Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1493
Official Symbol:CTLA4
Other Aliases:CD|CD152|CELIAC3|CTLA-4|GSE|IDDM12
See related:HGNC:2505|MIM:123890|HPRD:00474
Chromosome:2
Location:2q33
Gene Description:cytotoxic T-lymphocyte-associated protein 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0947
ORGANISM:human
Entrez Gene ID:1493
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12477CBCerebellum0.3781480863690380.633326828479767
12477CTXCerebral cortex0.5110599845647810.48056448996067
12477HIPHippocampal region0.2824757546186450.409349597990513
12477HPFHippocampal formation0.2594210207462310.347642049193382
12477HYHypothalamus0.4296113383024930.302842937409878
12477LSXLateral septal complex0.1574570834636690.195877358317375
12477MBMidbrain0.3349313661456110.482468292117119
12477MYMedulla0.2565327696502210.358324989676476
12477OLFOlfactory bulb0.7164428383111950.748725444078445
12477PPons0.4309577047824860.396155077964067
12477PALPallidum0.1928111482411620.195537582039833
12477RHPRetrohippocampal region0.2098820880055430.266764760017395
12477sAMYStriatum-like amygdalar nuclei0.5232491847127680.389245301485062
12477STRStriatum0.2339446172118190.284568428993225
12477STRdStriatum dorsal region0.1851185970008370.209164798259735
12477STRvStriatum ventral region0.2828536648303270.508343905210495
12477THThalamus0.2620628997683530.239568263292313
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1493GO:0005887TASComponentintegral to plasma membrane
1493GO:0006955IEAProcessimmune response
1493GO:0006955TASProcessimmune response
1493GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-3717NP_004963.1Janus kinase 2HPRD00993
-5525NP_006234.1protein phosphatase 2, regulatory subunit B (B56), alpha isoformHPRD03384
NP_005205.25295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00474
NP_005205.22534-FynHPRD00474
NP_005205.23717-Janus kinase 2HPRD00474
NP_005205.25525-Protein phosphatase 2, regulatory subunit B (B56), alphaHPRD00474
NP_005205.24067NP_002341.1v-yes-1 Yamaguchi sarcoma viral related oncogene homologHPRD01301
NP_005205.24067NP_002341.1v-yes-1 Yamaguchi sarcoma viral related oncogene homologHPRD00474
NP_005205.25781NP_002825.2protein tyrosine phosphatase, non-receptor type 11 isoform 1HPRD00474
NP_005205.23717NP_004963.1Janus kinase 2BIND196461
NP_005205.23932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD00474
NP_005205.23932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
NP_005205.28907NP_115882.1adaptor-related protein complex 1, mu 1 subunitHPRD04639
NP_005205.28907NP_115882.1adaptor-related protein complex 1, mu 1 subunitHPRD00474
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1493CTLA4_HUMANP16410IPR008096CTLA4Cytotoxic T-lymphocyte antigen 4
1493CTLA4_HUMANP16410IPR013106V-setImmunoglobulin V-set

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