Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1647
Official Symbol:GADD45A
Other Aliases:DDIT1|GADD45
See related:HGNC:4095|MIM:126335|HPRD:00528
Chromosome:1
Location:1p31.2-p31.1
Gene Description:growth arrest and DNA-damage-inducible, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0183
ORGANISM:human
Entrez Gene ID:1647
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13197
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13197CBCerebellum89.9124755859375100.0
13197CTXCerebral cortex100.0100.0
13197HIPHippocampal region100.0100.0
13197HPFHippocampal formation100.0100.0
13197HYHypothalamus57.054466247558664.9227523803711
13197LSXLateral septal complex64.855659484863361.3173789978027
13197MBMidbrain75.3511657714844100.0
13197MYMedulla74.1384429931641100.0
13197OLFOlfactory bulb97.1001052856445100.0
13197PPons63.490348815918100.0
13197PALPallidum57.610797882080171.5534973144531
13197RHPRetrohippocampal region100.0100.0
13197sAMYStriatum-like amygdalar nuclei54.812808990478554.1011810302734
13197STRStriatum76.836875915527376.7309265136719
13197STRdStriatum dorsal region82.912872314453184.6940231323242
13197STRvStriatum ventral region75.189704895019571.7656402587891
13197THThalamus56.455917358398470.5153656005859
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1647GO:0000079TASProcessregulation of cyclin dependent protein kinase activity
1647GO:0005634TASComponentnucleus
1647GO:0006281TASProcessDNA repair
1647GO:0006915TASProcessapoptosis
1647GO:0007049IEAProcesscell cycle
1647GO:0007050TASProcesscell cycle arrest
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-90480NP_443082.2growth arrest and DNA-damage-inducible, gamma interacting protein 1HPRD05519
AY135686.11958NP_001955.1early growth response 1BIND197320
NP_001915.1--HistoneHPRD00528
NP_001915.1--GADD45aHPRD00528
NP_001915.190480-PRG6HPRD00528
NP_001915.15465NP_001001930.1peroxisome proliferative activated receptor, alpha isoform 1HPRD00528
NP_001915.14869NP_002511.1nucleophosmin 1 isoform 1HPRD01246
NP_001915.15111NP_002583.1proliferating cell nuclear antigenHPRD00528
NP_001915.15111NP_002583.1proliferating cell nuclear antigenBIND295974
NP_001915.15111NP_002583.1proliferating cell nuclear antigenBIND295560
NP_001915.15111NP_002583.1proliferating cell nuclear antigenBIND153387
NP_001915.15111NP_002583.1proliferating cell nuclear antigenBIND209420
NP_001915.16256NP_002948.1retinoid X receptor, alphaHPRD01577
NP_001915.16256NP_002948.1retinoid X receptor, alphaHPRD00528
NP_001915.14216NP_005913.1mitogen-activated protein kinase kinase kinase 4 isoform aHPRD00528
NP_001915.14216NP_005913.1mitogen-activated protein kinase kinase kinase 4 isoform aHPRD03886
NP_001915.110912NP_006696.1growth arrest and DNA-damage-inducible, gammaHPRD00528
NP_001915.110912NP_006696.1growth arrest and DNA-damage-inducible, gammaHPRD05383
NP_001915.14616NP_056490.1growth arrest and DNA-damage-inducible, betaHPRD00528
NP_001915.14616NP_056490.1growth arrest and DNA-damage-inducible, betaHPRD05382
NP_001915.190480NP_443082.2growth arrest and DNA-damage-inducible, gamma interacting protein 1BIND130586
NP_001915.1121504NP_778224.1histone H4HPRD13662
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1647GA45A_HUMANP24522IPR004038Ribosomal_L7ARibosomal protein L7Ae/L30e/S12e/Gadd45

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