Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1813
Official Symbol:DRD2
Other Aliases:D2DR|D2R
See related:HGNC:3023|MIM:126450|HPRD:00539
Chromosome:11
Location:11q23
Gene Description:dopamine receptor D2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0007
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:1832466
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0010
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:8033754
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0014
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:8807661
Addiction Drug:GAMBLING
Addiction Drug Detail:PATHOLOGICAL GAMBLING
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0015
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:8874837
Addiction Drug:STRESS
Addiction Drug Detail:POSTTRAUMATIC STRESS DISORDER
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVIL0021
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9498485
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:EVIL0104
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14643564
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:EVIL0106
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14732864
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 8
KARG ID:EVIL0117
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15184239
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 9
KARG ID:EVIL0123
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15270299
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIATE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 10
KARG ID:EVIL0129
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15381926
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 11
KARG ID:EVIL0135
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15492764
Addiction Drug:BUPROPION
Addiction Drug Detail:BUPROPION-BASED ADMINISTRATION
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 12
KARG ID:EVIL0151
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15704216
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIATE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 13
KARG ID:EVIL0166
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15955630
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 14
KARG ID:EVID0009
ORGANISM:human
Entrez Gene ID:1813
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:126450
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13489CBCerebellum2.432631254196172.53777265548706
13489CTXCerebral cortex1.463685274124151.59092634916306
13489HIPHippocampal region1.188113957643511.43641152977943
13489HPFHippocampal formation1.226507619023321.39647355675697
13489HYHypothalamus6.729995489120487.10854303836823
13489LSXLateral septal complex42.853771209716846.9950637817383
13489MBMidbrain11.94746446609518.5580229759216
13489MYMedulla7.676310062408458.75453531742096
13489OLFOlfactory bulb1.779172182083132.19855868816376
13489PPons3.906866490840914.88347160816193
13489PALPallidum16.995766639709522.2855825424194
13489RHPRetrohippocampal region1.247078254818921.39020478725433
13489sAMYStriatum-like amygdalar nuclei14.097651958465614.3558830022812
13489STRStriatum96.175910949707100.0
13489STRdStriatum dorsal region100.0100.0
13489STRvStriatum ventral region100.0100.0
13489THThalamus3.566966831684113.05294367671013
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1813GO:0001584IEAFunctionrhodopsin-like receptor activity
1813GO:0004952TASFunctiondopamine receptor activity
1813GO:0005882TASComponentintermediate filament
1813GO:0005886TASComponentplasma membrane
1813GO:0005887TASComponentintegral to plasma membrane
1813GO:0007165TASProcesssignal transduction
1813GO:0007195TASProcessdopamine receptor, adenylate cyclase inhibiting pathway
1813GO:0007268TASProcesssynaptic transmission
1813GO:0007399TASProcessnervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6755NP_001044.1somatostatin receptor 5HPRD01677
-2771NP_002061.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2HPRD00764
-2781NP_002064.1guanine nucleotide binding protein, alpha z polypeptideHPRD00746
-3763NP_002231.1potassium inwardly-rectifying channel J6HPRD02929
-3765NP_004974.2potassium inwardly-rectifying channel subfamily J9HPRD02959
-2773NP_006487.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3HPRD00765
-23413NP_055101.2frequenin homologHPRD04500
-84687NP_115984.1protein phosphatase 1, regulatory subunit 9BHPRD04506
-54102Q96NY7Chloride intracellular channel 6.HPRD10836
NP_000786.1---BIND149054
NP_000786.1---BIND146554
NP_000786.1---BIND149055
NP_000786.12781-Guanine nucleotide binding protein, alpha Z polypeptideHPRD00539
NP_000786.184687-PPP1R9BHPRD00539
NP_000786.184687-Protein phosphatase 1, regulatory subunit 9BHPRD00539
NP_000786.16755-Somatostatin receptor 5HPRD00539
NP_000786.12771-GNAI2HPRD00539
NP_000786.12773-Guanine nucleotide binding alpha inhibiting activity polypeptide 3HPRD00539
NP_000786.13763-Potassium channel inwardly rectifying subfamily J, member 6HPRD00539
NP_000786.13765-G protein activated inward rectifier potassium channel 3HPRD00539
NP_000786.13765-GIRK3HPRD00539
NP_000786.123413-Neuronal calcium sensor 1HPRD00539
NP_000786.154102-Chloride intracellular channel 6HPRD00539
NP_000786.12035AAD42222.1Homo sapiens protein 4.1 (EPB4.1) mRNA, complete cds.HPRD00539
NP_000786.12035AAD42222.1Homo sapiens protein 4.1 (EPB4.1) mRNA, complete cds.HPRD00558
NP_000786.12316NP_001447.1filamin 1 (actin-binding protein-280)BIND24475
NP_000786.12316NP_001447.1filamin 1 (actin-binding protein-280)HPRD02060
NP_000786.12316NP_001447.1filamin 1 (actin-binding protein-280)HPRD00539
NP_000786.12036NP_036288.2erythrocyte membrane protein band 4.1-like 1 isoform aHPRD04193
NP_000786.12036NP_036288.2erythrocyte membrane protein band 4.1-like 1 isoform aHPRD00539
NP_000786.123413NP_055101.2frequenin homologBIND19090
NP_057658.2---BIND149210
NP_057658.2---BIND149211
NP_057658.22316NP_001447.1filamin 1 (actin-binding protein-280)BIND24476
NP_057658.21813NP_057658.2dopamine receptor D2 isoform shortBIND149209
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1813IPR0022315HT_rcpt5-Hydroxytryptamine receptor
1813IPR002233Adrnrgc_rcptAdrenergic receptor
1813IPR000929Dopamine_rcptDopamine receptor
1813IPR001922Dopa_D2_rcptDopamine D2 receptor
1813IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1813IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
1813IPR000995Musac_rcptMuscarinic acetylcholine receptor
1813IPR000611NPY_rcptNeuropeptide Y receptor
1813DRD2_HUMANP14416IPR002233Adrnrgc_rcptAdrenergic receptor
1813DRD2_HUMANP14416IPR000929Dopamine_rcptDopamine receptor
1813DRD2_HUMANP14416IPR001922Dopa_D2_rcptDopamine D2 receptor
1813DRD2_HUMANP14416IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1813DRD2_HUMANP14416IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
1813DRD2_HUMANP14416IPR000995Musac_rcptMuscarinic acetylcholine receptor
1813DRD2_HUMANP14416IPR000611NPY_rcptNeuropeptide Y receptor

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