Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1742
Official Symbol:DLG4
Other Aliases:PSD95|SAP90
See related:HGNC:2903|MIM:602887|HPRD:04199
Chromosome:17
Location:17p13.1
Gene Description:discs, large homolog 4 (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0323
ORGANISM:human
Entrez Gene ID:1742
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13385
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13385CBCerebellum100.0100.0
13385CTXCerebral cortex100.0100.0
13385HIPHippocampal region100.0100.0
13385HPFHippocampal formation100.0100.0
13385HYHypothalamus100.0100.0
13385LSXLateral septal complex100.0100.0
13385MBMidbrain100.0100.0
13385MYMedulla66.1050338745117100.0
13385OLFOlfactory bulb100.0100.0
13385PPons71.2482757568359100.0
13385PALPallidum100.0100.0
13385RHPRetrohippocampal region100.0100.0
13385sAMYStriatum-like amygdalar nuclei100.0100.0
13385STRStriatum100.0100.0
13385STRdStriatum dorsal region100.0100.0
13385STRvStriatum ventral region100.0100.0
13385THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1742GO:0005515IEAFunctionprotein binding
1742GO:0006461TASProcessprotein complex assembly
1742GO:0007165TASProcesssignal transduction
1742GO:0007268TASProcesssynaptic transmission
1742GO:0007399TASProcessnervous system development
1742GO:0007612TASProcesslearning
1742GO:0008022IPIFunctionprotein C-terminus binding
1742GO:0030863IDAComponentcortical cytoskeleton
1742GO:0045211IDAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55914AAK69431.1densin-180-like proteinHPRD06090
-27158AAL77754.1NADPH-dependent FMN- and FAD-containing oxidoreductaseHPRD10444
-4842NP_000611.1nitric oxide synthase 1 (neuronal)HPRD01226
-2897NP_000821.1glutamate receptor, ionotropic, kainate 1 isoform 1 precursorHPRD00693
-2906NP_000827.1N-methyl-D-aspartate receptor subunit 2D precursorHPRD04095
-2977NP_000846.1guanylate cyclase 1, soluble, alpha 2HPRD03146
-3358NP_000859.15-hydroxytryptamine (serotonin) receptor 2CHPRD02429
-3759NP_000882.1potassium inwardly-rectifying channel J2HPRD02815
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-2901NP_002079.3glutamate receptor KA2 precursorHPRD02614
-3766NP_002232.2potassium inwardly-rectifying channel, subfamily J, member 10HPRD03732
-4035NP_002323.1low density lipoprotein-related protein 1HPRD00138
-4130NP_002364.3microtubule-associated protein 1AHPRD02549
-4294NP_002437.2mitogen-activated protein kinase kinase kinase 10HPRD02533
-8321NP_003496.1frizzled 1HPRD04558
-8655NP_003737.1dynein light chain 1HPRD03334
-2185NP_004094.3PTK2B protein tyrosine kinase 2 beta isoform aHPRD03131
-10505NP_004254.2semaphorin WHPRD04748
-9615NP_004284.1guanine deaminaseHPRD08849
-2064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD01281
-8825NP_004655.1lin-7 homolog AHPRD04542
-9146NP_004703.1hepatocyte growth factor-regulated tyrosine kinase substrateHPRD05085
-9495NP_004848.2A-kinase anchor protein 5HPRD05255
-7525NP_005424.1viral oncogene yes-1 homolog 1HPRD01285
-10369NP_006069.1voltage-dependent calcium channel gamma-2 subunitHPRD04220
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
-8322NP_036325.2frizzled 4HPRD05203
-22941NP_036441.1SH3 and multiple ankyrin repeat domains 2 isoform 1HPRD04479
-9419NP_054890.1postsynaptic protein CRIPTHPRD05208
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-23095NP_055889.1kinesin family member 1BHPRD05818
-26037NP_056371.1signal-induced proliferation-associated 1 like 1HPRD11559
-50944NP_057232.1SH3 and multiple ankyrin repeat domains 1HPRD05413
-54910NP_060259.3semaphorin 4CHPRD07257
-54413NP_061850.2neuroligin 3HPRD02275
-57502NP_065793.1X-linked neuroligin 4HPRD02336
-57596NP_065887.1likely ortholog of rat brain-enriched guanylate kinase-associated proteinHPRD06459
-3768NP_066292.2potassium inwardly-rectifying channel J12HPRD09083
-2898NP_068775.1glutamate receptor 6 isoform 1 precursorHPRD00692
-140735NP_542408.1dynein light chain 2HPRD06489
NP_001356.1--NR1HPRD04199
NP_001356.1--NR3AHPRD04199
NP_001356.1--NR3BHPRD04199
NP_001356.1--NR4HPRD04199
NP_001356.1--Kv1.1HPRD04199
NP_001356.1--Kv1.3HPRD04199
NP_001356.1--GKAPHPRD04199
NP_001356.1--SAPAP1HPRD04199
NP_001356.1--SAPAP2HPRD04199
NP_001356.1--SAPAP3HPRD04199
NP_001356.1--SAPAP4HPRD04199
NP_001356.1--Neuroglin 1HPRD04199
NP_001356.1--Neuroglin 2HPRD04199
NP_001356.1--SynGAPHPRD04199
NP_001356.1--BEGAIN1HPRD04199
NP_001356.1--BEGAIN2HPRD04199
NP_001356.1--CitronHPRD04199
NP_001356.1--MAGUIN 1HPRD04199
NP_001356.1--Kir2.3HPRD04199
NP_001356.1--SPARHPRD04199
NP_001356.1--Kv1.5HPRD04199
NP_001356.1--Kv4.2HPRD04199
NP_001356.1--TamalinHPRD04199
NP_001356.12906-NMDAR2DHPRD04199
NP_001356.14842-Nitric oxide synthase 1HPRD04199
NP_001356.13737-Potassium voltage gated channel subfamily A member 2HPRD04199
NP_001356.13739-Potassium channel, voltage gated, shaker related subfamily, member 4HPRD04199
NP_001356.13766-Glial inwardly rectifying potassium channel Kir4.1HPRD04199
NP_001356.154413-Neuroligin 3HPRD04199
NP_001356.19419-CRIPTHPRD04199
NP_001356.157596-Brain enriched guanylate kinase associated proteinHPRD04199
NP_001356.14130-MAP1AHPRD04199
NP_001356.12898-Glutamate receptor, ionotropic kainate 2HPRD04199
NP_001356.12901-GRIK5HPRD04199
NP_001356.17525-c-YesHPRD04199
NP_001356.18825-Veli 1HPRD04199
NP_001356.150944-SH3 and multiple ankyrin repeat domains 1HPRD04199
NP_001356.15793-Protein tyrosine phosphatase, receptor-type, gammaHPRD04199
NP_001356.122941-SH3 and multiple ankyrin repeat domains 2HPRD04199
NP_001356.13759-Potassium channel, inwardly rectifying, subfamily J, member 2HPRD04199
NP_001356.14035-Low density lipoprotein receptor-related protein 1HPRD04199
NP_001356.12064-ERBB2HPRD04199
NP_001356.1140735-Dynein light chain 2HPRD04199
NP_001356.19495-A kinase anchor protein 5HPRD04199
NP_001356.154910-Semaphorin 4CHPRD04199
NP_001356.14294-MAP3K10HPRD04199
NP_001356.155914-ErbinHPRD04199
NP_001356.157502-Neuroligin 4HPRD04199
NP_001356.110505-SEMAWHPRD04199
NP_001356.12977-Guanylate cyclase 1 soluble alpha 2HPRD04199
NP_001356.110369-Calcium channel, voltage dependent, gamma subunit 2HPRD04199
NP_001356.15578-Protein kinase C alphaHPRD04199
NP_001356.13358-5-hydroxytryptamine receptor 2CHPRD04199
NP_001356.18321-Frizzled 1HPRD04199
NP_001356.18322-Frizzled 4HPRD04199
NP_001356.123095-KIF1BHPRD04199
NP_001356.19146-HrsHPRD04199
NP_001356.12534-FynHPRD04199
NP_001356.12185-Focal adhesion kinase 2HPRD04199
NP_001356.12897-Glutamate receptor, ionotropic kainate 1HPRD04199
NP_001356.18655-DLC1HPRD04199
NP_001356.155227AAK69623.1Homo sapiens leucine-rich repeats protein mRNA, complete cds.HPRD06430
NP_001356.155227AAK69623.1Homo sapiens leucine-rich repeats protein mRNA, complete cds.HPRD04199
NP_001356.13356NP_000612.15-hydroxytryptamine (serotonin) receptor 2AHPRD04199
NP_001356.13356NP_000612.15-hydroxytryptamine (serotonin) receptor 2AHPRD01638
NP_001356.12903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorHPRD04199
NP_001356.12903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorHPRD00698
NP_001356.12904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD00697
NP_001356.12904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD04199
NP_001356.12905NP_000826.1N-methyl-D-aspartate receptor subunit 2C precursorHPRD04199
NP_001356.12905NP_000826.1N-methyl-D-aspartate receptor subunit 2C precursorHPRD00699
NP_001356.13064NP_002102.2huntingtinBIND130458
NP_001356.14067NP_002341.1v-yes-1 Yamaguchi sarcoma viral related oncogene homologHPRD04199
NP_001356.14067NP_002341.1v-yes-1 Yamaguchi sarcoma viral related oncogene homologHPRD01301
NP_001356.14179NP_002380.3CD46 antigen, complement regulatory protein isoform 1 precursorHPRD04199
NP_001356.14179NP_002380.3CD46 antigen, complement regulatory protein isoform 1 precursorHPRD00406
NP_001356.18573NP_003679.1calcium/calmodulin-dependent serine protein kinase (MAGUK family)HPRD04199
NP_001356.18573NP_003679.1calcium/calmodulin-dependent serine protein kinase (MAGUK family)HPRD02164
NP_001356.14036NP_004516.1low density lipoprotein-related protein 2HPRD04199
NP_001356.14036NP_004516.1low density lipoprotein-related protein 2HPRD02509
NP_001356.19228NP_004736.2discs large-associated protein 2HPRD04199
NP_001356.19228NP_004736.2discs large-associated protein 2HPRD09258
NP_001356.19229NP_004737.2discs large homolog-associated protein 1 isoform alphaHPRD04199
NP_001356.19229NP_004737.2discs large homolog-associated protein 1 isoform alphaBIND54871
NP_001356.19311NP_004760.1amiloride-sensitive cation channel 3 isoform aBIND182658
NP_001356.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD04199
NP_001356.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD02767
NP_001356.12066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4BIND149759
NP_001356.123303NP_056069.1kinesin family member 13BHPRD09556
NP_001356.123390NP_056151.1huntingtin interacting protein 14BIND195708
NP_001356.19311NP_064717.1amiloride-sensitive cation channel 3 isoform bHPRD10626
NP_001356.185461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD18146
NT_010718.15---BIND183177
NT_010718.153084--BIND183173
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1742IPR008144Guanylate_kinGuanylate kinase
1742IPR001478PDZPDZ/DHR/GLGF
1742IPR002114PTS_HPr_SerP_SPhosphotransferase system, HPr serine phosphorylation site
1742IPR001452SH3Src homology-3
1742IPR011511SH3_2Variant SH3

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