Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1499
Official Symbol:CTNNB1
Other Aliases:CTNNB
See related:HGNC:2514|MIM:116806|HPRD:00286
Chromosome:3
Location:3p21
Gene Description:catenin (cadherin-associated protein), beta 1, 88kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0005
ORGANISM:human
Entrez Gene ID:1499
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12387
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0372
ORGANISM:human
Entrez Gene ID:1499
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:84353
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12387CBCerebellum50.110416412353592.0722465515137
12387CTXCerebral cortex95.925197601318493.8061447143555
12387HIPHippocampal region90.7728881835938100.0
12387HPFHippocampal formation97.4025459289551100.0
12387HYHypothalamus93.202884674072383.4274864196777
12387LSXLateral septal complex100.090.0185890197754
12387MBMidbrain82.052082061767684.0722999572754
12387MYMedulla60.759107589721769.7951126098633
12387OLFOlfactory bulb100.0100.0
12387PPons57.654129028320362.8911380767822
12387PALPallidum84.595851898193486.7285385131836
12387RHPRetrohippocampal region100.0100.0
12387sAMYStriatum-like amygdalar nuclei89.846611022949282.999095916748
12387STRStriatum80.650163650512767.2361145019531
12387STRdStriatum dorsal region62.684970855712950.5636672973633
12387STRvStriatum ventral region100.091.8820381164551
12387THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1499GO:0003713NASFunctiontranscription coactivator activity
1499GO:0004871NASFunctionsignal transducer activity
1499GO:0005198IEAFunctionstructural molecule activity
1499GO:0005515IPIFunctionprotein binding
1499GO:0005634TASComponentnucleus
1499GO:0005856TASComponentcytoskeleton
1499GO:0005911NRComponentintercellular junction
1499GO:0006350IEAProcesstranscription
1499GO:0006357NRProcessregulation of transcription from RNA polymerase II promoter
1499GO:0007155IEAProcesscell adhesion
1499GO:0016055IEAProcessWnt receptor signaling pathway
1499GO:0016328IDAComponentlateral plasma membrane
1499GO:0030521NASProcessandrogen receptor signaling pathway
1499GO:0045893NASProcesspositive regulation of transcription, DNA-dependent
1499GO:0050681NASFunctionandrogen receptor binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5310NP_000287.2polycystin 1 isoform 2 precursorHPRD03203
-6927NP_000536.3transcription factor 1, hepaticHPRD00800
-2274NP_001441.2four and a half LIM domains 2HPRD04026
-3551NP_001547.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaHPRD04462
-5795NP_002834.2protein tyrosine phosphatase, receptor type, J precursorHPRD02955
-6597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4HPRD04459
-7430NP_003370.2villin 2HPRD00475
-8312NP_003493.1axin 1 isoform aHPRD04819
-8826NP_003861.1IQ motif containing GTPase activating protein 1HPRD04541
-1855NP_004412.1dishevelled 1HPRD03220
-1855NP_004412.1dishevelled 1HPRD03220
-1857NP_004414.2dishevelled 3HPRD03222
-5318NP_004563.1plakophilin 2 isoform 2bHPRD04177
-8313NP_004646.1axin 2HPRD04935
-2516NP_004950.2nuclear receptor subfamily 5, group A, member 1HPRD01702
-4089NP_005350.1MAD, mothers against decapentaplegic homolog 4HPRD02995
-5784NP_005392.2protein tyrosine phosphatase, non-receptor type 14HPRD04402
-6907NP_005638.1transducin beta-like 1XHPRD02183
-10076NP_005695.2protein tyrosine phosphatase, receptor type, U isoform 3 precursorHPRD03908
-10076NP_005695.2protein tyrosine phosphatase, receptor type, U isoform 3 precursorHPRD03908
-10672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-50649NP_056135.2Rho guanine nucleotide exchange factor 4 isoform aHPRD05559
-26108NP_056432.1pygopus homolog 1HPRD06064
-55591NP_060069.2transmembrane protein vezatinHPRD11671
-2898NP_068775.1glutamate receptor 6 isoform 1 precursorHPRD00692
-83439NP_112573.1HMG-box transcription factor TCF-3HPRD06874
-140825NP_542787.1neuralized-like protein 2HPRD16353
NP_001895.1--Catenin alphaHPRD00286
NP_001895.1--APCLHPRD00286
NP_001895.1--Pontin52HPRD00286
NP_001895.1--FAMHPRD00286
NP_001895.1--MAGI-1bHPRD00286
NP_001895.1--p35HPRD00286
NP_001895.1--DuplinHPRD00286
NP_001895.1--S-SCAMHPRD00286
NP_001895.1--ICATHPRD00286
NP_001895.1--LMW-PTPHPRD00286
NP_001895.1---BIND262092
NP_001895.17430-EzrinHPRD00286
NP_001895.15787-Receptor type protein tyrosine phosphatase betaHPRD00286
NP_001895.15803-Protein tyrosine phosphatase, receptor zeta 1HPRD00286
NP_001895.11855-Dishevelled 1HPRD00286
NP_001895.11857-Dishevelled 3HPRD00286
NP_001895.150649-Rho guanine nucleotide exchange factor 4HPRD00286
NP_001895.18313-Axin 2HPRD00286
NP_001895.110672-Guanine nucleotide binding protein, alpha 13HPRD00286
NP_001895.16927-Transcription factor 1HPRD00286
NP_001895.183439-Transcription factor 7-like 1HPRD00286
NP_001895.15310-Polycystin 1HPRD00286
NP_001895.16907-TBL1XHPRD00286
NP_001895.13551-IKK betaHPRD00286
NP_001895.16597-SMARCA4HPRD00286
NP_001895.15318-Plakophilin 2HPRD00286
NP_001895.126108-PYGO1HPRD00286
NP_001895.14089-SMAD4HPRD00286
NP_001895.18312-AXIN1HPRD00286
NP_001895.12898-Glutamate receptor, ionotropic kainate 2HPRD00286
NP_001895.15795-Protein tyrosine phosphatase receptor, typeJHPRD00286
NP_001895.15770-PTPN1HPRD00286
NP_001895.12274-FHL2HPRD00286
NP_001895.110076-Protein tyrosine phosphatase, receptor type, UHPRD00286
NP_001895.12516-Nuclear receptor subfamily 5, group A, member 1HPRD00286
NP_001895.125776-CHIBBYHPRD00286
NP_001895.15784-Protein-tyrosine phosphatase pezHPRD00286
NP_001895.18945--BIND257631
NP_001895.12309--BIND258460
NP_001895.12494AAD03155.1Human alpha1-fetoprotein transcription factor (hFTF) mRNA, complete cdsBIND153615
NP_001895.191653AAQ88694.1BOCHPRD12280
NP_001895.13485NC_000002.9Homo sapiens chromosome 2BIND295117
NP_001895.16446NC_000006.9Homo sapiens chromosome 6BIND295118
NP_001895.126281NC_000008.9Homo sapiens chromosome 8, reference assemblyBIND197198
NP_001895.122943NC_000010.8Homo sapiens chromosome 10BIND197196
NP_001895.13732NC_000011.8Homo sapiens chromosome 11, reference assemblyBIND262095
NP_001895.18313NC_000017.9Homo sapiens chromosome 17, reference assemblyBIND215035
NP_001895.17031NC_000021.7Homo sapiens chromosome 21, reference assemblyBIND215037
NP_001895.15663NP_000012.1presenilin 1BIND55042
NP_001895.12099NP_000116.1estrogen receptor 1BIND215039
NP_001895.15310NP_000287.2polycystin 1 isoform 2 precursorBIND185074
NP_001895.15175NP_000433.2platelet/endothelial cell adhesion molecule (CD31 antigen)HPRD00286
NP_001895.11825NP_001932.1desmocollin 3 isoform Dsc3a preproproteinHPRD02604
NP_001895.11825NP_001932.1desmocollin 3 isoform Dsc3a preproproteinHPRD00286
NP_001895.12308NP_002006.2forkhead box O1ABIND258461
NP_001895.12932NP_002084.2glycogen synthase kinase 3 betaBIND262069
NP_001895.15792NP_002831.1protein tyrosine phosphatase, receptor type, F isoform 1 precursorHPRD00286
NP_001895.15792NP_002831.1protein tyrosine phosphatase, receptor type, F isoform 1 precursorHPRD01552
NP_001895.15796NP_002835.2protein tyrosine phosphatase, receptor type, K precursorHPRD03968
NP_001895.15796NP_002835.2protein tyrosine phosphatase, receptor type, K precursorHPRD00286
NP_001895.16925NP_003190.1transcription factor 4 isoform bHPRD03780
NP_001895.16925NP_003190.1transcription factor 4 isoform bHPRD00286
NP_001895.16929NP_003191.1transcription factor 3HPRD00918
NP_001895.16929NP_003191.1transcription factor 3HPRD00286
NP_001895.18826NP_003861.1IQ motif containing GTPase activating protein 1HPRD00286
NP_001895.14790NP_003989.2nuclear factor kappa-B, subunit 1BIND259802
NP_001895.11739NP_004078.1synapse-associated protein 97HPRD00286
NP_001895.11739NP_004078.1synapse-associated protein 97HPRD03007
NP_001895.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
NP_001895.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD00286
NP_001895.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD01281
NP_001895.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD00286
NP_001895.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01822
NP_001895.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD00286
NP_001895.18239NP_004643.2ubiquitin specific protease 9, X-linked isoform 1HPRD02091
NP_001895.19231NP_004738.2discs large homolog 5HPRD04972
NP_001895.19231NP_004738.2discs large homolog 5HPRD00286
NP_001895.11956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00579
NP_001895.11956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00286
NP_001895.110297NP_005874.1adenomatosis polyposis coli 2HPRD09802
NP_001895.110297NP_005874.1adenomatosis polyposis coli 2HPRD00286
NP_001895.14087NP_005892.1Sma- and Mad-related protein 2HPRD03221
NP_001895.14087NP_005892.1Sma- and Mad-related protein 2HPRD00286
NP_001895.14088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD04380
NP_001895.14088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD00286
NP_001895.14303NP_005929.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)BIND258463
NP_001895.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD03031
NP_001895.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD00286
NP_001895.110856NP_006657.1RuvB-like 2BIND262098
NP_001895.19863NP_036433.2membrane associated guanylate kinase, WW and PDZ domain containing 2HPRD16212
NP_001895.125794NP_036550.1fascin 2HPRD00286
NP_001895.125794NP_036550.1fascin 2HPRD06366
NP_001895.129119NP_037398.1catenin, alpha 3HPRD00286
NP_001895.129119NP_037398.1catenin, alpha 3HPRD09639
NP_001895.130851NP_055419.1Tax1 (human T-cell leukemia virus type I) binding protein 3HPRD18160
NP_001895.125776NP_056188.1PKD2 interactor, golgi and endoplasmic reticulum associated 1 isoform aHPRD09676
NP_001895.151176NP_057353.1lymphoid enhancer binding factor-1HPRD01075
NP_001895.151176NP_057353.1lymphoid enhancer binding factor-1HPRD00286
NP_001895.151176NP_057353.1lymphoid enhancer binding factor-1BIND183681
NP_001895.150937NP_058648.2surface glycoprotein, Ig superfamily memberHPRD16372
NP_001895.155966NP_061324.1transmembrane protein SHREW1HPRD15339
NP_001895.156998NP_064633.1catenin, beta interacting protein 1HPRD09677
NP_001895.156998NP_064633.1catenin, beta interacting protein 1HPRD00286
NP_001895.164403NP_071923.2cadherin-like 24 isoform 1HPRD13019
NP_001895.16934NP_110383.1transcription factor 7-like 2 (T-cell specific, HMG-box)HPRD03751
NP_001895.16934NP_110383.1transcription factor 7-like 2 (T-cell specific, HMG-box)HPRD00286
NP_001895.16934NP_110383.1transcription factor 7-like 2 (T-cell specific, HMG-box)BIND151819
NP_001895.16934NP_110383.1transcription factor 7-like 2 (T-cell specific, HMG-box)BIND183680
NP_001895.18945NP_378663.1beta-transducin repeat containing protein isoform 1HPRD00286
NP_001895.18945NP_378663.1beta-transducin repeat containing protein isoform 1HPRD04596
NP_001895.15295NP_852664.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1HPRD00286
NP_001895.14582NP_877418.1mucin 1, transmembraneBIND134113
NP_001895.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD01152
NP_001895.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD00286
NP_001895.1155945NP_057855.1Vpu--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1499CTNB1_HUMANP35222IPR000225ArmadilloArmadillo
1499CTNB1_HUMANP35222IPR000357HEATHEAT

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