Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1815
Official Symbol:DRD4
Other Aliases:D4DR
See related:HGNC:3025|MIM:126452|HPRD:00541
Chromosome:11
Location:11p15.5
Gene Description:dopamine receptor D4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0011
ORGANISM:human
Entrez Gene ID:1815
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:8216280
Addiction Drug:ALCOHOL
Addiction Drug Detail:CHRONIC ALCOHOLICS
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0017
ORGANISM:human
Entrez Gene ID:1815
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9152990
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0036
ORGANISM:human
Entrez Gene ID:1815
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10402503
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0057
ORGANISM:human
Entrez Gene ID:1815
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:11324944
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:DRUG ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVIL0065
ORGANISM:human
Entrez Gene ID:1815
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:11950104
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13491CBCerebellum18.003974914550813.7369742393494
13491CTXCerebral cortex12.46988570690168.02530384063721
13491HIPHippocampal region11.68775069713595.98347955942154
13491HPFHippocampal formation15.413473129272510.2508619427681
13491HYHypothalamus14.93866848945628.4591726064682
13491LSXLateral septal complex5.288314558565622.44727234914899
13491MBMidbrain12.47458982467658.14558577537537
13491MYMedulla18.054507732391413.4010796546936
13491OLFOlfactory bulb29.658259868621817.9511700868607
13491PPons16.767450332641612.2287817001343
13491PALPallidum11.63316833972938.00543487071991
13491RHPRetrohippocampal region19.878507375717214.7143853902817
13491sAMYStriatum-like amygdalar nuclei14.49737191200268.37724149227142
13491STRStriatum6.568688154220583.66231465339661
13491STRdStriatum dorsal region2.369930624961851.44134506583214
13491STRvStriatum ventral region17.19827818870548.45068660378456
13491THThalamus5.603491067886353.04082208871841
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1815GO:0001584IEAFunctionrhodopsin-like receptor activity
1815GO:0004872IEAFunctionreceptor activity
1815GO:0004952IEAFunctiondopamine receptor activity
1815GO:0004952NASFunctiondopamine receptor activity
1815GO:0004952TASFunctiondopamine receptor activity
1815GO:0005886TASComponentplasma membrane
1815GO:0005887TASComponentintegral to plasma membrane
1815GO:0007165IEAProcesssignal transduction
1815GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
1815GO:0007212NASProcessdopamine receptor signaling pathway
1815GO:0007212TASProcessdopamine receptor signaling pathway
1815GO:0007268TASProcesssynaptic transmission
1815GO:0016020IEAComponentmembrane
1815GO:0016020NASComponentmembrane
1815GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2554NP_000797.1gamma-aminobutyric acid (GABA) A receptor, alpha 1 precursorHPRD00662
-3765NP_004974.2potassium inwardly-rectifying channel subfamily J9HPRD02959
-54102Q96NY7Chloride intracellular channel 6.HPRD10836
AAB59386.1---BIND130565
AAB59386.1---BIND130560
AAB59386.1---BIND130566
AAB59386.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND130430
AAB59386.14690NP_006144.1NCK adaptor protein 1BIND129606
DYHUD42885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND130429
DYHUD44690NP_006144.1NCK adaptor protein 1BIND129618
NP_000788.12554-GABA-A receptor, alpha 1HPRD00541
NP_000788.13765-GIRK3HPRD00541
NP_000788.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_000788.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00541
NP_000788.14690NP_006144.1NCK adaptor protein 1HPRD02740
NP_000788.14690NP_006144.1NCK adaptor protein 1HPRD00541
NP_000788.2---BIND130564
NP_000788.2---BIND130561
NP_000788.2---BIND130571
NP_000788.22885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND130428
NP_000788.26714NP_005408.1proto-oncogene tyrosine-protein kinase SRCBIND130431
NP_000788.24690NP_006144.1NCK adaptor protein 1BIND129617
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1815IPR0022315HT_rcpt5-Hydroxytryptamine receptor
1815IPR002185DopaD4_rcptDopamine D4 receptor
1815IPR000929Dopamine_rcptDopamine receptor
1815IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1815IPR000694PRO_richProline-rich region

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