Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1490
Official Symbol:CTGF
Other Aliases:CCN2|IGFBP8|MGC102839|NOV2
See related:HGNC:2500|MIM:121009|HPRD:00412
Chromosome:6
Location:6q23.1
Gene Description:connective tissue growth factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0293
ORGANISM:human
Entrez Gene ID:1490
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14219
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14219CBCerebellum8.3463506499926211.0128494501114
14219CTXCerebral cortex13.608031431833918.443977355957
14219HIPHippocampal region5.130393266677868.66616376241048
14219HPFHippocampal formation9.9956752459208219.8323176701864
14219HYHypothalamus2.695602019627893.11359810829163
14219LSXLateral septal complex5.266788721084598.0396416982015
14219MBMidbrain5.784024596214297.39995694160461
14219MYMedulla6.746375401814788.21276505788167
14219OLFOlfactory bulb21.277061462402327.9570579528809
14219PPons5.977286974589039.72276631991068
14219PALPallidum2.757424761851632.94777431090673
14219RHPRetrohippocampal region17.76285107930534.4213511149089
14219sAMYStriatum-like amygdalar nuclei3.301691641410193.2718821366628
14219STRStriatum8.1830646197001114.2829494476318
14219STRdStriatum dorsal region10.548771540323919.9813305536906
14219STRvStriatum ventral region3.323022961616523.81515471140544
14219THThalamus3.388917982578283.67575110991796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1490GO:0001558IEAProcessregulation of cell growth
1490GO:0005515IEAFunctionprotein binding
1490GO:0005520TASFunctioninsulin-like growth factor binding
1490GO:0005578TASComponentextracellular matrix (sensu Metazoa)
1490GO:0005615NRComponentextracellular space
1490GO:0005625NRComponentsoluble fraction
1490GO:0005886TASComponentplasma membrane
1490GO:0006260IEAProcessDNA replication
1490GO:0006928NRProcesscell motility
1490GO:0007155IEAProcesscell adhesion
1490GO:0008201IEAFunctionheparin binding
1490GO:0008544TASProcessepidermis development
1490GO:0009611TASProcessresponse to wounding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4035NP_002323.1low density lipoprotein-related protein 1HPRD00138
NP_001892.14035-Low density lipoprotein receptor-related protein 1HPRD00412
NP_001892.17042AAA50404.1Human transforming growth factor-beta-2 mRNA, and translated productsHPRD00412
NP_001892.17042AAA50404.1Human transforming growth factor-beta-2 mRNA, and translated productsHPRD01828
NP_001892.17040NP_000651.1transforming growth factor, beta 1HPRD00412
NP_001892.17040NP_000651.1transforming growth factor, beta 1HPRD01821
NP_001892.17043NP_003230.1transforming growth factor, beta 3HPRD00412
NP_001892.17043NP_003230.1transforming growth factor, beta 3HPRD01829
NP_001892.17422NP_003367.2vascular endothelial growth factorHPRD00412
NP_001892.17422NP_003367.2vascular endothelial growth factorHPRD01889
NP_001892.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD02767
NP_001892.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD00412
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1490CTGF_HUMANP29279IPR006208Cys_knotCystine knot
1490CTGF_HUMANP29279IPR006207Cys_knot_CCystine knot, C-terminal
1490CTGF_HUMANP29279IPR000867IGFBP_likeInsulin-like growth factor-binding protein, IGFBP
1490CTGF_HUMANP29279IPR000884TSP1Thrombospondin, type I
1490CTGF_HUMANP29279IPR001007VWF_Cvon Willebrand factor, type C

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