Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1824
Official Symbol:DSC2
Other Aliases:CDHF2|DG2|DGII/III|DKFZp686I11137|DSC3
See related:HGNC:3036|MIM:125645|HPRD:00512
Chromosome:18
Location:18q12.1
Gene Description:desmocollin 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0893
ORGANISM:human
Entrez Gene ID:1824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-4.2 :: -2.9
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13506CBCerebellum0.4427177309989931.00960624217987
13506CTXCerebral cortex0.1601814925670620.284349173307419
13506HIPHippocampal region0.1914685964584350.318975448608398
13506HPFHippocampal formation0.2254128903150560.572402119636536
13506HYHypothalamus0.09463868290185930.0813785269856453
13506LSXLateral septal complex0.00.0
13506MBMidbrain0.1350980997085570.176775142550468
13506MYMedulla0.1811578124761580.223195254802704
13506OLFOlfactory bulb0.3493681550025941.16181099414825
13506PPons0.1945841163396840.209430113434792
13506PALPallidum0.09933326393365860.158846139907837
13506RHPRetrohippocampal region0.2981233596801760.962721407413483
13506sAMYStriatum-like amygdalar nuclei0.07462298870086670.0521014779806137
13506STRStriatum0.1162291914224620.228980377316475
13506STRdStriatum dorsal region0.1255599111318590.277727961540222
13506STRvStriatum ventral region0.1681588292121890.263058483600616
13506THThalamus0.1602259129285810.194009408354759
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1824GO:0005509IEAFunctioncalcium ion binding
1824GO:0005515IEAFunctionprotein binding
1824GO:0005856IEAComponentcytoskeleton
1824GO:0005911NRComponentintercellular junction
1824GO:0007155TASProcesscell adhesion
1824GO:0007156IEAProcesshomophilic cell adhesion
1824GO:0016020IEAComponentmembrane
1824GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_077740.11828NP_001933.1desmoglein 1 preproproteinHPRD00512
NP_077740.11828NP_001933.1desmoglein 1 preproproteinHPRD00515
NP_077740.11829NP_001934.1desmoglein 2 preproproteinHPRD00512
NP_077740.11829NP_001934.1desmoglein 2 preproproteinHPRD00516
NP_077740.13728NP_002221.1junction plakoglobinHPRD00512
NP_077740.15318NP_004563.1plakophilin 2 isoform 2bHPRD04177
NP_077740.15318NP_004563.1plakophilin 2 isoform 2bHPRD00512
NP_077740.111187NP_009114.1plakophilin 3HPRD05711
NP_077740.111187NP_009114.1plakophilin 3HPRD00512
NP_077740.111187NP_009114.1plakophilin 3BIND257835
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1824IPR002126CadherinCadherin
1824IPR009124DesmocollinDesmocollin
1824IPR013585ProtocadherinProtocadherin
1824DSC2_HUMANQ02487IPR002126CadherinCadherin
1824DSC2_HUMANQ02487IPR009124DesmocollinDesmocollin
1824DSC2_HUMANQ02487IPR009123DesmogleinDesmoglein
1824DSC2_HUMANQ02487IPR009122Desmo_cadherinDesmosomal cadherin
1824DSC2_HUMANQ02487IPR013585ProtocadherinProtocadherin

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