Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1390
Official Symbol:CREM
Other Aliases:ICER|MGC111110|MGC17881|MGC41893|hCREM-2
See related:HGNC:2352|MIM:123812|HPRD:00444
Chromosome:10
Location:10p11.21
Gene Description:cAMP responsive element modulator
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0379
ORGANISM:human
Entrez Gene ID:1390
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -1.4 :: -1.5 :: -1.7 :: -1.5 :: -1.1
KARG Evidence 2
KARG ID:EVIM0447
ORGANISM:human
Entrez Gene ID:1390
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.3 :: -1.4 :: -2.8 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12916CBCerebellum0.8338683843612670.993739187717438
12916CTXCerebral cortex5.967278003692633.90379238128662
12916HIPHippocampal region5.747930049896244.74820709228516
12916HPFHippocampal formation8.463513374328616.55954504013062
12916HYHypothalamus3.238354682922365.30830526351929
12916LSXLateral septal complex0.00.0
12916MBMidbrain1.028073668479921.16049683094025
12916MYMedulla0.9853468537330631.34318840503693
12916OLFOlfactory bulb6.77398395538335.6285080909729
12916PPons3.022248268127444.19461297988892
12916PALPallidum3.09948849678042.70051097869873
12916RHPRetrohippocampal region15.075819969177210.5533103942871
12916sAMYStriatum-like amygdalar nuclei6.823725223541264.43600654602051
12916STRStriatum3.700938224792482.62926340103149
12916STRdStriatum dorsal region3.615543127059942.50017833709717
12916STRvStriatum ventral region3.278223514556882.79985070228577
12916THThalamus1.06029701232910.753192126750946
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1390GO:0003700IEAFunctiontranscription factor activity
1390GO:0005515IEAFunctionprotein binding
1390GO:0005634IEAComponentnucleus
1390GO:0005634NASComponentnucleus
1390GO:0006350IEAProcesstranscription
1390GO:0006355IDAProcessregulation of transcription, DNA-dependent
1390GO:0006355IEAProcessregulation of transcription, DNA-dependent
1390GO:0006355NASProcessregulation of transcription, DNA-dependent
1390GO:0007165TASProcesssignal transduction
1390GO:0008140NASFunctioncAMP response element binding protein binding
1390GO:0043565IEAFunctionsequence-specific DNA binding
1390GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6688NP_003111.1spleen focus forming virus (SFFV) proviral integration oncogene spi1HPRD01305
-6874NP_003176.1TBP-associated factor 4HPRD11797
-6908NP_003185.1TATA box binding proteinHPRD02511
-9457NP_065228.3activator of cAMP-responsive element modulator (CREM) in testisHPRD05497
NP_853549.1--hTAFII130HPRD00444
NP_853549.16688-SPI1HPRD00444
NP_853549.19457-ACTHPRD00444
NP_853549.16874-TBP associated factor 4HPRD00444
NP_853549.16908-TATA box binding proteinHPRD00444
NP_853549.130818NP_038462.1Kv channel interacting protein 3 isoform 1HPRD05232
NP_853549.130818NP_038462.1Kv channel interacting protein 3 isoform 1HPRD00444
NP_898883.1155871NP_057853.1Tat--
NP_898883.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1390IPR011616bZIP_1bZIP transcription factor, bZIP_1
1390IPR011700bZIP_2Basic leucine zipper
1390IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
1390IPR000837Leuzip_FosFos transforming protein
1390IPR002112Leuzip_JunTranscription factor Jun
1390IPR003102pKIDCoactivator CBP, pKID
1390IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor
1390CREM_HUMANQ03060IPR011616bZIP_1bZIP transcription factor, bZIP_1
1390CREM_HUMANQ03060IPR011700bZIP_2Basic leucine zipper
1390CREM_HUMANQ03060IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
1390CREM_HUMANQ03060IPR000837Leuzip_FosFos transforming protein
1390CREM_HUMANQ03060IPR002112Leuzip_JunTranscription factor Jun
1390CREM_HUMANQ03060IPR003102pKIDCoactivator CBP, pKID
1390CREM_HUMANQ03060IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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