Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:153
Official Symbol:ADRB1
Other Aliases:ADRB1R|B1AR|BETA1AR|RHR
See related:HGNC:285|MIM:109630|HPRD:00181
Chromosome:10
Location:10q24-q26
Gene Description:adrenergic, beta-1-, receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0259
ORGANISM:human
Entrez Gene ID:153
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
KARG Evidence 2
KARG ID:QTL0259
Trait:Chronic ethanol withdrawal
Peak:51
Peak Marker:D19Mit70
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
153GO:0001584IEAFunctionrhodopsin-like receptor activity
153GO:0004872IEAFunctionreceptor activity
153GO:0004935IEAFunctionadrenoceptor activity
153GO:0004940IEAFunctionbeta1-adrenergic receptor activity
153GO:0004940TASFunctionbeta1-adrenergic receptor activity
153GO:0005886TASComponentplasma membrane
153GO:0005887TASComponentintegral to plasma membrane
153GO:0007165IEAProcesssignal transduction
153GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
153GO:0007190TASProcessadenylate cyclase activation
153GO:0016020IEAComponentmembrane
153GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000675.1114928NP_001004051.1G protein-coupled receptor associated sorting protein 2BIND178818
NP_000675.11742NP_001356.1postsynaptic density protein 95HPRD04199
NP_000675.11742NP_001356.1postsynaptic density protein 95HPRD00181
NP_000675.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND130426
NP_000675.16456NP_003017.1SH3-domain GRB2-like 2BIND200025
NP_000675.16457NP_003018.2SH3-domain GRB2-like 3BIND200024
NP_000675.1408NP_004032.2arrestin beta 1 isoform AHPRD00181
NP_000675.1408NP_004032.2arrestin beta 1 isoform AHPRD00146
NP_000675.110755NP_005707.1regulator of G-protein signalling 19 interacting protein 1 isoform 1BIND55617
NP_000675.19863NP_036433.2membrane associated guanylate kinase, WW and PDZ domain containing 2HPRD16212
NP_000675.19737NP_055525.1G protein-coupled receptor associated sorting protein 1BIND178774
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
153ADRB1_HUMANP08588IPR0022325HT6_rcpt5-Hydroxytryptamine 6 receptor
153ADRB1_HUMANP08588IPR000507Adrgc_rcpt_B1Adrenergic receptor, beta 1
153ADRB1_HUMANP08588IPR002233Adrnrgc_rcptAdrenergic receptor
153ADRB1_HUMANP08588IPR000929Dopamine_rcptDopamine receptor
153ADRB1_HUMANP08588IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
153ADRB1_HUMANP08588IPR003980H3_rcptHistamine H3 receptor
153ADRB1_HUMANP08588IPR000694PRO_richProline-rich region

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