Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1410
Official Symbol:CRYAB
Other Aliases:CRYA2|CTPP2|HSPB5
See related:HGNC:2389|MIM:123590|HPRD:00428
Chromosome:11
Location:11q22.3-q23.1
Gene Description:crystallin, alpha B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0542
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25420
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0073
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:1.44 :: -0.59 :: -0.36 :: 0.42 :: -0.35 :: -0.45 :: -0.40 :: -0.11 :: 0.50 :: -0.55
KARG Evidence 3
KARG ID:EVIM0382
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1 :: -1.4 :: 1.4 :: 1.8 :: 1.2 :: 1.5
KARG Evidence 4
KARG ID:EVIM0450
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:1.7 :: 1.7 :: 1.3 :: 2.3 :: 1.6
KARG Evidence 5
KARG ID:QTL0134
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:QTL0135
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:QTL0136
ORGANISM:human
Entrez Gene ID:1410
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12955CBCerebellum71.5353164672852100.0
12955CTXCerebral cortex79.570869445800885.4023208618164
12955HIPHippocampal region65.781288146972794.0755996704102
12955HPFHippocampal formation74.685867309570395.5568466186523
12955HYHypothalamus100.0100.0
12955LSXLateral septal complex93.505088806152395.6426773071289
12955MBMidbrain100.0100.0
12955MYMedulla100.0100.0
12955OLFOlfactory bulb54.182357788085957.6096725463867
12955PPons100.0100.0
12955PALPallidum100.0100.0
12955RHPRetrohippocampal region87.974830627441496.1034317016602
12955sAMYStriatum-like amygdalar nuclei78.000343322753979.1410446166992
12955STRStriatum84.611854553222789.4056854248047
12955STRdStriatum dorsal region90.6050872802734100.0
12955STRvStriatum ventral region60.36273574829156.068977355957
12955THThalamus100.0100.0
KARG Evidence 8
KARG ID:QTL0134
Trait:cocaine related behavior
Peak:29
Peak Marker:D9Mit4
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 9
KARG ID:QTL0135
Trait:ethanol consumption
Peak:29
Peak Marker:D9Mit4
Parents:B6D2F2 (C57BL/6J x DBA/2J) and BXD Recombinant Inbred
Evidence ID:11707775; 9880656
KARG Evidence 10
KARG ID:QTL0136
Trait:Chronic ethanol withdrawal
Peak:29
Peak Marker:D9Mit4
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1410GO:0005212IEAFunctionstructural constituent of eye lens
1410GO:0005634NRComponentnucleus
1410GO:0005737NRComponentcytoplasm
1410GO:0006457NASProcessprotein folding
1410GO:0006936TASProcessmuscle contraction
1410GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
1410GO:0007601NRProcessvisual perception
1410GO:0051082NRFunctionunfolded protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1431NP_004068.2citrate synthase precursor, isoform aHPRD00349
NP_001876.15684-Proteasome subunit, alpha type 3HPRD00428
NP_001876.11431-Citrate synthaseHPRD00428
NP_001876.13315NP_001531.1heat shock 27kDa protein 1HPRD09076
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1410CRYAB_HUMANP02511IPR001436Crystallin_alphaAlpha crystallin
1410CRYAB_HUMANP02511IPR003090Crystallin_NCrystallin, N-terminal
1410CRYAB_HUMANP02511IPR002068Hsp20Heat shock protein Hsp20

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