Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1902
Official Symbol:EDG2
Other Aliases:Gpcr26|LPA1|LPAR1|Mrec1.3|edg-2|rec.1.3|vzg-1
See related:HGNC:3166|MIM:602282|HPRD:03790
Chromosome:9
Location:9q31.3
Gene Description:endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0111
ORGANISM:human
Entrez Gene ID:1902
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14745
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0083
ORGANISM:human
Entrez Gene ID:1902
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.34 :: 0.21 :: -0.44 :: -1.58 :: -0.84 :: -0.79 :: -0.56 :: 0.18 :: 0.43 :: -1.07
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14745CBCerebellum48.77323246002266.545396010081
14745CTXCerebral cortex70.378572781880768.6139286359151
14745HIPHippocampal region70.867351849873969.6379070281982
14745HPFHippocampal formation70.415265719095969.1966528892517
14745HYHypothalamus69.408529917399168.0151033401489
14745LSXLateral septal complex73.454825719197669.8039429982503
14745MBMidbrain71.212707201639869.447106997172
14745MYMedulla71.454896608988469.2248525619507
14745OLFOlfactory bulb72.702824910481870.3987019856771
14745PPons72.16369374593169.3219590187073
14745PALPallidum71.029184023539268.8223872184753
14745RHPRetrohippocampal region69.495593706766868.4285531044006
14745sAMYStriatum-like amygdalar nuclei69.888662338256868.2605330149333
14745STRStriatum71.321404457092368.902148882548
14745STRdStriatum dorsal region71.901076634724969.2648475964864
14745STRvStriatum ventral region69.203879356384367.8400520483653
14745THThalamus70.756965319315669.1231133143107
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1902GO:0001619IEAFunctionlysosphingolipid and lysophosphatidic acid receptor activity
1902GO:0004872IEAFunctionreceptor activity
1902GO:0005886TASComponentplasma membrane
1902GO:0005887TASComponentintegral to plasma membrane
1902GO:0007165IEAProcesssignal transduction
1902GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
1902GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
1902GO:0007202TASProcessphospholipase C activation
1902GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1902GO:0016020IEAComponentmembrane
1902GO:0016021IEAComponentintegral to membrane
1902GO:0043123IEPProcesspositive regulation of I-kappaB kinase/NF-kappaB cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2773NP_006487.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3HPRD00765
NP_476500.12773-Guanine nucleotide binding alpha inhibiting activity polypeptide 3HPRD03790
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1902EDG2_HUMANQ92633IPR002230Cnbnoid_rcptCannabinoid receptor
1902EDG2_HUMANQ92633IPR000987EDG1_rcptEDG-1 sphingosine 1-phosphate receptor
1902EDG2_HUMANQ92633IPR002277EDG2_rcptEDG-2 lysophosphatidic acid receptor
1902EDG2_HUMANQ92633IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1902EDG2_HUMANQ92633IPR004065LPA_rcptLysophosphatidic acid receptor
1902EDG2_HUMANQ92633IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor

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