Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1846
Official Symbol:DUSP4
Other Aliases:HVH2|MKP-2|MKP2|TYP
See related:HGNC:3070|MIM:602747|HPRD:04123
Chromosome:8
Location:8p12-p11
Gene Description:dual specificity phosphatase 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0204
ORGANISM:human
Entrez Gene ID:1846
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
319520CBCerebellum8.646817684173589.84991335868835
319520CTXCerebral cortex12.58617019653329.57034707069397
319520HIPHippocampal region22.362489700317429.0741453170776
319520HPFHippocampal formation22.217896461486824.3323221206665
319520HYHypothalamus2.106141686439511.72736066579819
319520LSXLateral septal complex12.780807495117211.0846157073975
319520MBMidbrain2.998287320137023.07003843784332
319520MYMedulla8.009687900543219.44408798217773
319520OLFOlfactory bulb20.101157188415517.273898601532
319520PPons5.696541309356696.51767420768738
319520PALPallidum3.426798701286323.37203145027161
319520RHPRetrohippocampal region22.825033664703419.2313866615295
319520sAMYStriatum-like amygdalar nuclei4.244603395462043.26645481586456
319520STRStriatum2.887788414955142.40866184234619
319520STRdStriatum dorsal region1.305993586778641.07778680324554
319520STRvStriatum ventral region3.603527307510382.87956309318542
319520THThalamus5.631967544555664.58004093170166
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1846GO:0000074NASProcessregulation of progression through cell cycle
1846GO:0000165TASProcessMAPKKK cascade
1846GO:0004725IEAFunctionprotein tyrosine phosphatase activity
1846GO:0005634TASComponentnucleus
1846GO:0006470IEAProcessprotein amino acid dephosphorylation
1846GO:0006470TASProcessprotein amino acid dephosphorylation
1846GO:0008330TASFunctionprotein tyrosine/threonine phosphatase activity
1846GO:0016787IEAFunctionhydrolase activity
1846GO:0017017IEAFunctionMAP kinase phosphatase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5595NP_002737.1mitogen-activated protein kinase 3HPRD03479
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
NP_001385.15594-ERK2HPRD04123
NP_001385.15595-ERK1HPRD04123
NP_001385.12902-Glutamate receptor ionotropic, N-methyl D-aspartate 1HPRD04123
NP_001385.12906-NMDAR2DHPRD04123
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1846IPR000340DS_phosphataseDual specificity protein phosphatase
1846IPR008343MAPK_phosphMAP kinase phosphatase
1846IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase
1846DUS4_HUMANQ13115IPR000340DS_phosphataseDual specificity protein phosphatase
1846DUS4_HUMANQ13115IPR008343MAPK_phosphMAP kinase phosphatase
1846DUS4_HUMANQ13115IPR001763Rhodanese-likeRhodanese-like
1846DUS4_HUMANQ13115IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase

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