Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1903
Official Symbol:EDG3
Other Aliases:EDG-3|FLJ37523|LPB3|MGC71696|S1P3|S1PR3
See related:HGNC:3167|MIM:601965|HPRD:03572
Chromosome:9
Location:9q22.1-q22.2
Gene Description:endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0919
ORGANISM:human
Entrez Gene ID:1903
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.7
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13610CBCerebellum7.842047214508069.16287899017334
13610CTXCerebral cortex11.15535259246837.36991739273071
13610HIPHippocampal region3.504254817962653.18966364860535
13610HPFHippocampal formation4.589589118957523.94522643089294
13610HYHypothalamus5.119671344757083.82498550415039
13610LSXLateral septal complex4.739563465118418.45058441162109
13610MBMidbrain10.71342563629158.85858726501465
13610MYMedulla32.622318267822332.4185066223145
13610OLFOlfactory bulb16.934337615966812.6696672439575
13610PPons15.844958305358915.5213842391968
13610PALPallidum10.4326925277718.31823921203613
13610RHPRetrohippocampal region6.516474246978765.04225063323975
13610sAMYStriatum-like amygdalar nuclei2.979318380355831.94336473941803
13610STRStriatum7.170086383819585.11852931976318
13610STRdStriatum dorsal region5.839125156402594.06380748748779
13610STRvStriatum ventral region19.306322097778311.9098539352417
13610THThalamus7.459219932556155.36521673202515
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1903GO:0001619IEAFunctionlysosphingolipid and lysophosphatidic acid receptor activity
1903GO:0004872IEAFunctionreceptor activity
1903GO:0005886TASComponentplasma membrane
1903GO:0005887TASComponentintegral to plasma membrane
1903GO:0006954TASProcessinflammatory response
1903GO:0007165IEAProcesssignal transduction
1903GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
1903GO:0007204TASProcesselevation of cytosolic calcium ion concentration
1903GO:0008284TASProcesspositive regulation of cell proliferation
1903GO:0008289TASFunctionlipid binding
1903GO:0009653TASProcessmorphogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3350NP_000515.15-hydroxytryptamine (serotonin) receptor 1AHPRD00190
-2770NP_002060.3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1HPRD00756
-2776NP_002063.1guanine nucleotide binding protein (G protein), q polypeptideHPRD02998
-10672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
NP_005217.110672-Guanine nucleotide binding protein, alpha 13HPRD03572
NP_005217.12770-G protein, alpha inhibiting 1HPRD03572
NP_005217.12776-Guanine nucleotide binding protein G(q) alpha subunitHPRD03572
NP_005217.13350-5-hydroxytryptamine receptor, 1AHPRD03572
NP_005217.23350NP_000515.25-hydroxytryptamine (serotonin) receptor 1ABIND216550
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1903EDG3_HUMANQ99500IPR000194ATPase_a_b_nl-bdATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
1903EDG3_HUMANQ99500IPR002230Cnbnoid_rcptCannabinoid receptor
1903EDG3_HUMANQ99500IPR000987EDG1_rcptEDG-1 sphingosine 1-phosphate receptor
1903EDG3_HUMANQ99500IPR004062EDG3_rcptEDG-3 sphingosine 1-phosphate receptor
1903EDG3_HUMANQ99500IPR000708EP1_rcptProstanoid EP1 receptor
1903EDG3_HUMANQ99500IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
1903EDG3_HUMANQ99500IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
1903EDG3_HUMANQ99500IPR004061S1P_rcptSphingosine 1-phosphate receptor

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