Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1621
Official Symbol:DBH
Other Aliases:DBM
See related:HGNC:2689|MIM:609312|HPRD:01963
Chromosome:9
Location:9q34
Gene Description:dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0202
ORGANISM:human
Entrez Gene ID:1621
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
KARG Evidence 2
KARG ID:EVID0027
ORGANISM:human
Entrez Gene ID:1621
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:609312
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13166CBCerebellum4.921246081590654.79490527510643
13166CTXCerebral cortex4.809154331684113.70367911458015
13166HIPHippocampal region1.043322905898090.902617171406746
13166HPFHippocampal formation0.9997845888137820.796373546123505
13166HYHypothalamus0.5150269120931630.402798995375633
13166LSXLateral septal complex0.3807460218667980.89368611574173
13166MBMidbrain0.5218656510114670.612110182642937
13166MYMedulla5.283452749252327.38413095474243
13166OLFOlfactory bulb11.1506053656346.4365995824337
13166PPons4.824654221534738.34201049804688
13166PALPallidum5.695056661963464.11398988962173
13166RHPRetrohippocampal region0.9612450674176220.665312170982361
13166sAMYStriatum-like amygdalar nuclei7.784445289522415.25043691322207
13166STRStriatum6.971379145979884.5928081870079
13166STRdStriatum dorsal region9.312500238418586.15509536862373
13166STRvStriatum ventral region4.449239328503612.54601062834263
13166THThalamus1.565856054425241.2428879737854
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1621GO:0004497IEAFunctionmonooxygenase activity
1621GO:0004500IEAFunctiondopamine beta-monooxygenase activity
1621GO:0005507IEAFunctioncopper ion binding
1621GO:0005576NASComponentextracellular region
1621GO:0005624TASComponentmembrane fraction
1621GO:0005625TASComponentsoluble fraction
1621GO:0005737TASComponentcytoplasm
1621GO:0006548IEAProcesshistidine catabolism
1621GO:0007268TASProcesssynaptic transmission
1621GO:0016020IEAComponentmembrane
1621GO:0031418IEAFunctionL-ascorbic acid binding
1621GO:0042423IEAProcesscatecholamine biosynthesis
1621GO:0042583NASComponentchromaffin granule
1621GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000778.21621NP_000778.2dopamine beta-hydroxylase precursorHPRD01963
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1621DOPO_HUMANP09172IPR000323Cu2_ascorb_mOaseCopper type II, ascorbate-dependent monooxygenase
1621DOPO_HUMANP09172IPR013050DOMONDOMON
1621DOPO_HUMANP09172IPR005018DOMON_relDOMON related
1621DOPO_HUMANP09172IPR000945Dopamine_b_mOaseDopamine-beta-monooxygenase

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