Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1415
Official Symbol:CRYBB2
Other Aliases:CCA2|CRYB2|CRYB2A|D22S665
See related:HGNC:2398|MIM:123620|HPRD:00430
Chromosome:22
Location:22q11.2-q12.1|22q11.23
Gene Description:crystallin, beta B2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0075
ORGANISM:human
Entrez Gene ID:1415
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.76 :: -1.90 :: 0.46 :: -1.44 :: -1.39 :: -0.32 :: 1.05 :: -0.53 :: 0.48 :: -1.15
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12961CBCerebellum1.744439601898193.29912209510803
12961CTXCerebral cortex1.167089819908141.07503688335419
12961HIPHippocampal region2.224673509597782.83311462402344
12961HPFHippocampal formation1.697764992713931.96059799194336
12961HYHypothalamus0.06086614727973940.17207308113575
12961LSXLateral septal complex0.00.0
12961MBMidbrain1.147224545478822.71879482269287
12961MYMedulla0.5671375989913940.780313909053802
12961OLFOlfactory bulb1.285918116569522.0513288974762
12961PPons1.146138310432431.36883628368378
12961PALPallidum0.2065411359071730.241954520344734
12961RHPRetrohippocampal region0.8615319728851320.794784247875214
12961sAMYStriatum-like amygdalar nuclei0.06021161377429960.0588075257837772
12961STRStriatum0.569074571132660.837651669979095
12961STRdStriatum dorsal region0.8029418587684631.26260030269623
12961STRvStriatum ventral region0.2441862523555760.186535969376564
12961THThalamus0.3574980199337010.509011566638947
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1415GO:0005212IEAFunctionstructural constituent of eye lens
1415GO:0007601TASProcessvisual perception
1415GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3315NP_001531.1heat shock 27kDa protein 1HPRD09076
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1415CRBB2_HUMANP43320IPR001064CrystallinBeta and gamma crystallin

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