Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1814
Official Symbol:DRD3
Other Aliases:D3DR
See related:HGNC:3024|MIM:126451|HPRD:00540
Chromosome:3
Location:3q13.3
Gene Description:dopamine receptor D3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0160
ORGANISM:human
Entrez Gene ID:1814
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13490
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0585
ORGANISM:human
Entrez Gene ID:1814
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29238
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13490CBCerebellum4.789735615253455.45817071199417
13490CTXCerebral cortex4.261409342288972.97749426960945
13490HIPHippocampal region2.095051422715191.77862544357777
13490HPFHippocampal formation2.936021059751512.3836512863636
13490HYHypothalamus3.289421662688262.25457866489887
13490LSXLateral septal complex12.9781961441049.42398834228516
13490MBMidbrain2.250325888395311.98497924208641
13490MYMedulla8.761483430862438.81288161873817
13490OLFOlfactory bulb11.26116663217548.7048332542181
13490PPons3.437909722328193.39671717584133
13490PALPallidum8.775214433670046.77053356170654
13490RHPRetrohippocampal region4.383834749460223.25383520126343
13490sAMYStriatum-like amygdalar nuclei3.334199666976932.09783190488815
13490STRStriatum8.838431596755986.05175971984863
13490STRdStriatum dorsal region3.040688306093222.07027243077755
13490STRvStriatum ventral region29.385927677154518.7138216495514
13490THThalamus5.484491586685183.89753367006779
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1814GO:0001584IEAFunctionrhodopsin-like receptor activity
1814GO:0004872IEAFunctionreceptor activity
1814GO:0004952IEAFunctiondopamine receptor activity
1814GO:0004952TASFunctiondopamine receptor activity
1814GO:0005886TASComponentplasma membrane
1814GO:0005887TASComponentintegral to plasma membrane
1814GO:0007165IEAProcesssignal transduction
1814GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
1814GO:0007212TASProcessdopamine receptor signaling pathway
1814GO:0007268NRProcesssynaptic transmission
1814GO:0007610TASProcessbehavior
1814GO:0016020IEAComponentmembrane
1814GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00756
-54102Q96NY7Chloride intracellular channel 6.HPRD10836
NP_000787.1--MPDZHPRD00540
NP_000787.12770-G protein, alpha inhibiting 1HPRD00540
NP_000787.154102-Chloride intracellular channel 6HPRD00540
NP_000787.18777-Multiple PDZ domain proteinHPRD00540
NP_000787.12035AAD42222.1Homo sapiens protein 4.1 (EPB4.1) mRNA, complete cds.HPRD00540
NP_000787.12035AAD42222.1Homo sapiens protein 4.1 (EPB4.1) mRNA, complete cds.HPRD00558
NP_000787.12037NP_001422.1erythrocyte membrane protein band 4.1-like 2HPRD09126
NP_000787.12316NP_001447.1filamin 1 (actin-binding protein-280)BIND24477
NP_000787.12316NP_001447.1filamin 1 (actin-binding protein-280)HPRD02060
NP_000787.12316NP_001447.1filamin 1 (actin-binding protein-280)HPRD00540
NP_000787.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND129609
NP_000787.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_000787.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00540
NP_000787.14690NP_006144.1NCK adaptor protein 1BIND129607
NP_000787.12036NP_036288.2erythrocyte membrane protein band 4.1-like 1 isoform aHPRD04193
NP_000787.12036NP_036288.2erythrocyte membrane protein band 4.1-like 1 isoform aHPRD00540
NP_000787.123413NP_055101.2frequenin homologBIND19089
NP_387512.12316NP_001447.1filamin 1 (actin-binding protein-280)BIND24844
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1814IPR0022315HT_rcpt5-Hydroxytryptamine receptor
1814IPR002233Adrnrgc_rcptAdrenergic receptor
1814IPR001620DopaD3_rcptDopamine D3 receptor
1814IPR000929Dopamine_rcptDopamine receptor
1814IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1814IPR000611NPY_rcptNeuropeptide Y receptor
1814DRD3_HUMANP35462IPR0022315HT_rcpt5-Hydroxytryptamine receptor
1814DRD3_HUMANP35462IPR002233Adrnrgc_rcptAdrenergic receptor
1814DRD3_HUMANP35462IPR001620DopaD3_rcptDopamine D3 receptor
1814DRD3_HUMANP35462IPR000929Dopamine_rcptDopamine receptor
1814DRD3_HUMANP35462IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1814DRD3_HUMANP35462IPR000611NPY_rcptNeuropeptide Y receptor

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