Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1535
Official Symbol:CYBA
Other Aliases:-
See related:HGNC:2577|MIM:608508|HPRD:01989
Chromosome:16
Location:16q24
Gene Description:cytochrome b-245, alpha polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0275
ORGANISM:human
Entrez Gene ID:1535
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-1.40
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13057CBCerebellum2.116328716278082.09641814231873
13057CTXCerebral cortex5.17030286788941.85338020324707
13057HIPHippocampal region1.591785192489621.498046875
13057HPFHippocampal formation2.431935548782351.73378348350525
13057HYHypothalamus0.3073689043521880.226377218961716
13057LSXLateral septal complex0.5158936381340030.340761244297028
13057MBMidbrain0.8249016404151920.779558956623077
13057MYMedulla1.743211507797241.54846811294556
13057OLFOlfactory bulb5.637564182281493.51258015632629
13057PPons0.9526086449623110.688859760761261
13057PALPallidum0.4872553646564480.236960202455521
13057RHPRetrohippocampal region3.726650238037112.01729249954224
13057sAMYStriatum-like amygdalar nuclei0.8567250370979310.809698224067688
13057STRStriatum0.6612703204154970.297693729400635
13057STRdStriatum dorsal region0.6224920749664310.240463063120842
13057STRvStriatum ventral region0.7584128975868230.262077569961548
13057THThalamus1.042107820510860.923048853874207
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1535GO:0005506IEAFunctioniron ion binding
1535GO:0005739NRComponentmitochondrion
1535GO:0006118IEAProcesselectron transport
1535GO:0006801NRProcesssuperoxide metabolism
1535GO:0016020IEAComponentmembrane
1535GO:0016491IEAFunctionoxidoreductase activity
1535GO:0020037IEAFunctionheme binding
1535GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4687NP_000256.1neutrophil cytosolic factor 1HPRD01990
-1536NP_000388.2cytochrome b-245, beta polypeptide (chronic granulomatous disease)HPRD02382
-4688NP_000424.1neutrophil cytosolic factor 2HPRD01991
-5879NP_061485.1ras-related C3 botulinum toxin substrate 1 isoform Rac1bHPRD03627
NP_000092.11536-Cytochrome b-245 beta polypeptideHPRD01989
NP_000092.14687-p47-phoxHPRD01989
NP_000092.14688-Neutrophil cytosolic factor 2HPRD01989
NP_000092.15879-Ras related C3 botulinum toxin substrate 1HPRD01989
NP_000092.127035--BIND185493
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1535CY24A_HUMANP13498IPR007732Cytochr_b558aCytochrome b558 alpha-subunit
1535CY24A_HUMANP13498IPR000694PRO_richProline-rich region

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