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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 1387 Official Symbol: CREBBP Other Aliases: CBP|RSTS|RTS See related: HGNC:2348|MIM:600140|HPRD:02534 Chromosome: 16 Location: 16p13.3 Gene Description: CREB binding protein (Rubinstein-Taybi syndrome) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0266 ORGANISM: human Entrez Gene ID: 1387 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 12914 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 12914 CB Cerebellum 15.515097618103 14.7902278900146 12914 CTX Cerebral cortex 33.8559799194336 23.9775428771973 12914 HIP Hippocampal region 31.8741912841797 34.4185829162598 12914 HPF Hippocampal formation 27.6623783111572 26.340274810791 12914 HY Hypothalamus 3.56352829933167 2.51509475708008 12914 LSX Lateral septal complex 6.61857843399048 4.18752861022949 12914 MB Midbrain 4.84697437286377 4.10126733779907 12914 MY Medulla 10.91868019104 13.0963878631592 12914 OLF Olfactory bulb 22.4142971038818 17.5711364746094 12914 P Pons 6.24870920181274 6.61640405654907 12914 PAL Pallidum 5.39394235610962 4.50498533248901 12914 RHP Retrohippocampal region 20.807746887207 15.241738319397 12914 sAMY Striatum-like amygdalar nuclei 5.66672849655151 3.94684958457947 12914 STR Striatum 7.89145040512085 5.39206266403198 12914 STRd Striatum dorsal region 7.30310964584351 5.00852251052856 12914 STRv Striatum ventral region 11.4110288619995 7.49269819259644 12914 TH Thalamus 13.447979927063 10.319676399231 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 1387 GO:0001666 TAS Process response to hypoxia 1387 GO:0003700 TAS Function transcription factor activity 1387 GO:0003713 IEA Function transcription coactivator activity 1387 GO:0003713 IPI Function transcription coactivator activity 1387 GO:0004402 IEA Function histone acetyltransferase activity 1387 GO:0004871 TAS Function signal transducer activity 1387 GO:0005515 IPI Function protein binding 1387 GO:0005634 IEA Component nucleus 1387 GO:0005634 TAS Component nucleus 1387 GO:0005737 TAS Component cytoplasm 1387 GO:0006355 IEA Process regulation of transcription, DNA-dependent 1387 GO:0006355 TAS Process regulation of transcription, DNA-dependent 1387 GO:0006461 TAS Process protein complex assembly 1387 GO:0007165 NAS Process signal transduction 1387 GO:0008270 IEA Function zinc ion binding 1387 GO:0016740 IEA Function transferase activity 1387 GO:0042592 NAS Process homeostasis 1387 GO:0046872 IEA Function metal ion binding Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 9314 AAH30811.1 KLF4 protein HPRD 03769 - 3172 CAA89989.1 hepatocyte nuclear factor 4 alpha (HNF4alpha4) HPRD 02612 - 6927 NP_000536.3 transcription factor 1, hepatic HPRD 00800 - 7157 NP_000537.2 tumor protein p53 HPRD 01859 - 3091 NP_001521.1 hypoxia-inducible factor 1, alpha subunit isoform 1 HPRD 04517 - 3661 NP_001562.1 interferon regulatory factor 3 HPRD 04769 - 1958 NP_001955.1 early growth response 1 HPRD 00549 - 2308 NP_002006.2 forkhead box O1A HPRD 00645 - 3064 NP_002102.2 huntingtin HPRD 00883 - 3725 NP_002219.1 v-jun avian sarcoma virus 17 oncogene homolog HPRD 01302 - 4097 NP_002350.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G HPRD 03605 - 4487 NP_002439.1 msh homeobox 1 HPRD 00866 - 4605 NP_002457.1 MYB-related protein B HPRD 03247 - 4654 NP_002469.2 myogenic differentiation 1 HPRD 01166 - 6195 NP_002944.2 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform a HPRD 03402 - 7533 NP_003396.1 tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide HPRD 00215 - 8648 NP_003734.3 nuclear receptor coactivator 1 isoform 1 HPRD 04070 - 1445 NP_004374.1 c-src tyrosine kinase HPRD 00496 - 3175 NP_004489.1 one cut domain, family member 1 HPRD 05002 - 3217 NP_004493.1 homeo box B7 HPRD 00850 - 4776 NP_004545.2 cytoplasmic nuclear factor of activated T-cells 4 HPRD 09096 - 6197 NP_004577.1 ribosomal protein S6 kinase, 90kDa, polypeptide 3 HPRD 02092 - 6721 NP_004590.2 sterol regulatory element-binding transcription factor 2 HPRD 02726 - 4094 NP_005351.2 v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform a HPRD 01518 - 6773 NP_005410.1 signal transducer and activator of transcription 2 HPRD 02778 - 4303 NP_005929.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) HPRD 02070 - 10370 NP_006070.2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 HPRD 04245 - 4762 NP_006152.2 neurogenin 1 HPRD 03430 - 4780 NP_006155.2 nuclear factor (erythroid-derived 2)-like 2 HPRD 02732 - 10657 NP_006550.1 KH domain containing, RNA binding, signal transduction associated 1 HPRD 03926 - 8092 NP_008913.1 cartilage paired-class homeoprotein 1 HPRD 03316 - 6772 NP_009330.1 signal transducer and activator of transcription 1 isoform alpha HPRD 02777 - 29950 NP_037508.1 SERTA domain containing 1 HPRD 15326 - 9794 NP_055572.1 mastermind-like 1 HPRD 05665 - 5970 NP_068810.1 v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 HPRD 01241 - 1879 NP_076870.1 early B-cell factor HPRD 01256 - 96764 NP_079107.5 PRIP-interacting protein PIPMT HPRD 07567 - 5371 NP_150241.1 promyelocytic leukemia protein isoform 1 HPRD 00023 - 122953 NP_569736.1 Jun dimerization protein HPRD 16360 - 4773 NP_775114.1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform C HPRD 02730 AC007151.2 1958 NP_001955.1 early growth response 1 BIND 149070 NP_004371.1 - - - BIND 151760 NP_004371.1 - - NF-E2x HPRD 02534 NP_004371.1 - - NFE2 HPRD 02534 NP_004371.1 - - p73-beta HPRD 02534 NP_004371.1 - - p68 HPRD 02534 NP_004371.1 - - NPAS2 HPRD 02534 NP_004371.1 - - - BIND 295580 NP_004371.1 - AAR06173.1 Hepatitis C virus core gene, complete cds BIND 180544 NP_004371.1 3725 - c Jun HPRD 02534 NP_004371.1 4654 - Myogenic differentiation antigen 1 HPRD 02534 NP_004371.1 6195 - Ribosomal S6 kinase 1 HPRD 02534 NP_004371.1 6773 - STAT2 HPRD 02534 NP_004371.1 6721 - SREBP2 HPRD 02534 NP_004371.1 6772 - STAT1 HPRD 02534 NP_004371.1 3172 - Hepatocyte nuclear factor 4 alpha HPRD 02534 NP_004371.1 5970 - NFKB3 HPRD 02534 NP_004371.1 4773 - NFAT1 HPRD 02534 NP_004371.1 1958 - Early growth response protein 1 HPRD 02534 NP_004371.1 10370 - CITED2 HPRD 02534 NP_004371.1 5371 - PML HPRD 02534 NP_004371.1 3091 - Hypoxia inducible factor 1 alpha subunit HPRD 02534 NP_004371.1 4487 - Homeo box 7 HPRD 02534 NP_004371.1 3217 - HOX B7 HPRD 02534 NP_004371.1 3661 - Interferon regulatory factor 3 HPRD 02534 NP_004371.1 9314 - Kruppel-like factor 4 HPRD 02534 NP_004371.1 6927 - Transcription factor 1 HPRD 02534 NP_004371.1 1445 - Csk HPRD 02534 NP_004371.1 3175 - Hepatocyte nuclear factor 6 HPRD 02534 NP_004371.1 7157 - p53 HPRD 02534 NP_004371.1 2308 - FKHR HPRD 02534 NP_004371.1 4303 - AFX 1 HPRD 02534 NP_004371.1 8648 - SRC1 HPRD 02534 NP_004371.1 4097 - MafG HPRD 02534 NP_004371.1 4762 - Neurogenin 1 HPRD 02534 NP_004371.1 3064 - Huntingtin HPRD 02534 NP_004371.1 7533 - 14-3-3 Eta HPRD 02534 NP_004371.1 4605 - B Myb HPRD 02534 NP_004371.1 6197 - Ribosomal protein S6 kinase alpha 3 HPRD 02534 NP_004371.1 2122 - Ecotropic viral integration site1 HPRD 02534 NP_004371.1 4780 - NFE2L2 HPRD 02534 NP_004371.1 96764 - Nuclear receptor coactivator 6 interacting protein HPRD 02534 NP_004371.1 4673 - - BIND 209203 NP_004371.1 4094 - c-Maf HPRD 02534 NP_004371.1 9794 - Mastermind like 1 HPRD 02534 NP_004371.1 10657 - Sam68 HPRD 02534 NP_004371.1 8092 - CART1 HPRD 02534 NP_004371.1 8202 AAB92368.1 Homo sapiens nuclear receptor coactivator (ACTR) mRNA, complete cds. BIND 151495 NP_004371.1 1958 AJ243425.1 Homo sapiens EGR1 gene for early growth response protein 1 BIND 149108 NP_004371.1 8743 NC_000003.9 Homo sapiens chromosome 3 BIND 196793 NP_004371.1 6927 NC_000012.9 Homo sapiens chromosome 12 BIND 209031 NP_004371.1 3383 NC_000019.8 Homo sapiens chromosome 19, reference assembly BIND 259793 NP_004371.1 3172 NC_000020.9 Homo sapiens chromosome 20, reference assembly BIND 208329 NP_004371.1 2908 NP_000167.1 nuclear receptor subfamily 3, group C, member 1 isoform alpha HPRD 02534 NP_004371.1 2908 NP_000167.1 nuclear receptor subfamily 3, group C, member 1 isoform alpha HPRD 00679 NP_004371.1 7157 NP_000537.2 tumor protein p53 BIND 128193 NP_004371.1 5430 NP_000928.1 DNA directed RNA polymerase II polypeptide A HPRD 08916 NP_004371.1 1487 NP_001319.1 C-terminal binding protein 1 isoform 1 BIND 295232 NP_004371.1 1616 NP_001341.1 death-associated protein 6 BIND 180613 NP_004371.1 3661 NP_001562.1 interferon regulatory factor 3 BIND 183499 NP_004371.1 1457 NP_001886.1 casein kinase II alpha 1 subunit isoform a HPRD 02534 NP_004371.1 1457 NP_001886.1 casein kinase II alpha 1 subunit isoform a HPRD 00277 NP_004371.1 1459 NP_001887.1 casein kinase 2, alpha prime polypeptide HPRD 00279 NP_004371.1 1459 NP_001887.1 casein kinase 2, alpha prime polypeptide HPRD 02534 NP_004371.1 3020 NP_002098.1 H3 histone, family 3A BIND 199987 NP_004371.1 3064 NP_002102.2 huntingtin BIND 128191 NP_004371.1 3064 NP_002102.2 huntingtin BIND 146483 NP_004371.1 4255 NP_002403.1 O-6-methylguanine-DNA methyltransferase HPRD 02534 NP_004371.1 4255 NP_002403.1 O-6-methylguanine-DNA methyltransferase HPRD 01135 NP_004371.1 5629 NP_002754.2 prospero-related homeobox 1 HPRD 03330 NP_004371.1 5629 NP_002754.2 prospero-related homeobox 1 HPRD 02534 NP_004371.1 5757 NP_002814.2 prothymosin, alpha (gene sequence 28) HPRD 01778 NP_004371.1 5757 NP_002814.2 prothymosin, alpha (gene sequence 28) HPRD 02534 NP_004371.1 6778 NP_003144.3 signal transducer and activator of transcription 6 HPRD 02534 NP_004371.1 6778 NP_003144.3 signal transducer and activator of transcription 6 HPRD 03302 NP_004371.1 6929 NP_003191.1 transcription factor 3 HPRD 02534 NP_004371.1 6929 NP_003191.1 transcription factor 3 HPRD 00918 NP_004371.1 6938 NP_003196.1 transcription factor 12 isoform b BIND 150980 NP_004371.1 6996 NP_003202.2 thymine-DNA glycosylase HPRD 02534 NP_004371.1 6996 NP_003202.2 thymine-DNA glycosylase HPRD 03251 NP_004371.1 8932 NP_003918.1 methyl-CpG binding domain protein 2 isoform 1 HPRD 02534 NP_004371.1 8932 NP_003918.1 methyl-CpG binding domain protein 2 isoform 1 HPRD 04647 NP_004371.1 4435 NP_004134.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HPRD 02534 NP_004371.1 4435 NP_004134.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HPRD 02146 NP_004371.1 1387 NP_004371.1 CREB binding protein HPRD 02534 NP_004371.1 1655 NP_004387.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 HPRD 01615 NP_004371.1 1655 NP_004387.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 HPRD 02534 NP_004371.1 2130 NP_005234.1 Ewing sarcoma breakpoint region 1 isoform EWS HPRD 02534 NP_004371.1 2130 NP_005234.1 Ewing sarcoma breakpoint region 1 isoform EWS HPRD 00592 NP_004371.1 4094 NP_005351.2 v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform a BIND 57654 NP_004371.1 4602 NP_005366.1 v-myb myeloblastosis viral oncogene homolog HPRD 01810 NP_004371.1 4602 NP_005366.1 v-myb myeloblastosis viral oncogene homolog HPRD 02534 NP_004371.1 3297 NP_005517.1 heat shock transcription factor 1 BIND 153970 NP_004371.1 5928 NP_005601.1 retinoblastoma binding protein 4 HPRD 02534 NP_004371.1 5928 NP_005601.1 retinoblastoma binding protein 4 HPRD 04232 NP_004371.1 4087 NP_005892.1 Sma- and Mad-related protein 2 BIND 197281 NP_004371.1 4087 NP_005892.1 Sma- and Mad-related protein 2 BIND 296526 NP_004371.1 4088 NP_005893.1 MAD, mothers against decapentaplegic homolog 3 BIND 296525 NP_004371.1 4297 NP_005924.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) HPRD 02534 NP_004371.1 4297 NP_005924.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) HPRD 01162 NP_004371.1 8202 NP_006525.1 nuclear receptor coactivator 3 HPRD 03570 NP_004371.1 8202 NP_006525.2 nuclear receptor coactivator 3 isoform b BIND 180396 NP_004371.1 10847 NP_006653.1 Snf2-related CBP activator protein HPRD 18103 NP_004371.1 6772 NP_009330.1 signal transducer and activator of transcription 1 isoform alpha BIND 148994 NP_004371.1 9697 NP_036420.1 translocation-associated membrane protein 2 HPRD 16338 NP_004371.1 27043 NP_055204.1 proline-, glutamic acid-, leucine-rich protein 1 HPRD 02534 NP_004371.1 26039 NP_056373.2 SS18-like protein 1 HPRD 02534 NP_004371.1 26039 NP_056373.2 SS18-like protein 1 HPRD 09398 NP_004371.1 9325 NP_057297.2 thyroid hormone receptor interactor 4 HPRD 02534 NP_004371.1 9325 NP_057297.2 thyroid hormone receptor interactor 4 HPRD 05140 NP_004371.1 51701 NP_057315.2 nemo like kinase HPRD 17637 NP_004371.1 4928 NP_057404.2 nucleoporin 98kD isoform 1 HPRD 02534 NP_004371.1 4928 NP_057404.2 nucleoporin 98kD isoform 1 HPRD 03012 NP_004371.1 5079 NP_057953.1 paired box 5 BIND 180614 NP_004371.1 55728 NP_060647.2 Nedd4 binding protein 2 HPRD 02534 NP_004371.1 55728 NP_060647.2 Nedd4 binding protein 2 HPRD 11382 NP_004371.1 5970 NP_068810.2 v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 BIND 151131 NP_004371.1 5970 NP_068810.2 v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 BIND 296781 NP_004371.1 28996 NP_073577.1 homeodomain interacting protein kinase 2 HPRD 02534 NP_004371.1 28996 NP_073577.1 homeodomain interacting protein kinase 2 HPRD 06039 NP_004371.1 1879 NP_076870.1 early B-cell factor HPRD 02534 NP_004371.1 79753 NP_078976.2 Smad nuclear interacting protein HPRD 06999 NP_004371.1 55809 NP_277037.1 transcriptional regulating factor 1 isoform 1 HPRD 11647 NP_004371.1 6772 NP_644671.1 signal transducer and activator of transcription 1 isoform beta BIND 148999 NP_004371.1 6774 NP_644805.1 signal transducer and activator of transcription 3 isoform 1 BIND 183810 NP_004371.1 1523 NP_853530.1 CCAAT displacement protein isoform a HPRD 00295 NP_004371.1 1523 NP_853530.1 CCAAT displacement protein isoform a HPRD 02534 NP_004371.1 8202 NP_858045.1 nuclear receptor coactivator 3 isoform a BIND 151185 NP_004371.1 10579 NP_996743.1 transforming, acidic coiled-coil containing protein 2 isoform b BIND 196944 NP_004371.1 6938 NP_996919.1 transcription factor 12 isoform a BIND 150979 NP_004371.1 7031 NT_086913.1 Homo sapiens chromosome 21 genomic contig, alternate assembly BIND 171705 NP_004371.1 951475 BAC02464.1 polyprotein BIND 182333 NP_004371.1 155807 NP_057852.2 Vpr - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - NP_004371.1 155871 NP_057853.1 Tat - - Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 1387 CBP_HUMAN Q92793 IPR003439 ABC_transp_like ABC transporter related 1387 CBP_HUMAN Q92793 IPR001487 Bromodomain Bromodomain 1387 CBP_HUMAN Q92793 IPR010303 DUF902_CREBbp Protein of unknown function DUF902, CREBbp 1387 CBP_HUMAN Q92793 IPR003101 KIX Coactivator CBP, KIX 1387 CBP_HUMAN Q92793 IPR000694 PRO_rich Proline-rich region 1387 CBP_HUMAN Q92793 IPR009255 Trans_coact Transcriptional coactivation 1387 CBP_HUMAN Q92793 IPR000197 Znf_TAZ Zinc finger, TAZ-type 1387 CBP_HUMAN Q92793 IPR000433 Znf_ZZ Zinc finger, ZZ-type © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.