Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1476
Official Symbol:CSTB
Other Aliases:CST6|EPM1|PME|STFB|cystatin B
See related:HGNC:2482|MIM:601145|HPRD:03091
Chromosome:21
Location:21q22.3
Gene Description:cystatin B (stefin B)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0484
ORGANISM:human
Entrez Gene ID:1476
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25308
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0250
ORGANISM:human
Entrez Gene ID:1476
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13014CBCerebellum25.813153266906724.9160976409912
13014CTXCerebral cortex4.394742846488952.91780859231949
13014HIPHippocampal region14.31113529205327.27020967006683
13014HPFHippocampal formation11.63250553607946.08375334739685
13014HYHypothalamus5.314884185791023.6432032585144
13014LSXLateral septal complex1.906151413917541.28078943490982
13014MBMidbrain9.943757176399237.50268268585205
13014MYMedulla26.299427032470722.2309522628784
13014OLFOlfactory bulb7.104395627975464.02522015571594
13014PPons17.358413696289114.3573322296143
13014PALPallidum6.033971786499024.85033512115479
13014RHPRetrohippocampal region6.524198532104494.31747990846634
13014sAMYStriatum-like amygdalar nuclei2.894509315490722.10327386856079
13014STRStriatum1.979238510131841.35907033085823
13014STRdStriatum dorsal region1.843435406684881.30246379971504
13014STRvStriatum ventral region1.993524789810181.19643369317055
13014THThalamus5.135625243186953.41652345657349
KARG Evidence 3
KARG ID:QTL0250
Trait:Chronic ethanol withdrawal
Peak:4
Peak Marker:D19Mit109
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1476GO:0004869IEAFunctioncysteine protease inhibitor activity
1476GO:0005634IEAComponentnucleus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1509NP_001900.1cathepsin D preproproteinHPRD00291
-1514NP_001903.1cathepsin L preproproteinHPRD00293
-1512NP_004381.2cathepsin H isoform a preproproteinHPRD00288
-1508NP_680090.1cathepsin B preproproteinHPRD00287
NP_000091.11509-Cathepsin DHPRD03091
NP_000091.11508-Cathepsin BHPRD03091
NP_000091.11512-Cathepsin HHPRD03091
NP_000091.11514-Cathepsin LHPRD03091
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1476CYTB_HUMANP04080IPR000010Prot_inh_cystatProteinase inhibitor I25, cystatin
1476CYTB_HUMANP04080IPR001713Prot_inh_stefinAProteinase inhibitor I25A, stefin A

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