Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1808
Official Symbol:DPYSL2
Other Aliases:CRMP2|DHPRP2|DRP-2|DRP2
See related:HGNC:3014|MIM:602463|HPRD:03914
Chromosome:8
Location:8p22-p21
Gene Description:dihydropyrimidinase-like 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0253
ORGANISM:human
Entrez Gene ID:1808
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Downregulated
Fold Change:-1.1::-1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12934CBCerebellum53.7833786010742100.0
12934CTXCerebral cortex100.0100.0
12934HIPHippocampal region100.0100.0
12934HPFHippocampal formation100.0100.0
12934HYHypothalamus100.0100.0
12934LSXLateral septal complex100.0100.0
12934MBMidbrain100.0100.0
12934MYMedulla100.0100.0
12934OLFOlfactory bulb100.0100.0
12934PPons100.0100.0
12934PALPallidum100.0100.0
12934RHPRetrohippocampal region100.0100.0
12934sAMYStriatum-like amygdalar nuclei100.0100.0
12934STRStriatum95.8969192504883100.0
12934STRdStriatum dorsal region89.190856933593896.3579483032227
12934STRvStriatum ventral region100.0100.0
12934THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1808GO:0004157TASFunctiondihydropyrimidinase activity
1808GO:0006139TASProcessnucleobase, nucleoside, nucleotide and nucleic acid metabolism
1808GO:0007165TASProcesssignal transduction
1808GO:0007399TASProcessnervous system development
1808GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8650AAD54279.1Homo sapiens NUMB isoform 1 (NUMB) mRNA, complete cds.HPRD04767
-56896NP_064519.2dihydropyrimidinase-like 5HPRD10522
NP_001377.1--Tubulin-alphaHPRD03914
NP_001377.1--Tubulin-betaHPRD03914
NP_001377.1--ROK alphaHPRD03914
NP_001377.18650-NUMBHPRD03914
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1808DPYL2_HUMANQ16555IPR006680Amidohydro_1Amidohydrolase 1
1808DPYL2_HUMANQ16555IPR013108Amidohydro_3Amidohydrolase 3

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