Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:18
Official Symbol:ABAT
Other Aliases:GABA-AT|GABAT|NPD009
See related:HGNC:23|MIM:137150|HPRD:00661
Chromosome:16
Location:16p13.2
Gene Description:4-aminobutyrate aminotransferase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0494
ORGANISM:human
Entrez Gene ID:18
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81632
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0289
ORGANISM:human
Entrez Gene ID:18
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:1471756
Addiction Drug:ALCOHOL
Addiction Drug Detail:The activity of GABA-T was found to be lower in alcoholics than in healthy volunteers
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
268860CBCerebellum56.7981300354004100.0
268860CTXCerebral cortex69.248970031738371.4790058135986
268860HIPHippocampal region42.995014190673871.334400177002
268860HPFHippocampal formation58.589235305786180.6584777832031
268860HYHypothalamus100.0100.0
268860LSXLateral septal complex92.56071853637791.479923248291
268860MBMidbrain96.9264030456543100.0
268860MYMedulla98.1758728027344100.0
268860OLFOlfactory bulb85.3694076538086100.0
268860PPons87.1389923095703100.0
268860PALPallidum91.9422912597656100.0
268860RHPRetrohippocampal region82.751209259033287.9089164733887
268860sAMYStriatum-like amygdalar nuclei100.0100.0
268860STRStriatum95.182819366455193.8800277709961
268860STRdStriatum dorsal region97.466583251953196.0072708129883
268860STRvStriatum ventral region83.547618865966881.6561336517334
268860THThalamus81.65446853637787.9579582214355
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
18GO:0003867NASFunction4-aminobutyrate transaminase activity
18GO:0005739IEAComponentmitochondrion
18GO:0005759NASComponentmitochondrial matrix
18GO:0007268NASProcesssynaptic transmission
18GO:0009448IEAProcessgamma-aminobutyric acid metabolism
18GO:0016740IEAFunctiontransferase activity
18GO:0030170IEAFunctionpyridoxal phosphate binding
18GO:0042135IEAProcessneurotransmitter catabolism
18GO:0047298IEAFunction(S)-3-amino-2-methylpropionate transaminase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000654.17915NP_733936.1aldehyde dehydrogenase 5A1 precursor, isoform 1HPRD00661
NP_000654.17915NP_733936.1aldehyde dehydrogenase 5A1 precursor, isoform 1HPRD08361
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
18GABT_HUMANP80404IPR005814Aminotrans_3Aminotransferase class-III

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