Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1740
Official Symbol:DLG2
Other Aliases:DKFZp781D1854|DKFZp781E0954|FLJ37266|MGC131811|PSD-93
See related:HGNC:2901|MIM:603583|HPRD:04663
Chromosome:11
Location:11q14.1
Gene Description:discs, large homolog 2, chapsyn-110 (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0467
ORGANISM:human
Entrez Gene ID:1740
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64053
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
23859CBCerebellum23.04965686798163.9219646453857
23859CTXCerebral cortex100.0100.0
23859HIPHippocampal region90.8535194396973100.0
23859HPFHippocampal formation97.4607887268066100.0
23859HYHypothalamus22.234611511230515.9506363868713
23859LSXLateral septal complex100.0100.0
23859MBMidbrain20.33417415618916.8207750320435
23859MYMedulla23.058699607849123.1475162506104
23859OLFOlfactory bulb100.0100.0
23859PPons12.633314609527612.3014574050903
23859PALPallidum44.501800537109437.3328056335449
23859RHPRetrohippocampal region100.097.4812889099121
23859sAMYStriatum-like amygdalar nuclei86.842784881591862.0602779388428
23859STRStriatum100.086.0443000793457
23859STRdStriatum dorsal region100.084.1646003723145
23859STRvStriatum ventral region100.096.6774482727051
23859THThalamus8.843917846679699.12003898620605
KARG Evidence 2
KARG ID:HOT0113
Entrez Gene ID:1740
RefSeq ID:NM_001364
Position Information:-, Enhancer, 38096bp
Linkage Marker:D11S1354
Evidence Type:LINKAGE-BASED (SINGLE POINT)
Evidence Name:PUBMED
Evidence ID:14679582
Addiction Drug:TOBACCO
Addiction Drug Detail:HABITUAL SMOKING ABUSE
KARG Evidence 3
KARG ID:HOT0119
Entrez Gene ID:1740
RefSeq ID:NM_001364
Position Information:-, Enhancer, 38096bp
Linkage Marker:D11S1354
Evidence Type:LINKAGE-BASED (SINGLE POINT)
Evidence Name:PUBMED
Evidence ID:14679582
Addiction Drug:TOBACCO / ALCOHOL
Addiction Drug Detail:COMORBID HABITUAL SMOKING AND ALCOHOL ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1740GO:0003676IEAFunctionnucleic acid binding
1740GO:0004385TASFunctionguanylate kinase activity
1740GO:0004522IEAFunctionpancreatic ribonuclease activity
1740GO:0005515IPIFunctionprotein binding
1740GO:0005886TASComponentplasma membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4842NP_000611.1nitric oxide synthase 1 (neuronal)HPRD01226
-2903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorHPRD00698
-2904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD00697
-2977NP_000846.1guanylate cyclase 1, soluble, alpha 2HPRD03146
-1742NP_001356.1postsynaptic density protein 95HPRD04199
-4130NP_002364.3microtubule-associated protein 1AHPRD02549
-8825NP_004655.1lin-7 homolog AHPRD04542
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
-9419NP_054890.1postsynaptic protein CRIPTHPRD05208
-54413NP_061850.2neuroligin 3HPRD02275
-3768NP_066292.2potassium inwardly-rectifying channel J12HPRD09083
NP_001355.1--NR1HPRD04663
NP_001355.1--Kir2.3HPRD04663
NP_001355.14842-Nitric oxide synthase 1HPRD04663
NP_001355.11742-Synapse associated protein 90HPRD04663
NP_001355.154413-Neuroligin 3HPRD04663
NP_001355.19419-CRIPTHPRD04663
NP_001355.18825-Veli 1HPRD04663
NP_001355.14130-MAP1AHPRD04663
NP_001355.12904-N-methyl D-aspartate receptor subunit 2BHPRD04663
NP_001355.12903-N-methyl D-aspartate receptor subunit 2AHPRD04663
NP_001355.12977-Guanylate cyclase 1 soluble alpha 2HPRD04663
NP_001355.13739-Potassium channel, voltage gated, shaker related subfamily, member 4HPRD04663
NP_001355.14036NP_004516.1low density lipoprotein-related protein 2HPRD02509
NP_001355.14036NP_004516.1low density lipoprotein-related protein 2HPRD04663
NP_001355.19229NP_004737.2discs large homolog-associated protein 1 isoform alphaBIND296531
NP_001355.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD02767
NP_001355.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD04663
NP_001355.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4BIND149761
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1740DLG2_HUMANQ15700IPR008144Guanylate_kinGuanylate kinase
1740DLG2_HUMANQ15700IPR001478PDZPDZ/DHR/GLGF
1740DLG2_HUMANQ15700IPR000215Prot_inh_serpinProteinase inhibitor I4, serpin
1740DLG2_HUMANQ15700IPR001452SH3Src homology-3
1740DLG2_HUMANQ15700IPR011511SH3_2Variant SH3

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