Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1501
Official Symbol:CTNND2
Other Aliases:GT24|NPRAP
See related:HGNC:2516|MIM:604275|HPRD:09181
Chromosome:5
Location:5p15.2
Gene Description:catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0427
ORGANISM:human
Entrez Gene ID:1501
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:114028
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0116
ORGANISM:human
Entrez Gene ID:1501
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:0.74 :: 1.35 :: -0.05 :: -0.08 :: -1.23 :: -1.39 :: -1.49
KARG Evidence 3
KARG ID:HOT0237
ORGANISM:human
Entrez Gene ID:1501
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18163CBCerebellum15.651570320129419.5070400238037
18163CTXCerebral cortex77.825096130371169.3875961303711
18163HIPHippocampal region27.753602981567438.1543388366699
18163HPFHippocampal formation43.135787963867250.4737014770508
18163HYHypothalamus10.72696399688729.3773193359375
18163LSXLateral septal complex3.302969455718992.77698278427124
18163MBMidbrain12.286462783813512.8504114151001
18163MYMedulla14.959763526916517.2959499359131
18163OLFOlfactory bulb51.660808563232444.733283996582
18163PPons7.800290107727058.83765697479248
18163PALPallidum23.726301193237325.5125560760498
18163RHPRetrohippocampal region69.432914733886768.5361862182617
18163sAMYStriatum-like amygdalar nuclei24.06531524658220.0242042541504
18163STRStriatum34.364242553710926.5061740875244
18163STRdStriatum dorsal region44.09758377075234.4496383666992
18163STRvStriatum ventral region20.409605026245114.1998167037964
18163THThalamus35.092487335205130.6709575653076
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1501GO:0005198IEAFunctionstructural molecule activity
1501GO:0005515IEAFunctionprotein binding
1501GO:0005634IEAComponentnucleus
1501GO:0005737TASComponentcytoplasm
1501GO:0005856IEAComponentcytoskeleton
1501GO:0006350IEAProcesstranscription
1501GO:0006355IEAProcessregulation of transcription, DNA-dependent
1501GO:0007155TASProcesscell adhesion
1501GO:0007158NASProcessneuron adhesion
1501GO:0007165TASProcesssignal transduction
1501GO:0007275IEAProcessdevelopment
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55914AAK69431.1densin-180-like proteinHPRD06090
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-2017NP_005222.2cortactin isoform aHPRD01268
-3932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
-23037NP_835260.1PDZ domain containing 3 isoform aHPRD10142
NP_001323.1--S-SCAMHPRD09181
NP_001323.155914-ErbinHPRD09181
NP_001323.12017-CortactinHPRD09181
NP_001323.12534-FynHPRD09181
NP_001323.13932-LckHPRD09181
NP_001323.15663NP_000012.1presenilin 1BIND55041
NP_001323.15664NP_000438.1presenilin 2 isoform 1HPRD02860
NP_001323.15664NP_000438.1presenilin 2 isoform 1HPRD09181
NP_001323.157554NP_065845.1leucine rich repeat containing 7HPRD09930
NP_001323.157554NP_065845.1leucine rich repeat containing 7HPRD09181
NP_001323.123037NP_835260.1PDZ domain containing 3 isoform aBIND130943
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1501CTND2_HUMANQ9UQB3IPR000225ArmadilloArmadillo
1501CTND2_HUMANQ9UQB3IPR000694PRO_richProline-rich region

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