Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:161
Official Symbol:AP2A2
Other Aliases:ADTAB|CLAPA2|HIP9|HYPJ
See related:HGNC:562|MIM:607242|HPRD:06256
Chromosome:11
Location:11p15.5
Gene Description:adaptor-related protein complex 2, alpha 2 subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0417
ORGANISM:human
Entrez Gene ID:161
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81637
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11772CBCerebellum61.5715503692627100.0
11772CTXCerebral cortex100.0100.0
11772HIPHippocampal region100.0100.0
11772HPFHippocampal formation100.0100.0
11772HYHypothalamus100.0100.0
11772LSXLateral septal complex100.0100.0
11772MBMidbrain100.0100.0
11772MYMedulla83.3619346618652100.0
11772OLFOlfactory bulb100.0100.0
11772PPons82.7257690429688100.0
11772PALPallidum93.708553314209100.0
11772RHPRetrohippocampal region100.0100.0
11772sAMYStriatum-like amygdalar nuclei100.0100.0
11772STRStriatum100.0100.0
11772STRdStriatum dorsal region100.0100.0
11772STRvStriatum ventral region100.0100.0
11772THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
161GO:0005198IEAFunctionstructural molecule activity
161GO:0005488IEAFunctionbinding
161GO:0005554NDFunctionmolecular function unknown
161GO:0005795IEAComponentGolgi stack
161GO:0005905IEAComponentcoated pit
161GO:0006461IEAProcessprotein complex assembly
161GO:0006886NASProcessintracellular protein transport
161GO:0006897IEAProcessendocytosis
161GO:0008289IEAFunctionlipid binding
161GO:0015031IEAProcessprotein transport
161GO:0030122NASComponentAP-2 adaptor complex
161GO:0030130IEAComponentclathrin coat of trans-Golgi network vesicle
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9829NP_055602.1DnaJ (Hsp40) homolog, subfamily C, member 6HPRD16326
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_036437.1--Eps15HPRD06256
NP_036437.1--p34HPRD06256
NP_036437.16464-SHCHPRD06256
NP_036437.1163AAH06201.1AP2B1 proteinHPRD06256
NP_036437.1163AAH06201.1AP2B1 proteinHPRD03015
NP_036437.11174NP_001274.1adaptor-related protein complex 1, sigma 1 subunit isoform 1HPRD04635
NP_036437.12060NP_001972.1epidermal growth factor receptor pathway substrate 15HPRD08968
NP_036437.12060NP_001972.1epidermal growth factor receptor pathway substrate 15HPRD06256
NP_036437.11759NP_004399.1dynamin 1HPRD03851
NP_036437.110928NP_006779.1ralA binding protein 1BIND185447
NP_036437.1274NP_647593.1bridging integrator 1 isoform 1HPRD03150
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
161AP2A2_HUMANO94973IPR008152A/G_adapt_CAlpha/gamma adaptin, C-terminal
161AP2A2_HUMANO94973IPR002553Adaptin_NAdaptin, N-terminal
161AP2A2_HUMANO94973IPR003164AP2_A_adaptin_CAP2 clathrin adaptin, alpha chain, C-terminal

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