Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1595
Official Symbol:CYP51A1
Other Aliases:CP51|CYP51|CYPL1|LDM|P450-14DM|P450L1
See related:HGNC:2649|MIM:601637|HPRD:03381
Chromosome:7
Location:7q21.2-q21.3
Gene Description:cytochrome P450, family 51, subfamily A, polypeptide 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0133
ORGANISM:human
Entrez Gene ID:1595
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.74 :: 3.22 :: -0.63 :: -1.76 :: -0.30 :: -3.94 :: -2.47
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13121CBCerebellum25.218036651611324.6590933799744
13121CTXCerebral cortex68.680660247802741.8798427581787
13121HIPHippocampal region40.847679138183638.9170742034912
13121HPFHippocampal formation58.15551757812547.3476791381836
13121HYHypothalamus78.511850357055755.645170211792
13121LSXLateral septal complex32.41079235076918.2949647903442
13121MBMidbrain62.591199874877948.7804508209229
13121MYMedulla68.278934478759874.2260551452637
13121OLFOlfactory bulb81.402107238769555.1648960113525
13121PPons75.951946258544974.4656753540039
13121PALPallidum56.282949447631847.6396789550781
13121RHPRetrohippocampal region80.028282165527356.5755462646484
13121sAMYStriatum-like amygdalar nuclei83.384712219238354.0488662719727
13121STRStriatum31.884962081909221.6134700775146
13121STRdStriatum dorsal region22.579413414001516.5314612388611
13121STRvStriatum ventral region31.514372825622619.6901369094849
13121THThalamus72.106500625610451.7673358917236
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1595GO:0004497IEAFunctionmonooxygenase activity
1595GO:0005506IEAFunctioniron ion binding
1595GO:0006118IEAProcesselectron transport
1595GO:0006695IEAProcesscholesterol biosynthesis
1595GO:0008398IEAFunctionsterol 14-demethylase activity
1595GO:0016020IEAComponentmembrane
1595GO:0016021IEAComponentintegral to membrane
1595GO:0020037IEAFunctionheme binding
1595GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1595CP51A_HUMANQ16850IPR002397BP450B-class P450
1595CP51A_HUMANQ16850IPR001128Cytochrome_P450Cytochrome P450
1595CP51A_HUMANQ16850IPR002401EP450IE-class P450, group I
1595CP51A_HUMANQ16850IPR002403EP450IVE-class P450, group IV
1595CP51A_HUMANQ16850IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap

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