Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1445
Official Symbol:CSK
Other Aliases:MGC117393
See related:HGNC:2444|MIM:124095|HPRD:00496
Chromosome:15
Location:15q23-q25
Gene Description:c-src tyrosine kinase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0076
ORGANISM:human
Entrez Gene ID:1445
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12988
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12988CBCerebellum7.09377050399787.71964311599731
12988CTXCerebral cortex16.86504554748546.89885711669922
12988HIPHippocampal region11.39110279083259.04185485839844
12988HPFHippocampal formation17.00986099243169.7455358505249
12988HYHypothalamus13.51148605346685.51410913467407
12988LSXLateral septal complex2.305694103240971.36950695514679
12988MBMidbrain17.050533294677711.9384965896606
12988MYMedulla28.647541046142626.2910556793213
12988OLFOlfactory bulb27.754772186279316.2212829589844
12988PPons24.136312484741219.8644428253174
12988PALPallidum15.15105628967298.79778385162354
12988RHPRetrohippocampal region23.75749588012710.4214458465576
12988sAMYStriatum-like amygdalar nuclei15.31496620178227.74390888214111
12988STRStriatum5.047914981842042.73515272140503
12988STRdStriatum dorsal region3.642535448074342.23872590065002
12988STRvStriatum ventral region5.581501483917242.44696927070618
12988THThalamus7.833817005157474.21305704116821
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1445GO:0000074TASProcessregulation of progression through cell cycle
1445GO:0000166IEAFunctionnucleotide binding
1445GO:0004713TASFunctionprotein-tyrosine kinase activity
1445GO:0005524IEAFunctionATP binding
1445GO:0005737TASComponentcytoplasm
1445GO:0005886IPIComponentplasma membrane
1445GO:0006468TASProcessprotein amino acid phosphorylation
1445GO:0007242IEAProcessintracellular signaling cascade
1445GO:0008022TASFunctionprotein C-terminus binding
1445GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1601NP_001334.1disabled homolog 2HPRD03139
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-3190NP_002131.2heterogeneous nuclear ribonucleoprotein K isoform aHPRD02834
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-9672NP_055469.1syndecan 3HPRD01719
-79930NP_079148.1docking protein 3HPRD16834
NP_004374.1--HSCFHPRD00496
NP_004374.1--PEPHPRD00496
NP_004374.16714-c-SrcHPRD00496
NP_004374.12534-FynHPRD00496
NP_004374.19672-Syndecan 3HPRD00496
NP_004374.15175-CD31HPRD00496
NP_004374.13190-Heterogeneous nuclear ribonucleoprotein KHPRD00496
NP_004374.11601-DAB2HPRD00496
NP_004374.15829BAA18998.1paxillin gammaHPRD03937
NP_004374.15829BAA18998.1paxillin gammaHPRD00496
NP_004374.13643NP_000199.1insulin receptorHPRD00496
NP_004374.13643NP_000199.1insulin receptorHPRD00975
NP_004374.13643NP_000199.1insulin receptorBIND197286
NP_004374.13480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00496
NP_004374.13480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00932
NP_004374.13480NP_000866.1insulin-like growth factor 1 receptor precursorBIND197285
NP_004374.15338NP_002654.2phospholipase D2HPRD03857
NP_004374.15338NP_002654.2phospholipase D2HPRD00496
NP_004374.15782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD00496
NP_004374.15782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD02513
NP_004374.15921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
NP_004374.15921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00496
NP_004374.16004NP_002919.2regulator of G-protein signalling 16BIND258573
NP_004374.11445NP_004374.1c-src tyrosine kinaseBIND258571
NP_004374.15747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
NP_004374.15747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD00496
NP_004374.127240NP_055265.1SHP2-interacting transmembrane adaptor proteinHPRD05394
NP_004374.127240NP_055265.1SHP2-interacting transmembrane adaptor proteinHPRD00496
NP_004374.155824NP_060910.2phosphoprotein associated with glycosphingolipid-enriched microdomainsHPRD05772
NP_004374.155824NP_060910.2phosphoprotein associated with glycosphingolipid-enriched microdomainsHPRD00496
NP_004374.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD00496
NP_004374.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_004374.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1445CSK_HUMANP41240IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1445CSK_HUMANP41240IPR000719Prot_kinaseProtein kinase
1445CSK_HUMANP41240IPR013625PTBTensin phosphotyrosine-binding domain
1445CSK_HUMANP41240IPR000980SH2SH2 motif
1445CSK_HUMANP41240IPR001452SH3Src homology-3
1445CSK_HUMANP41240IPR011511SH3_2Variant SH3
1445CSK_HUMANP41240IPR001245Tyr_pkinaseTyrosine protein kinase
1445CSK_HUMANP41240IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
1445CSK_HUMANP41240IPR013695WAKWall-associated kinase

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