Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1409
Official Symbol:CRYAA
Other Aliases:CRYA1|HSPB4
See related:HGNC:2388|MIM:123580|HPRD:00427
Chromosome:21
Location:21q22.3
Gene Description:crystallin, alpha A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0407
ORGANISM:human
Entrez Gene ID:1409
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.1 :: -1.2 :: -1.4 :: -1.7 :: -1.4 :: -1.4
KARG Evidence 2
KARG ID:EVIM0475
ORGANISM:human
Entrez Gene ID:1409
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1 :: 1.1 :: -1.2 :: -2 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12954CBCerebellum25.821552276611319.9421643018723
12954CTXCerebral cortex17.831379115581510.0704175531864
12954HIPHippocampal region26.495761275291415.9539204835892
12954HPFHippocampal formation24.10161435604113.8157694339752
12954HYHypothalamus4.234829664230353.24262022972107
12954LSXLateral septal complex4.165676534175872.74660855531693
12954MBMidbrain9.801637321710596.06182843446732
12954MYMedulla9.293415427207957.71699488162994
12954OLFOlfactory bulb30.229636430740415.1753273010254
12954PPons8.433279693126686.25642940402031
12954PALPallidum4.378149300813672.86679044365883
12954RHPRetrohippocampal region18.462413191795310.1250723600388
12954sAMYStriatum-like amygdalar nuclei7.32850265502934.34711769223213
12954STRStriatum6.119745820760733.16566404700279
12954STRdStriatum dorsal region5.111818611621862.67881399393082
12954STRvStriatum ventral region11.53613811731344.94126784801483
12954THThalamus6.404043838381773.59463979303837
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1409GO:0005212IEAFunctionstructural constituent of eye lens
1409GO:0006457NASProcessprotein folding
1409GO:0007601IMPProcessvisual perception
1409GO:0050896IEAProcessresponse to stimulus
1409GO:0051082NRFunctionunfolded protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3315NP_001531.1heat shock 27kDa protein 1HPRD09076
-3906NP_002280.1lactalbumin, alpha- precursorHPRD01024
-1431NP_004068.2citrate synthase precursor, isoform aHPRD00349
-4284NP_036196.1major intrinsic protein of lens fiberHPRD01098
NP_000385.14284-Aquaporin 0HPRD00427
NP_000385.13906-Lactalbumin alphaHPRD00427
NP_000385.11431-Citrate synthaseHPRD00427
NP_000385.11429NP_001880.2crystallin, zetaHPRD00427
NP_000385.11429NP_001880.2crystallin, zetaHPRD00437
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1409CRYAA_HUMANP02489IPR001436Crystallin_alphaAlpha crystallin
1409CRYAA_HUMANP02489IPR003090Crystallin_NCrystallin, N-terminal
1409CRYAA_HUMANP02489IPR002068Hsp20Heat shock protein Hsp20

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