Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1949
Official Symbol:EFNB3
Other Aliases:EFL6|EPLG8|LERK8
See related:HGNC:3228|MIM:602297|HPRD:03804
Chromosome:17
Location:17p13.1-p11.2
Gene Description:ephrin-B3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0311
ORGANISM:human
Entrez Gene ID:1949
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13643
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13643CBCerebellum15.749895036220614.2009170055389
13643CTXCerebral cortex21.182506620883915.7537305355072
13643HIPHippocampal region44.808298110961954.1606736183167
13643HPFHippocampal formation44.443683624267650.6465504169464
13643HYHypothalamus35.831633090972927.0138945579529
13643LSXLateral septal complex50.165185868740150.1032702997327
13643MBMidbrain32.921917974948923.9655686020851
13643MYMedulla41.875398159027131.7504296302795
13643OLFOlfactory bulb38.655075073242232.8655827045441
13643PPons40.208562135696429.5069410800934
13643PALPallidum43.606975555419938.3793166875839
13643RHPRetrohippocampal region44.59313368797337.3583369255066
13643sAMYStriatum-like amygdalar nuclei42.376707077026434.0685834884644
13643STRStriatum45.500636935234134.1447086334229
13643STRdStriatum dorsal region43.807803869247432.5423648357391
13643STRvStriatum ventral region46.784924507141132.2619925737381
13643THThalamus22.785671368241315.8538871109486
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1949GO:0005005TASFunctiontransmembrane-ephrin receptor activity
1949GO:0005887TASComponentintegral to plasma membrane
1949GO:0007267TASProcesscell-cell signaling
1949GO:0007399TASProcessnervous system development
1949GO:0016020IEAComponentmembrane
1949GO:0030154IEAProcesscell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2043NP_004429.1ephrin receptor EphA4HPRD03719
-2049NP_004434.2ephrin receptor EphB3 precursorHPRD03502
NP_001397.1--GRIP2HPRD03804
NP_001397.12043-EphA4HPRD03804
NP_001397.12049-EphB3HPRD03804
NP_001397.154933NP_060291.1rhomboid-related protein 2HPRD07151
NP_001397.154933NP_060291.1rhomboid-related protein 2HPRD03804
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1949EFNB3_HUMANQ15768IPR001799EphrinEphrin
1949EFNB3_HUMANQ15768IPR003979tropoelastinTropoelastin

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