Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:183
Official Symbol:AGT
Other Aliases:ANHU|SERPINA8
See related:HGNC:333|MIM:106150|HPRD:00106
Chromosome:1
Location:1q42-q43
Gene Description:angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0977
ORGANISM:human
Entrez Gene ID:183
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11606CBCerebellum34.569028854370132.8655157089233
11606CTXCerebral cortex4.750815987586983.92340242862701
11606HIPHippocampal region11.300436496734611.530425786972
11606HPFHippocampal formation11.645862817764311.5041601657867
11606HYHypothalamus73.212692260742282.5511703491211
11606LSXLateral septal complex2.104930773377421.89746341109276
11606MBMidbrain43.949815750122143.5583763122559
11606MYMedulla36.310750961303733.6268396377563
11606OLFOlfactory bulb13.329778671264610.2328305244446
11606PPons39.656160354614337.6614656448364
11606PALPallidum25.405849456787124.1329040527344
11606RHPRetrohippocampal region11.897665739059410.8441960811615
11606sAMYStriatum-like amygdalar nuclei41.082792282104542.5311946868896
11606STRStriatum5.457792043685915.3190701007843
11606STRdStriatum dorsal region1.026880651712420.845542252063751
11606STRvStriatum ventral region2.867278695106511.75478368997574
11606THThalamus38.969919204711938.4817810058594
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
183GO:0004867TASFunctionserine-type endopeptidase inhibitor activity
183GO:0005179NRFunctionhormone activity
183GO:0005576NASComponentextracellular region
183GO:0005625TASComponentsoluble fraction
183GO:0007166TASProcesscell surface receptor linked signal transduction
183GO:0007267TASProcesscell-cell signaling
183GO:0007565TASProcesspregnancy
183GO:0008217TASProcessblood pressure regulation
183GO:0042310IEAProcessvasoconstriction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-186NP_000677.2angiotensin II receptor, type 2HPRD02071
-4142NP_002368.1MAS1 oncogeneHPRD01306
-4224NP_005579.1meprin A, alpha (PABA peptide hydrolase)HPRD02666
-23549NP_036232.1aspartyl aminopeptidaseHPRD09924
NP_000020.1--LDLHPRD00106
NP_000020.1--BradykininHPRD00106
NP_000020.14224-Meprin A alphaHPRD00106
NP_000020.1186-Angiotensin II receptor type 2HPRD00106
NP_000020.14142-Mas1HPRD00106
NP_000020.123549-Aspartyl aminopeptidaseHPRD00106
NP_000020.15553NP_002719.3proteoglycan 2 preproproteinHPRD00106
NP_000020.15553NP_002719.3proteoglycan 2 preproproteinHPRD09283
NP_000020.1185NP_114038.1angiotensin II receptor, type 1HPRD00106
NP_000020.1185NP_114038.1angiotensin II receptor, type 1HPRD00107
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
183ANGT_HUMANP01019IPR000227AngiotensngnAngiotensinogen
183ANGT_HUMANP01019IPR000434PKD_1Polycystic kidney disease type 1 protein
183ANGT_HUMANP01019IPR000215Prot_inh_serpinProteinase inhibitor I4, serpin

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