Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1776
Official Symbol:DNASE1L3
Other Aliases:DHP2|DNAS1L3|LSD
See related:HGNC:2959|MIM:602244|HPRD:03764
Chromosome:3
Location:3p21.1-3p14.3
Gene Description:deoxyribonuclease I-like 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0548
ORGANISM:human
Entrez Gene ID:1776
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:116687
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13421CBCerebellum0.8418256044387822.03213858604431
13421CTXCerebral cortex0.5267311930656430.788335978984833
13421HIPHippocampal region0.7922232151031490.919512093067169
13421HPFHippocampal formation0.7238201498985290.760786771774292
13421HYHypothalamus0.2746160626411440.411060035228729
13421LSXLateral septal complex0.1446282565593720.560152053833008
13421MBMidbrain0.4226967096328740.751317024230957
13421MYMedulla0.2293406426906590.634612262248993
13421OLFOlfactory bulb0.8280608654022222.25517320632935
13421PPons0.647137165069580.958054661750793
13421PALPallidum0.4539799094200130.277667433023453
13421RHPRetrohippocampal region0.4174026250839230.430389314889908
13421sAMYStriatum-like amygdalar nuclei1.479132533073430.970671594142914
13421STRStriatum0.7956342697143550.647197067737579
13421STRdStriatum dorsal region0.8037130832672120.554541289806366
13421STRvStriatum ventral region0.7832981944084170.747992873191833
13421THThalamus0.445292651653290.426785677671432
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1776GO:0003677TASFunctionDNA binding
1776GO:0004519IEAFunctionendonuclease activity
1776GO:0004536TASFunctiondeoxyribonuclease activity
1776GO:0005509TASFunctioncalcium ion binding
1776GO:0005634IEAComponentnucleus
1776GO:0006308IEAProcessDNA catabolism
1776GO:0006915IEAProcessapoptosis
1776GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1776DNSL3_HUMANQ13609IPR008185DNase_IDeoxyribonuclease I
1776DNSL3_HUMANQ13609IPR005135Exo_endo_phosEndonuclease/exonuclease/phosphatase

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