Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1812
Official Symbol:DRD1
Other Aliases:DADR|DRD1A
See related:HGNC:3020|MIM:126449|HPRD:00538
Chromosome:5
Location:5q35.1
Gene Description:dopamine receptor D1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0453
ORGANISM:human
Entrez Gene ID:1812
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24316
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13488CBCerebellum9.4210662047068311.196341196696
13488CTXCerebral cortex14.09131940205899.40227913856506
13488HIPHippocampal region3.190396408242.86432985464732
13488HPFHippocampal formation8.510809501012177.08053513367971
13488HYHypothalamus4.387005597352982.22280438741048
13488LSXLateral septal complex21.50338339805617.0669011274974
13488MBMidbrain7.106193780899055.20717565218608
13488MYMedulla4.62058909734093.59748148918152
13488OLFOlfactory bulb13.70515513420111.1461527347565
13488PPons6.165984233220424.10799602667491
13488PALPallidum15.034293492635117.623851776123
13488RHPRetrohippocampal region17.152702728907312.4837634563446
13488sAMYStriatum-like amygdalar nuclei24.297972122828218.3744144439697
13488STRStriatum98.363151550293100.0
13488STRdStriatum dorsal region100.0100.0
13488STRvStriatum ventral region100.0100.0
13488THThalamus3.740076661109922.6555187702179
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1812GO:0001584IEAFunctionrhodopsin-like receptor activity
1812GO:0004872IEAFunctionreceptor activity
1812GO:0004952TASFunctiondopamine receptor activity
1812GO:0005886TASComponentplasma membrane
1812GO:0005887TASComponentintegral to plasma membrane
1812GO:0007165IEAProcesssignal transduction
1812GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
1812GO:0007191TASProcessdopamine receptor, adenylate cyclase activating pathway
1812GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1812GO:0007268TASProcesssynaptic transmission
1812GO:0007399NRProcessnervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
-50632NP_056537.1dopamine receptor D1 interacting proteinHPRD06871
NP_000785.150632-CalcyonHPRD00538
NP_000785.12037NP_001422.1erythrocyte membrane protein band 4.1-like 2HPRD09126
NP_000785.126958NP_036265.1coatomer protein complex, subunit gamma 2HPRD00538
NP_000785.126958NP_036265.1coatomer protein complex, subunit gamma 2HPRD05074
NP_000785.122820NP_057212.1coatomer protein complex, subunit gamma 1HPRD00538
NP_000785.122820NP_057212.1coatomer protein complex, subunit gamma 1HPRD09887
NP_000785.185406NP_115740.4dopamine receptor interacting proteinHPRD12082
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1812DRD1_HUMANP21728IPR0022325HT6_rcpt5-Hydroxytryptamine 6 receptor
1812DRD1_HUMANP21728IPR002233Adrnrgc_rcptAdrenergic receptor
1812DRD1_HUMANP21728IPR001413Dopa1A_rcptDopamine 1A receptor
1812DRD1_HUMANP21728IPR000929Dopamine_rcptDopamine receptor
1812DRD1_HUMANP21728IPR000497Dopa_1B_rcptDopamine 1B receptor
1812DRD1_HUMANP21728IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1812DRD1_HUMANP21728IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.