Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1738
Official Symbol:DLD
Other Aliases:DLDH|E3|GCSL|LAD|PHE3
See related:HGNC:2898|MIM:238331|HPRD:02006
Chromosome:7
Location:7q31-q32
Gene Description:dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0381
ORGANISM:human
Entrez Gene ID:1738
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:298942
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13382CBCerebellum37.818088531494193.9933624267578
13382CTXCerebral cortex100.0100.0
13382HIPHippocampal region66.0417327880859100.0
13382HPFHippocampal formation75.7702102661133100.0
13382HYHypothalamus52.724269866943448.1690101623535
13382LSXLateral septal complex61.122993469238348.6348762512207
13382MBMidbrain74.719863891601684.6305923461914
13382MYMedulla82.4899291992188100.0
13382OLFOlfactory bulb92.851348876953196.1819686889648
13382PPons65.717247009277392.279182434082
13382PALPallidum59.977535247802770.2093734741211
13382RHPRetrohippocampal region90.830589294433695.9657974243164
13382sAMYStriatum-like amygdalar nuclei53.884941101074244.3178787231445
13382STRStriatum60.968639373779348.5112419128418
13382STRdStriatum dorsal region58.965896606445347.3160209655762
13382STRvStriatum ventral region73.50965118408255.5522651672363
13382THThalamus83.468612670898493.2213363647461
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1738GO:0004148TASFunctiondihydrolipoyl dehydrogenase activity
1738GO:0005739TASComponentmitochondrion
1738GO:0006118IEAProcesselectron transport
1738GO:0015036IEAFunctiondisulfide oxidoreductase activity
1738GO:0050660IEAFunctionFAD binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000099.14967NP_002532.2oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) isoform 1 precursorHPRD02006
NP_000099.14967NP_002532.2oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) isoform 1 precursorHPRD08938
NP_000099.110295NP_005872.1branched chain ketoacid dehydrogenase kinaseHPRD12523
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1738DLDH_HUMANP09622IPR013027FAD_pyr_redoxFAD-dependent pyridine nucleotide-disulphide oxidoreductase
1738DLDH_HUMANP09622IPR002218GIDAGlucose-inhibited division protein A
1738DLDH_HUMANP09622IPR000815Hg_reductaseMercuric reductase
1738DLDH_HUMANP09622IPR000103Pyridine_redox_2Pyridine nucleotide-disulphide oxidoreductase, class-II
1738DLDH_HUMANP09622IPR001100Pyr_redoxPyridine nucleotide-disulphide oxidoreductase, class I
1738DLDH_HUMANP09622IPR001327Pyr_redox_NAD_bdPyridine nucleotide-disulphide oxidoreductase, NAD-binding region
1738DLDH_HUMANP09622IPR004099Pyr_redox_dimPyridine nucleotide-disulphide oxidoreductase dimerisation region
1738DLDH_HUMANP09622IPR012999Pyr_redox_I_ASPyridine nucleotide-disulphide oxidoreductase, class I, active site

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