Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1780
Official Symbol:DYNC1I1
Other Aliases:DNCI1|DNCIC1
See related:HGNC:2963|MIM:603772|HPRD:04798
Chromosome:7
Location:7q21.3-q22.1
Gene Description:dynein, cytoplasmic 1, intermediate chain 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0110
ORGANISM:human
Entrez Gene ID:1780
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:0.93 :: 1.37 :: 2.13 :: 2.12 :: -1.33 :: -0.21 :: 0.05
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13426CBCerebellum33.749580383300883.1596450805664
13426CTXCerebral cortex100.0100.0
13426HIPHippocampal region61.4787979125977100.0
13426HPFHippocampal formation81.7672348022461100.0
13426HYHypothalamus75.053520202636774.579833984375
13426LSXLateral septal complex46.389186859130936.0201187133789
13426MBMidbrain77.670867919921989.2345428466797
13426MYMedulla81.0678558349609100.0
13426OLFOlfactory bulb100.0100.0
13426PPons76.1738891601562100.0
13426PALPallidum75.518348693847785.9687576293945
13426RHPRetrohippocampal region100.0100.0
13426sAMYStriatum-like amygdalar nuclei70.305236816406262.0967292785645
13426STRStriatum36.045265197753930.205509185791
13426STRdStriatum dorsal region26.399839401245122.5128917694092
13426STRvStriatum ventral region45.897567749023434.9594841003418
13426THThalamus83.653495788574286.4783706665039
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1780GO:0003774TASFunctionmotor activity
1780GO:0005868TASComponentcytoplasmic dynein complex
1780GO:0005874IEAComponentmicrotubule
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6993NP_006510.1t-complex-associated-testis-expressed 1-like 1HPRD15987
NP_004402.16993NP_006510.1t-complex-associated-testis-expressed 1-like 1BIND315454
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1780DC1I1_HUMANO14576IPR013577LLGL2Lethal giant larvae homologue 2
1780DC1I1_HUMANO14576IPR000533TropomyosinTropomyosin
1780DC1I1_HUMANO14576IPR001680WD40WD-40 repeat

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