypeptideHPRD00279
NP_004371.11459NP_001887.1casein kinase 2, alpha prime polypeptideHPRD02534
NP_004371.13020NP_002098.1H3 histone, family 3ABIND199987
NP_004371.13064NP_002102.2huntingtinBIND128191
NP_004371.13064NP_002102.2huntingtinBIND146483
NP_004371.14255NP_002403.1O-6-methylguanine-DNA methyltransferaseHPRD02534
NP_004371.14255NP_002403.1O-6-methylguanine-DNA methyltransferaseHPRD01135
NP_004371.15629NP_002754.2prospero-related homeobox 1HPRD03330
NP_004371.15629NP_002754.2prospero-related homeobox 1HPRD02534
NP_004371.15757NP_002814.2prothymosin, alpha (gene sequence 28)HPRD01778
NP_004371.15757NP_002814.2prothymosin, alpha (gene sequence 28)HPRD02534
NP_004371.16778NP_003144.3signal transducer and activator of transcription 6HPRD02534
NP_004371.16778NP_003144.3signal transducer and activator of transcription 6HPRD03302
NP_004371.16929NP_003191.1transcription factor 3HPRD02534
NP_004371.16929NP_003191.1transcription factor 3HPRD00918
NP_004371.16938NP_003196.1transcription factor 12 isoform bBIND150980
NP_004371.16996NP_003202.2thymine-DNA glycosylaseHPRD02534
NP_004371.16996NP_003202.2thymine-DNA glycosylaseHPRD03251
NP_004371.18932NP_003918.1methyl-CpG binding domain protein 2 isoform 1HPRD02534
NP_004371.18932NP_003918.1methyl-CpG binding domain protein 2 isoform 1HPRD04647
NP_004371.14435NP_004134.1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1HPRD02534
NP_004371.14435NP_004134.1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1HPRD02146
NP_004371.11387NP_004371.1CREB binding proteinHPRD02534
NP_004371.11655NP_004387.1DEAD (Asp-Glu-Ala-Asp) box polypeptide 5HPRD01615
NP_004371.11655NP_004387.1DEAD (Asp-Glu-Ala-Asp) box polypeptide 5HPRD02534
NP_004371.12130NP_005234.1Ewing sarcoma breakpoint region 1 isoform EWSHPRD02534
NP_004371.12130NP_005234.1Ewing sarcoma breakpoint region 1 isoform EWSHPRD00592
NP_004371.14094NP_005351.2v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform aBIND57654
NP_004371.14602NP_005366.1v-myb myeloblastosis viral oncogene homologHPRD01810
NP_004371.14602NP_005366.1v-myb myeloblastosis viral oncogene homologHPRD02534
NP_004371.13297NP_005517.1heat shock transcription factor 1BIND153970
NP_004371.15928NP_005601.1retinoblastoma binding protein 4HPRD02534
NP_004371.15928NP_005601.1retinoblastoma binding protein 4HPRD04232
NP_004371.14087NP_005892.1Sma- and Mad-related protein 2BIND197281
NP_004371.14087NP_005892.1Sma- and Mad-related protein 2BIND296526
NP_004371.14088NP_005893.1MAD, mothers against decapentaplegic homolog 3BIND296525
NP_004371.14297NP_005924.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)HPRD02534
NP_004371.14297NP_005924.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)HPRD01162
NP_004371.18202NP_006525.1nuclear receptor coactivator 3HPRD03570
NP_004371.18202NP_006525.2nuclear receptor coactivator 3 isoform bBIND180396
NP_004371.110847NP_006653.1Snf2-related CBP activator proteinHPRD18103
NP_004371.16772NP_009330.1signal transducer and activator of transcription 1 isoform alphaBIND148994
NP_004371.19697NP_036420.1translocation-associated membrane protein 2HPRD16338
NP_004371.127043NP_055204.1proline-, glutamic acid-, leucine-rich protein 1HPRD02534
NP_004371.126039NP_056373.2SS18-like protein 1HPRD02534
NP_004371.126039NP_056373.2SS18-like protein 1HPRD09398
NP_004371.19325NP_057297.2thyroid hormone receptor interactor 4HPRD02534
NP_004371.19325NP_057297.2thyroid hormone receptor interactor 4HPRD05140
NP_004371.151701NP_057315.2nemo like kinaseHPRD17637
NP_004371.14928NP_057404.2nucleoporin 98kD isoform 1HPRD02534
NP_004371.14928NP_057404.2nucleoporin 98kD isoform 1HPRD03012
NP_004371.15079NP_057953.1paired box 5BIND180614
NP_004371.155728NP_060647.2Nedd4 binding protein 2HPRD02534
NP_004371.155728NP_060647.2Nedd4 binding protein 2HPRD11382
NP_004371.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND151131
NP_004371.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND296781
NP_004371.128996NP_073577.1homeodomain interacting protein kinase 2HPRD02534
NP_004371.128996NP_073577.1homeodomain interacting protein kinase 2HPRD06039
NP_004371.11879NP_076870.1early B-cell factorHPRD02534
NP_004371.179753NP_078976.2Smad nuclear interacting proteinHPRD06999
NP_004371.155809NP_277037.1transcriptional regulating factor 1 isoform 1HPRD11647
NP_004371.16772NP_644671.1signal transducer and activator of transcription 1 isoform betaBIND148999
NP_004371.16774NP_644805.1signal transducer and activator of transcription 3 isoform 1BIND183810
NP_004371.11523NP_853530.1CCAAT displacement protein isoform aHPRD00295
NP_004371.11523NP_853530.1CCAAT displacement protein isoform aHPRD02534
NP_004371.18202NP_858045.1nuclear receptor coactivator 3 isoform aBIND151185
NP_004371.110579NP_996743.1transforming, acidic coiled-coil containing protein 2 isoform bBIND196944
NP_004371.16938NP_996919.1transcription factor 12 isoform aBIND150979
NP_004371.17031NT_086913.1Homo sapiens chromosome 21 genomic contig, alternate assemblyBIND171705
NP_004371.1951475BAC02464.1polyproteinBIND182333
NP_004371.1155807NP_057852.2Vpr--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
NP_004371.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1387CBP_HUMANQ92793IPR003439ABC_transp_likeABC transporter related
1387CBP_HUMANQ92793IPR001487BromodomainBromodomain
1387CBP_HUMANQ92793IPR010303DUF902_CREBbpProtein of unknown function DUF902, CREBbp
1387CBP_HUMANQ92793IPR003101KIXCoactivator CBP, KIX
1387CBP_HUMANQ92793IPR000694PRO_richProline-rich region
1387CBP_HUMANQ92793IPR009255Trans_coactTranscriptional coactivation
1387CBP_HUMANQ92793IPR000197Znf_TAZZinc finger, TAZ-type
1387CBP_HUMANQ92793IPR000433Znf_ZZZinc finger, ZZ-type

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.