Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:154
Official Symbol:ADRB2
Other Aliases:ADRB2R|ADRBR|B2AR|BAR|BETA2AR
See related:HGNC:286|MIM:109690|HPRD:00187
Chromosome:5
Location:5q31-q32
Gene Description:adrenergic, beta-2-, receptor, surface
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0475
ORGANISM:human
Entrez Gene ID:154
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24176
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11555CBCerebellum7.165653228759777.19671583175659
11555CTXCerebral cortex7.618420600891115.03041648864746
11555HIPHippocampal region4.535019874572753.89484453201294
11555HPFHippocampal formation5.848643302917484.75966215133667
11555HYHypothalamus5.375745296478274.63093423843384
11555LSXLateral septal complex1.928501725196842.45729398727417
11555MBMidbrain5.175878524780275.00507831573486
11555MYMedulla10.187356948852510.1782245635986
11555OLFOlfactory bulb24.132099151611317.3111763000488
11555PPons11.202649116516112.7075796127319
11555PALPallidum4.711543083190923.59491014480591
11555RHPRetrohippocampal region8.36576938629156.12900018692017
11555sAMYStriatum-like amygdalar nuclei5.867259979248054.08666610717773
11555STRStriatum4.208331108093263.12279844284058
11555STRdStriatum dorsal region3.617757081985472.83806109428406
11555STRvStriatum ventral region6.179726600646973.68880939483643
11555THThalamus3.898890733718873.26177167892456
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
154GO:0000187TASProcessactivation of MAPK activity
154GO:0001584IEAFunctionrhodopsin-like receptor activity
154GO:0004872IEAFunctionreceptor activity
154GO:0004941TASFunctionbeta2-adrenergic receptor activity
154GO:0005515IPIFunctionprotein binding
154GO:0005764TASComponentlysosome
154GO:0005768TASComponentendosome
154GO:0005886TASComponentplasma membrane
154GO:0005887TASComponentintegral to plasma membrane
154GO:0006898TASProcessreceptor mediated endocytosis
154GO:0007171TASProcesstransmembrane receptor protein tyrosine kinase activation (dimerization)
154GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
154GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
154GO:0007190TASProcessadenylate cyclase activation
154GO:0007243TASProcessprotein kinase cascade
154GO:0008333TASProcessendosome to lysosome transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2767NP_002058.1guanine nucleotide binding protein (G protein), alpha 11 (Gq class)HPRD00759
-3763NP_002231.1potassium inwardly-rectifying channel J6HPRD02929
-407NP_004303.1arrestin 3, retinal (X-arrestin)HPRD02358
-9495NP_004848.2A-kinase anchor protein 5HPRD05255
-3765NP_004974.2potassium inwardly-rectifying channel subfamily J9HPRD02959
NP_000015.1--latent phosphatase 2HPRD00187
NP_000015.1---BIND215515
NP_000015.1---BIND215514
NP_000015.12767-Guanine nucleotide binding protein, alpha 11HPRD00187
NP_000015.19495-A kinase anchor protein 5HPRD00187
NP_000015.1407-Arrestin 3, retinalHPRD00187
NP_000015.13763-Potassium channel inwardly rectifying subfamily J, member 6HPRD00187
NP_000015.13765-GIRK3HPRD00187
NP_000015.19351AAC52090.1Homo sapiens Na+/H+ exchanger regulatory factor 2 (NHERF-2) mRNA, complete cds.BIND50097
NP_000015.14985NP_000902.2opioid receptor, delta 1HPRD01308
NP_000015.14985NP_000902.2opioid receptor, delta 1HPRD00187
NP_000015.11967NP_001405.1eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaHPRD09458
NP_000015.11967NP_001405.1eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaHPRD00187
NP_000015.11967NP_001405.1eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaBIND128133
NP_000015.12769NP_002059.1guanine nucleotide binding protein (G protein), alpha 15 (Gq class)HPRD00760
NP_000015.12769NP_002059.1guanine nucleotide binding protein (G protein), alpha 15 (Gq class)HPRD00187
NP_000015.12870NP_002073.1G protein-coupled receptor kinase 6HPRD00187
NP_000015.12870NP_002073.1G protein-coupled receptor kinase 6HPRD02925
NP_000015.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_000015.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00187
NP_000015.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
NP_000015.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD00187
NP_000015.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1BIND50011
NP_000015.19630NP_004288.1guanine nucleotide binding protein (G protein), alpha 14HPRD05095
NP_000015.19630NP_004288.1guanine nucleotide binding protein (G protein), alpha 14HPRD00187
NP_000015.19351NP_004776.1solute carrier family 9 isoform 3 regulator 2HPRD05946
NP_000015.19351NP_004776.1solute carrier family 9 isoform 3 regulator 2HPRD00187
NP_000015.19590NP_005091.2A-kinase anchor protein 12 isoform 1HPRD00187
NP_000015.19590NP_005091.2A-kinase anchor protein 12 isoform 1HPRD05263
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
154ADRB2_HUMANP07550IPR0015205HT4_rcpt5-Hydroxytryptamine 4 receptor
154ADRB2_HUMANP07550IPR000332Adrgc_rcpt_B2Adrenergic receptor, beta 2
154ADRB2_HUMANP07550IPR002233Adrnrgc_rcptAdrenergic receptor
154ADRB2_HUMANP07550IPR000929Dopamine_rcptDopamine receptor
154ADRB2_HUMANP07550IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
154ADRB2_HUMANP07550IPR001557L_LDH_MDHL-lactate/malate dehydrogenase
154ADRB2_HUMANP07550IPR000611NPY_rcptNeuropeptide Y receptor
154ADRB2_HUMANP07550IPR002002Octopmn_rcptOctopamine receptor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.