Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1565
Official Symbol:CYP2D6
Other Aliases:CPD6|CYP2D|CYP2D@|CYP2DL1|MGC120389|MGC120390|P450-DB1|P450C2D
See related:HGNC:2625|MIM:124030|HPRD:00487
Chromosome:22
Location:22q13.1
Gene Description:cytochrome P450, family 2, subfamily D, polypeptide 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0046
ORGANISM:human
Entrez Gene ID:1565
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10739167
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
68444CBCerebellum4.768111228942876.33478260040283
68444CTXCerebral cortex1.76043188571931.64814293384552
68444HIPHippocampal region4.139068126678473.84970569610596
68444HPFHippocampal formation3.738257646560673.69168543815613
68444HYHypothalamus4.658676147460946.48434400558472
68444LSXLateral septal complex0.1423143744468690.267612099647522
68444MBMidbrain1.191355466842652.98426675796509
68444MYMedulla4.72575139999397.50747966766357
68444OLFOlfactory bulb5.106943130493165.54477214813232
68444PPons5.8557376861572315.0346345901489
68444PALPallidum0.3294021487236020.310001522302628
68444RHPRetrohippocampal region1.82510864734652.03114581108093
68444sAMYStriatum-like amygdalar nuclei1.923201918601992.20755362510681
68444STRStriatum1.779303431510931.77472579479218
68444STRdStriatum dorsal region0.5852038860321040.517084360122681
68444STRvStriatum ventral region5.926241874694825.43431091308594
68444THThalamus0.3369991183280940.284566670656204
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1565GO:0004497IEAFunctionmonooxygenase activity
1565GO:0005506IEAFunctioniron ion binding
1565GO:0005783IEAComponentendoplasmic reticulum
1565GO:0005792IEAComponentmicrosome
1565GO:0006118IEAProcesselectron transport
1565GO:0016020IEAComponentmembrane
1565GO:0016712IEAFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1565GO:0019825NRFunctionoxygen binding
1565GO:0020037IEAFunctionheme binding
1565GO:0046872IEAFunctionmetal ion binding
1565GO:0050381IEAFunctionunspecific monooxygenase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000097.2---BIND153443
NP_000097.2---BIND153446
NP_000097.2---BIND153447
NP_000097.2---BIND151849
NP_000097.2---BIND151850
NP_000097.2---BIND153450
NP_000097.2---BIND153449
NP_000097.2---BIND153445
NP_000097.2---BIND153444
NP_000097.2---BIND151847
NP_000097.2---BIND151846
NP_000097.2---BIND151848
NP_000097.2---BIND151845
NP_000097.2---BIND153448
NP_000097.2---BIND183796
NP_000097.2---BIND183743
NP_000097.2---BIND183433
NP_000097.2---BIND183435
NP_000097.2---BIND183438
NP_000097.2---BIND183437
NP_000097.2---BIND183434
NP_000097.2---BIND183432
NP_000097.2---BIND183436
NP_000097.2---BIND153619
NP_000097.2---BIND153618
NP_000097.2---BIND153616
NP_000097.2---BIND209369
NP_000097.2---BIND181931
NP_000097.2---BIND181935
NP_000097.2---BIND196680
NP_000097.2---BIND196679
NP_000097.2---BIND262275
NP_000097.2---BIND262270
NP_000097.2---BIND181853
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1565IPR002397BP450B-class P450
1565IPR001128Cytochrome_P450Cytochrome P450
1565IPR002401EP450IE-class P450, group I
1565IPR002403EP450IVE-class P450, group IV
1565CP2D6_HUMANP10635IPR002397BP450B-class P450
1565CP2D6_HUMANP10635IPR001128Cytochrome_P450Cytochrome P450
1565CP2D6_HUMANP10635IPR002401EP450IE-class P450, group I
1565CP2D6_HUMANP10635IPR002403EP450IVE-class P450, group IV
1565CP2D6_HUMANP10635IPR008069EP450_CYP2DE-class P450, CYP2D
1565CP2D6_HUMANP10635IPR008071EP450_CYP2JE-class P450, CYP2J

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