Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:147
Official Symbol:ADRA1B
Other Aliases:ADRA1|ALPHA1BAR
See related:HGNC:278|MIM:104220|HPRD:00080
Chromosome:5
Location:5q23-q32
Gene Description:adrenergic, alpha-1B-, receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0178
ORGANISM:human
Entrez Gene ID:147
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
KARG Evidence 2
KARG ID:QTL0178
Trait:high-dose ethanol actions
Peak:19
Peak Marker:GABRA1
Parents:LS x SS intercross
Evidence ID:9023306
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
147GO:0001584IEAFunctionrhodopsin-like receptor activity
147GO:0004872IEAFunctionreceptor activity
147GO:0004935IEAFunctionadrenoceptor activity
147GO:0004937TASFunctionalpha1-adrenergic receptor activity
147GO:0005887TASComponentintegral to plasma membrane
147GO:0007165IEAProcesssignal transduction
147GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
147GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
147GO:0007243TASProcessprotein kinase cascade
147GO:0007267TASProcesscell-cell signaling
147GO:0007275TASProcessdevelopment
147GO:0008283TASProcesscell proliferation
147GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000670.1--G alpha(q/11)HPRD00080
NP_000670.1--m2 subunit of the AP2 clathrin adaptorHPRD00080
NP_000670.16295NP_000532.1S-arrestinHPRD00080
NP_000670.16295NP_000532.1S-arrestinHPRD01625
NP_000670.12767NP_002058.1guanine nucleotide binding protein (G protein), alpha 11 (Gq class)HPRD00759
NP_000670.12767NP_002058.1guanine nucleotide binding protein (G protein), alpha 11 (Gq class)HPRD00080
NP_000670.16772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
147ADA1B_HUMANP35368IPR0022325HT6_rcpt5-Hydroxytryptamine 6 receptor
147ADA1B_HUMANP35368IPR001115Adrene_rcpt_A1BAdrenergic receptor, alpha-1B
147ADA1B_HUMANP35368IPR002233Adrnrgc_rcptAdrenergic receptor
147ADA1B_HUMANP35368IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
147ADA1B_HUMANP35368IPR000611NPY_rcptNeuropeptide Y receptor

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