Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1848
Official Symbol:DUSP6
Other Aliases:MKP3|PYST1
See related:HGNC:3072|MIM:602748|HPRD:04124
Chromosome:12
Location:12q22-q23
Gene Description:dual specificity phosphatase 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0236
ORGANISM:human
Entrez Gene ID:1848
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:67603
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67603CBCerebellum4.206491827964785.08227205276489
67603CTXCerebral cortex73.113609313964860.7572021484375
67603HIPHippocampal region39.498558998107963.6462154388428
67603HPFHippocampal formation40.930941581726149.3873958587646
67603HYHypothalamus0.8609565980732440.508779760450125
67603LSXLateral septal complex9.677451416850095.07106727361679
67603MBMidbrain1.328183650970461.75963562726974
67603MYMedulla0.9183874726295471.0630242228508
67603OLFOlfactory bulb40.698499679565431.8945055007935
67603PPons0.364757448434830.613653942942619
67603PALPallidum2.206211552023891.25951865315437
67603RHPRetrohippocampal region42.390828132629433.2231311798096
67603sAMYStriatum-like amygdalar nuclei8.560157299041754.9879891872406
67603STRStriatum22.802019834518412.8106524944305
67603STRdStriatum dorsal region28.131964206695616.2155547142029
67603STRvStriatum ventral region19.00582706928259.83624404668808
67603THThalamus12.08056735992436.93242359161377
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1848GO:0000074NASProcessregulation of progression through cell cycle
1848GO:0000188IDAProcessinactivation of MAPK activity
1848GO:0004722IDAFunctionprotein serine/threonine phosphatase activity
1848GO:0004725IDAFunctionprotein tyrosine phosphatase activity
1848GO:0005625TASComponentsoluble fraction
1848GO:0005737IDAComponentcytoplasm
1848GO:0006470TASProcessprotein amino acid dephosphorylation
1848GO:0016787IEAFunctionhydrolase activity
1848GO:0017017IEAFunctionMAP kinase phosphatase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5595NP_002737.1mitogen-activated protein kinase 3HPRD03479
NP_001937.15594-ERK2HPRD04124
NP_001937.15594-ERK2HPRD04124
NP_001937.15595-ERK1HPRD04124
NP_001937.2---BIND218033
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1848IPR000340DS_phosphataseDual specificity protein phosphatase
1848IPR008343MAPK_phosphMAP kinase phosphatase
1848IPR001763Rhodanese-likeRhodanese-like
1848IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase
1848DUS6_HUMANQ16828IPR000340DS_phosphataseDual specificity protein phosphatase
1848DUS6_HUMANQ16828IPR008343MAPK_phosphMAP kinase phosphatase
1848DUS6_HUMANQ16828IPR001763Rhodanese-likeRhodanese-like
1848DUS6_HUMANQ16828IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase

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