Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1432
Official Symbol:MAPK14
Other Aliases:CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
See related:HGNC:6876|MIM:600289|HPRD:02619
Chromosome:6
Location:6p21.3-p21.2
Gene Description:mitogen-activated protein kinase 14
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0523
ORGANISM:human
Entrez Gene ID:1432
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81649
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26416CBCerebellum2.766775965690612.40150415897369
26416CTXCerebral cortex1.839208364486691.12057361006737
26416HIPHippocampal region9.244549751281743.86216688156128
26416HPFHippocampal formation8.330217599868773.99590337276459
26416HYHypothalamus0.2184749357402320.16511080507189
26416LSXLateral septal complex0.8178222775459290.594918355345726
26416MBMidbrain0.2572782114148140.262357100844383
26416MYMedulla1.052270308136940.898183226585388
26416OLFOlfactory bulb2.555259048938752.05542093515396
26416PPons0.6116855442523960.551987990736961
26416PALPallidum0.2287265285849570.320283986628056
26416RHPRetrohippocampal region7.131417989730834.13427817821503
26416sAMYStriatum-like amygdalar nuclei0.7132501453161240.620880492031574
26416STRStriatum0.5462280362844470.379019849002361
26416STRdStriatum dorsal region0.4908995591104030.295634761452675
26416STRvStriatum ventral region0.4474909454584120.389371424913406
26416THThalamus1.173079758882520.552496001124382
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1432GO:0000166IEAFunctionnucleotide binding
1432GO:0004674IEAFunctionprotein serine/threonine kinase activity
1432GO:0004707IEAFunctionMAP kinase activity
1432GO:0004708TASFunctionMAP kinase kinase activity
1432GO:0005515IPIFunctionprotein binding
1432GO:0005524IEAFunctionATP binding
1432GO:0005634ISSComponentnucleus
1432GO:0005737ISSComponentcytoplasm
1432GO:0006468IEAProcessprotein amino acid phosphorylation
1432GO:0006928TASProcesscell motility
1432GO:0006935TASProcesschemotaxis
1432GO:0006950IDAProcessresponse to stress
1432GO:0007166TASProcesscell surface receptor linked signal transduction
1432GO:0007243IDAProcessprotein kinase cascade
1432GO:0008339IDAFunctionMP kinase activity
1432GO:0016740IEAFunctiontransferase activity
1432GO:0019735TASProcessantimicrobial humoral response (sensu Vertebrata)
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2764AAH05359.1GMFB proteinHPRD03420
-8569BAA19885.1MNK1BIND195898
-3875NP_000215.1keratin 18HPRD01020
-1846NP_001385.1dual specificity phosphatase 4 isoform 1HPRD04123
-2316NP_001447.1filamin 1 (actin-binding protein-280)HPRD02060
-2005NP_001964.2ELK4 protein isoform aBIND195928
-2005NP_001964.2ELK4 protein isoform aBIND197023
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND195879
-4208NP_002388.2MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)HPRD02809
-5606NP_002747.2mitogen-activated protein kinase kinase 3 isoform ABIND208330
-1649NP_004074.2DNA-damage-inducible transcript 3HPRD00529
-1843NP_004408.1dual specificity phosphatase 1HPRD02835
-9149NP_004705.1dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform aHPRD05188
-9255NP_004748.1small inducible cytokine subfamily E, member 1HPRD04676
-4141NP_004981.2methionine-tRNA synthetaseHPRD08864
-2002NP_005220.1ELK1 proteinBIND195929
-2002NP_005220.1ELK1 proteinBIND194814
-10454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaHPRD04012
-10454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaBIND208337
-11221NP_009138.1dual specificity phosphatase 10 isoform aBIND257582
-27429NP_037379.1HtrA serine peptidase 2 isoform 1 preproproteinHPRD05919
-56940NP_064570.1dual specificity phosphatase 22HPRD13255
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
-5606NP_659732.1mitogen-activated protein kinase kinase 3 isoform CHPRD03816
NP_001306.11843-Dual specificity phosphatase 1HPRD02619
NP_001306.15606-MAP2K3HPRD02619
NP_001306.11649-CHOPHPRD02619
NP_001306.12764-Glia maturation factor betaHPRD02619
NP_001306.14208-Myocyte specific enhancer factor 2CHPRD02619
NP_001306.14141-Methionyl tRNA synthetaseHPRD02619
NP_001306.19255-Endothelial monocyte activating polypeptide 2HPRD02619
NP_001306.127429-PRSS25HPRD02619
NP_001306.127429-Serine protease 25HPRD02619
NP_001306.19149-DYRK1BHPRD02619
NP_001306.156940-Dual specificity phosphatase 22HPRD02619
NP_001306.11846-Dual specificity phosphatase 4HPRD02619
NP_001306.12316-Filamin AHPRD02619
NP_001306.13875-Keratin 18HPRD02619
NP_001306.110454-TAB1HPRD02619
NP_001306.15371-PMLHPRD02619
NP_001306.14687NP_000256.1neutrophil cytosolic factor 1BIND197018
NP_001306.11460NP_001311.3casein kinase 2, beta polypeptideHPRD02619
NP_001306.11459NP_001887.1casein kinase 2, alpha prime polypeptideHPRD00279
NP_001306.11459NP_001887.1casein kinase 2, alpha prime polypeptideHPRD02619
NP_001306.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_001306.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD02619
NP_001306.15594NP_002736.2mitogen-activated protein kinase 1HPRD02619
NP_001306.15595NP_002737.1mitogen-activated protein kinase 3HPRD03479
NP_001306.15595NP_002737.1mitogen-activated protein kinase 3HPRD02619
NP_001306.15604NP_002746.1mitogen-activated protein kinase kinase 1HPRD02619
NP_001306.15608NP_002749.2mitogen-activated protein kinase kinase 6HPRD02619
NP_001306.15608NP_002749.2mitogen-activated protein kinase kinase 6HPRD03155
NP_001306.16416NP_003001.1mitogen-activated protein kinase kinase 4HPRD03213
NP_001306.16416NP_003001.1mitogen-activated protein kinase kinase 4HPRD02619
NP_001306.18569NP_003675.2MAP kinase interacting serine/threonine kinase 1 isoform 1HPRD09468
NP_001306.18569NP_003675.2MAP kinase interacting serine/threonine kinase 1 isoform 1HPRD02619
NP_001306.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD04677
NP_001306.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD02619
NP_001306.19043NP_003962.3sperm associated antigen 9 isoform 1HPRD02619
NP_001306.19043NP_003962.3sperm associated antigen 9 isoform 1HPRD10398
NP_001306.11844NP_004409.1dual specificity phosphatase 2HPRD04348
NP_001306.11844NP_004409.1dual specificity phosphatase 2HPRD02619
NP_001306.17867NP_004626.1mitogen-activated protein kinase-activated protein kinase 3HPRD03678
NP_001306.17867NP_004626.1mitogen-activated protein kinase-activated protein kinase 3HPRD02619
NP_001306.12002NP_005220.1ELK1 proteinHPRD02407
NP_001306.12002NP_005220.1ELK1 proteinHPRD02619
NP_001306.14205NP_005578.1MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)HPRD02807
NP_001306.14205NP_005578.1MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)HPRD02619
NP_001306.14092NP_005895.1MAD, mothers against decapentaplegic homolog 7HPRD04241
NP_001306.14092NP_005895.1MAD, mothers against decapentaplegic homolog 7HPRD02619
NP_001306.110454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaHPRD02619
NP_001306.111221NP_009138.1dual specificity phosphatase 10 isoform aHPRD02619
NP_001306.111221NP_009138.1dual specificity phosphatase 10 isoform aHPRD12320
NP_001306.127347NP_037365.1serine threonine kinase 39 (STE20/SPS1 homolog, yeast)HPRD09627
NP_001306.180824NP_085143.1dual specificity phosphatase 16HPRD09525
NP_001306.180824NP_085143.1dual specificity phosphatase 16HPRD02619
NP_001306.19261NP_116584.2mitogen-activated protein kinase-activated protein kinase 2 isoform 2HPRD02619
NP_001306.19261NP_116584.2mitogen-activated protein kinase-activated protein kinase 2 isoform 2HPRD11882
NP_001306.123446NP_536856.2CDW92 antigen isoform 2HPRD16197
NP_001306.123446NP_536856.2CDW92 antigen isoform 2HPRD02619
NP_001306.15778NP_542155.1protein tyrosine phosphatase, non-receptor type 7 isoform 2HPRD01480
NP_001306.15778NP_542155.1protein tyrosine phosphatase, non-receptor type 7 isoform 2HPRD02619
NP_001306.12872NP_951009.1MAP kinase-interacting serine/threonine kinase 2 isoform 2HPRD02619
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1432IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1432IPR008349Erk_1_2_MAPKERK1/2 MAP kinase
1432IPR008351JNK_MAPKJNK MAP kinase
1432IPR003527MAP_kinMAP kinase
1432IPR008352p38_MAPKp38 MAP kinase
1432IPR000719Prot_kinaseProtein kinase
1432IPR001245Tyr_pkinaseTyrosine protein kinase
1432IPR013695WAKWall-associated kinase
1432MK14_HUMANQ16539IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1432MK14_HUMANQ16539IPR008349Erk_1_2_MAPKERK1/2 MAP kinase
1432MK14_HUMANQ16539IPR008351JNK_MAPKJNK MAP kinase
1432MK14_HUMANQ16539IPR003527MAP_kinMAP kinase
1432MK14_HUMANQ16539IPR008352p38_MAPKp38 MAP kinase
1432MK14_HUMANQ16539IPR000719Prot_kinaseProtein kinase
1432MK14_HUMANQ16539IPR001245Tyr_pkinaseTyrosine protein kinase
1432MK14_HUMANQ16539IPR013695WAKWall-associated kinase

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