Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:156
Official Symbol:ADRBK1
Other Aliases:BARK1|BETA-ARK1|GRK2
See related:HGNC:289|MIM:109635|HPRD:00182
Chromosome:11
Location:11q13
Gene Description:adrenergic, beta, receptor kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0600
ORGANISM:human
Entrez Gene ID:156
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25238
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
110355CBCerebellum7.570102214813238.92274856567383
110355CTXCerebral cortex5.872136116027834.8644847869873
110355HIPHippocampal region10.323266029357910.3176717758179
110355HPFHippocampal formation10.48408508300789.5414457321167
110355HYHypothalamus2.642918586730961.99179196357727
110355LSXLateral septal complex0.04442795366048810.0
110355MBMidbrain4.672730445861824.35836315155029
110355MYMedulla12.445617675781212.6040687561035
110355OLFOlfactory bulb5.054381847381593.24711108207703
110355PPons7.543327331542978.10269641876221
110355PALPallidum2.898278713226322.71276807785034
110355RHPRetrohippocampal region10.88064384460458.67533397674561
110355sAMYStriatum-like amygdalar nuclei5.554031372070314.20323991775513
110355STRStriatum1.262115597724911.0432140827179
110355STRdStriatum dorsal region0.8136865496635440.756010711193085
110355STRvStriatum ventral region0.9241401553153990.698096811771393
110355THThalamus3.443165063858032.93731021881104
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
156GO:0000166IEAFunctionnucleotide binding
156GO:0004674IEAFunctionprotein serine/threonine kinase activity
156GO:0004703IEAFunctionG-protein coupled receptor kinase activity
156GO:0004871IEAFunctionsignal transducer activity
156GO:0004872IEAFunctionreceptor activity
156GO:0005524IEAFunctionATP binding
156GO:0005625TASComponentsoluble fraction
156GO:0005737TASComponentcytoplasm
156GO:0006468IEAProcessprotein amino acid phosphorylation
156GO:0007165TASProcesssignal transduction
156GO:0016740IEAFunctiontransferase activity
156GO:0047696IEAFunctionbeta-adrenergic receptor kinase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2492NP_000136.2follicle stimulating hormone receptor isoform 1 precursorHPRD00639
-6010NP_000530.1rhodopsinHPRD01584
-2776NP_002063.1guanine nucleotide binding protein (G protein), q polypeptideHPRD02998
-5132NP_002588.3phosducin isoform aHPRD01373
-408NP_004032.2arrestin beta 1 isoform AHPRD00146
-5082NP_005379.2phosducin-likeHPRD05108
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-1233NP_005499.1chemokine (C-C motif) receptor 4HPRD05324
-28964NP_054749.1G protein-coupled receptor kinase-interactor 1HPRD06577
-23413NP_055101.2frequenin homologHPRD04500
-9815NP_476510.1G protein-coupled receptor kinase-interactor 2 isoform 1HPRD09779
NP_001610.1--GIT2HPRD00182
NP_001610.1--PKCHPRD00182
NP_001610.1408-Beta arrestin 1HPRD00182
NP_001610.128964-GIT1HPRD00182
NP_001610.12492-Follicle stimulating hormone receptorHPRD00182
NP_001610.16010-RhodopsinHPRD00182
NP_001610.11233-CC chemokine receptor 4HPRD00182
NP_001610.15082-Phosducin likeHPRD00182
NP_001610.15132-PhosducinHPRD00182
NP_001610.123413-Neuronal calcium sensor 1HPRD00182
NP_001610.16714-c-SrcHPRD00182
NP_001610.12776-Guanine nucleotide binding protein G(q) alpha subunitHPRD00182
NP_001610.15037NP_002558.1prostatic binding proteinBIND54429
NP_001610.15579NP_002729.2protein kinase C, beta isoform 2HPRD00182
NP_001610.15957NP_002894.1recoverinHPRD01558
NP_001610.15957NP_002894.1recoverinHPRD00182
NP_001610.19590NP_005091.2A-kinase anchor protein 12 isoform 1HPRD00182
NP_001610.19590NP_005091.2A-kinase anchor protein 12 isoform 1HPRD05263
NP_001610.19815NP_476510.1G protein-coupled receptor kinase-interactor 2 isoform 1HPRD09779
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
156ARBK1_HUMANP25098IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
156ARBK1_HUMANP25098IPR000239GPCR_kinaseGPCR kinase
156ARBK1_HUMANP25098IPR001849PHPleckstrin-like
156ARBK1_HUMANP25098IPR000719Prot_kinaseProtein kinase
156ARBK1_HUMANP25098IPR000342RGSRegulator of G protein signalling
156ARBK1_HUMANP25098IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
156ARBK1_HUMANP25098IPR013695WAKWall-associated kinase

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