Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:143
Official Symbol:PARP4
Other Aliases:ADPRTL1|PARPL|PH5P|VAULT3|VPARP|p193
See related:HGNC:271|MIM:607519|HPRD:09598
Chromosome:13
Location:13q11
Gene Description:poly (ADP-ribose) polymerase family, member 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0418
ORGANISM:human
Entrez Gene ID:143
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.8 :: -1.6 :: -1.3 :: -1.5 :: -1.5 :: -1.6
KARG Evidence 2
KARG ID:EVIM0486
ORGANISM:human
Entrez Gene ID:143
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.2 :: -1.3 :: -2.6 :: -1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
143GO:0003677TASFunctionDNA binding
143GO:0003950NASFunctionNAD+ ADP-ribosyltransferase activity
143GO:0005634NASComponentnucleus
143GO:0006281NASProcessDNA repair
143GO:0006471NASProcessprotein amino acid ADP-ribosylation
143GO:0006810NASProcesstransport
143GO:0006954IMPProcessinflammatory response
143GO:0008219IMPProcesscell death
143GO:0016757IEAFunctiontransferase activity, transferring glycosyl groups
143GO:0019899IDAFunctionenzyme binding
143GO:0030529NASComponentribonucleoprotein complex
143GO:0042493NASProcessresponse to drug
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_006428.19961NP_059447.2major vault proteinHPRD05475
NP_006428.19961NP_059447.2major vault proteinHPRD09598
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
143PARP4_HUMANQ9UKK3IPR001357BRCTBRCT
143PARP4_HUMANQ9UKK3IPR001290PARPPoly(ADP-ribose) polymerase, catalytic region
143PARP4_HUMANQ9UKK3IPR013694VITVault protein inter-alpha-trypsin
143PARP4_HUMANQ9UKK3IPR013608VWA_NVWA N-terminal
143PARP4_HUMANQ9UKK3IPR002035VWF_Avon Willebrand factor, type A

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