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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 1445 Official Symbol: CSK Other Aliases: MGC117393 See related: HGNC:2444|MIM:124095|HPRD:00496 Chromosome: 15 Location: 15q23-q25 Gene Description: c-src tyrosine kinase Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0076 ORGANISM: human Entrez Gene ID: 1445 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 12988 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 12988 CB Cerebellum 7.0937705039978 7.71964311599731 12988 CTX Cerebral cortex 16.8650455474854 6.89885711669922 12988 HIP Hippocampal region 11.3911027908325 9.04185485839844 12988 HPF Hippocampal formation 17.0098609924316 9.7455358505249 12988 HY Hypothalamus 13.5114860534668 5.51410913467407 12988 LSX Lateral septal complex 2.30569410324097 1.36950695514679 12988 MB Midbrain 17.0505332946777 11.9384965896606 12988 MY Medulla 28.6475410461426 26.2910556793213 12988 OLF Olfactory bulb 27.7547721862793 16.2212829589844 12988 P Pons 24.1363124847412 19.8644428253174 12988 PAL Pallidum 15.1510562896729 8.79778385162354 12988 RHP Retrohippocampal region 23.757495880127 10.4214458465576 12988 sAMY Striatum-like amygdalar nuclei 15.3149662017822 7.74390888214111 12988 STR Striatum 5.04791498184204 2.73515272140503 12988 STRd Striatum dorsal region 3.64253544807434 2.23872590065002 12988 STRv Striatum ventral region 5.58150148391724 2.44696927070618 12988 TH Thalamus 7.83381700515747 4.21305704116821 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 1445 GO:0000074 TAS Process regulation of progression through cell cycle 1445 GO:0000166 IEA Function nucleotide binding 1445 GO:0004713 TAS Function protein-tyrosine kinase activity 1445 GO:0005524 IEA Function ATP binding 1445 GO:0005737 TAS Component cytoplasm 1445 GO:0005886 IPI Component plasma membrane 1445 GO:0006468 TAS Process protein amino acid phosphorylation 1445 GO:0007242 IEA Process intracellular signaling cascade 1445 GO:0008022 TAS Function protein C-terminus binding 1445 GO:0016740 IEA Function transferase activity Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 1601 NP_001334.1 disabled homolog 2 HPRD 03139 - 2534 NP_002028.1 protein-tyrosine kinase fyn isoform a HPRD 00655 - 3190 NP_002131.2 heterogeneous nuclear ribonucleoprotein K isoform a HPRD 02834 - 6714 NP_005408.1 proto-oncogene tyrosine-protein kinase SRC HPRD 01819 - 9672 NP_055469.1 syndecan 3 HPRD 01719 - 79930 NP_079148.1 docking protein 3 HPRD 16834 NP_004374.1 - - HSCF HPRD 00496 NP_004374.1 - - PEP HPRD 00496 NP_004374.1 6714 - c-Src HPRD 00496 NP_004374.1 2534 - Fyn HPRD 00496 NP_004374.1 9672 - Syndecan 3 HPRD 00496 NP_004374.1 5175 - CD31 HPRD 00496 NP_004374.1 3190 - Heterogeneous nuclear ribonucleoprotein K HPRD 00496 NP_004374.1 1601 - DAB2 HPRD 00496 NP_004374.1 5829 BAA18998.1 paxillin gamma HPRD 03937 NP_004374.1 5829 BAA18998.1 paxillin gamma HPRD 00496 NP_004374.1 3643 NP_000199.1 insulin receptor HPRD 00496 NP_004374.1 3643 NP_000199.1 insulin receptor HPRD 00975 NP_004374.1 3643 NP_000199.1 insulin receptor BIND 197286 NP_004374.1 3480 NP_000866.1 insulin-like growth factor 1 receptor precursor HPRD 00496 NP_004374.1 3480 NP_000866.1 insulin-like growth factor 1 receptor precursor HPRD 00932 NP_004374.1 3480 NP_000866.1 insulin-like growth factor 1 receptor precursor BIND 197285 NP_004374.1 5338 NP_002654.2 phospholipase D2 HPRD 03857 NP_004374.1 5338 NP_002654.2 phospholipase D2 HPRD 00496 NP_004374.1 5782 NP_002826.2 protein tyrosine phosphatase, non-receptor type 12 HPRD 00496 NP_004374.1 5782 NP_002826.2 protein tyrosine phosphatase, non-receptor type 12 HPRD 02513 NP_004374.1 5921 NP_002881.1 RAS p21 protein activator 1 isoform 1 HPRD 00745 NP_004374.1 5921 NP_002881.1 RAS p21 protein activator 1 isoform 1 HPRD 00496 NP_004374.1 6004 NP_002919.2 regulator of G-protein signalling 16 BIND 258573 NP_004374.1 1445 NP_004374.1 c-src tyrosine kinase BIND 258571 NP_004374.1 5747 NP_005598.3 PTK2 protein tyrosine kinase 2 isoform b HPRD 02859 NP_004374.1 5747 NP_005598.3 PTK2 protein tyrosine kinase 2 isoform b HPRD 00496 NP_004374.1 27240 NP_055265.1 SHP2-interacting transmembrane adaptor protein HPRD 05394 NP_004374.1 27240 NP_055265.1 SHP2-interacting transmembrane adaptor protein HPRD 00496 NP_004374.1 55824 NP_060910.2 phosphoprotein associated with glycosphingolipid-enriched microdomains HPRD 05772 NP_004374.1 55824 NP_060910.2 phosphoprotein associated with glycosphingolipid-enriched microdomains HPRD 00496 NP_004374.1 6464 NP_892113.1 SHC (Src homology 2 domain containing) transforming protein 1 HPRD 00496 NP_004374.1 6464 NP_892113.1 SHC (Src homology 2 domain containing) transforming protein 1 HPRD 02780 NP_004374.1 155871 NP_057853.1 Tat - - Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 1445 CSK_HUMAN P41240 IPR013543 CaMKII_AD Calcium/calmodulin dependent protein kinase II, association-domain 1445 CSK_HUMAN P41240 IPR000719 Prot_kinase Protein kinase 1445 CSK_HUMAN P41240 IPR013625 PTB Tensin phosphotyrosine-binding domain 1445 CSK_HUMAN P41240 IPR000980 SH2 SH2 motif 1445 CSK_HUMAN P41240 IPR001452 SH3 Src homology-3 1445 CSK_HUMAN P41240 IPR011511 SH3_2 Variant SH3 1445 CSK_HUMAN P41240 IPR001245 Tyr_pkinase Tyrosine protein kinase 1445 CSK_HUMAN P41240 IPR008266 Tyr_pkinase_AS Tyrosine protein kinase, active site 1445 CSK_HUMAN P41240 IPR013695 WAK Wall-associated kinase © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.