Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1394
Official Symbol:CRHR1
Other Aliases:CRF-R|CRF1|CRFR1|CRH-R1h|CRHR|CRHR1f
See related:HGNC:2357|MIM:122561|HPRD:08830
Chromosome:17
Location:17q12-q22
Gene Description:corticotropin releasing hormone receptor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0090
ORGANISM:human
Entrez Gene ID:1394
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12921
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVID0006
ORGANISM:human
Entrez Gene ID:1394
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:122561
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12921CBCerebellum100.091.5822296142578
12921CTXCerebral cortex69.153318405151453.3535575866699
12921HIPHippocampal region17.123343944549612.9184436798096
12921HPFHippocampal formation27.216538429260321.6610326766968
12921HYHypothalamus8.981459617614757.44045400619507
12921LSXLateral septal complex10.2587409019477.5013325214386
12921MBMidbrain18.319890022277818.0465965270996
12921MYMedulla25.823521614074733.3752546310425
12921OLFOlfactory bulb78.124523162841873.4460277557373
12921PPons30.819152832031240.3017864227295
12921PALPallidum19.754127979278622.3981761932373
12921RHPRetrohippocampal region46.846820831298835.9162940979004
12921sAMYStriatum-like amygdalar nuclei31.79937982559222.5509562492371
12921STRStriatum11.18041372299198.18294525146484
12921STRdStriatum dorsal region6.467794895172124.55241417884827
12921STRvStriatum ventral region19.466614723205614.2914443016052
12921THThalamus9.5157051086425810.0327157974243
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1394GO:0004872IEAFunctionreceptor activity
1394GO:0004930IEAFunctionG-protein coupled receptor activity
1394GO:0005886TASComponentplasma membrane
1394GO:0005887TASComponentintegral to plasma membrane
1394GO:0006955TASProcessimmune response
1394GO:0007165IEAProcesssignal transduction
1394GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
1394GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
1394GO:0007190TASProcessadenylate cyclase activation
1394GO:0007565NASProcesspregnancy
1394GO:0007567TASProcessparturition
1394GO:0015056TASFunctioncorticotrophin-releasing factor receptor activity
1394GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00756
-2776NP_002063.1guanine nucleotide binding protein (G protein), q polypeptideHPRD02998
-2775NP_066268.1guanine nucleotide binding protein, alpha activating polypeptide OHPRD00757
-2778NP_536350.1guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform cHPRD00761
NP_004373.22770-G protein, alpha inhibiting 1HPRD08830
NP_004373.22775-Guanine nucleotide binding protein, alpha 'other'HPRD08830
NP_004373.22776-Guanine nucleotide binding protein G(q) alpha subunitHPRD08830
NP_004373.22778-Guanine nucleotide binding protein G(S), alpha subunitHPRD08830
NP_004373.2114131NP_444277.2urocortin 3 preproproteinHPRD12066
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1394IPR003052CRF1_rcptCorticotropin releasing factor receptor, type 1
1394IPR003053CRF2_rcptCorticotropin releasing factor receptor, type 2
1394IPR003051CRF_rcptCorticotropin releasing factor receptor
1394IPR002001Diur_hmn_rcptDiuretic hormone receptor
1394IPR000832GPCR_secretinGPCR, family 2, secretin-like
1394IPR001879hormone_rcptHormone receptor, extracellular

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