Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1956
Official Symbol:EGFR
Other Aliases:ERBB|ERBB1|mENA
See related:HGNC:3236|MIM:131550|HPRD:00579
Chromosome:7
Location:7p12
Gene Description:epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0206
ORGANISM:human
Entrez Gene ID:1956
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13649CBCerebellum62.476552963256858.290376663208
13649CTXCerebral cortex100.092.4678993225098
13649HIPHippocampal region91.067878723144584.1992645263672
13649HPFHippocampal formation99.054790496826289.908130645752
13649HYHypothalamus100.085.6977882385254
13649LSXLateral septal complex100.079.0658187866211
13649MBMidbrain81.800773620605564.8506259918213
13649MYMedulla87.453151702880982.1176834106445
13649OLFOlfactory bulb100.0100.0
13649PPons88.504028320312582.1406097412109
13649PALPallidum79.400730133056659.6453895568848
13649RHPRetrohippocampal region100.095.0565948486328
13649sAMYStriatum-like amygdalar nuclei98.734321594238367.1734504699707
13649STRStriatum71.051164627075247.1540069580078
13649STRdStriatum dorsal region50.502042770385734.1067934036255
13649STRvStriatum ventral region94.461208343505968.6113452911377
13649THThalamus48.511695861816435.5161123275757
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1956GO:0000166IEAFunctionnucleotide binding
1956GO:0001503NASProcessossification
1956GO:0003690NASFunctiondouble-stranded DNA binding
1956GO:0004710NASFunctionMAP/ERK kinase kinase activity
1956GO:0004888IDAFunctiontransmembrane receptor activity
1956GO:0005006IDAFunctionepidermal growth factor receptor activity
1956GO:0005006NASFunctionepidermal growth factor receptor activity
1956GO:0005515IPIFunctionprotein binding
1956GO:0005524IEAFunctionATP binding
1956GO:0005615NASComponentextracellular space
1956GO:0005634IDAComponentnucleus
1956GO:0005768IDAComponentendosome
1956GO:0005886IDAComponentplasma membrane
1956GO:0006468IEAProcessprotein amino acid phosphorylation
1956GO:0006950NASProcessresponse to stress
1956GO:0007049IEAProcesscell cycle
1956GO:0007166IDAProcesscell surface receptor linked signal transduction
1956GO:0007173IDAProcessepidermal growth factor receptor signaling pathway
1956GO:0007202TASProcessphospholipase C activation
1956GO:0008283TASProcesscell proliferation
1956GO:0016021IEAComponentintegral to membrane
1956GO:0016337IMPProcesscell-cell adhesion
1956GO:0016740IEAFunctiontransferase activity
1956GO:0030122TASComponentAP-2 adaptor complex
1956GO:0030235IDAFunctionnitric-oxide synthase regulator activity
1956GO:0030335IMPProcesspositive regulation of cell migration
1956GO:0042327IDAProcesspositive regulation of phosphorylation
1956GO:0043006TASProcesscalcium-dependent phospholipase A2 activation
1956GO:0043406IDAProcesspositive regulation of MAPK activity
1956GO:0045429IDAProcesspositive regulation of nitric oxide biosynthesis
1956GO:0045786IEAProcessnegative regulation of progression through cell cycle
1956GO:0046982IDAFunctionprotein heterodimerization activity
1956GO:0050679IDAProcesspositive regulation of epithelial cell proliferation
1956GO:0050730IMPProcessregulation of peptidyl-tyrosine phosphorylation
1956GO:0050999IDAProcessregulation of nitric-oxide synthase activity
1956GO:0051015IDAFunctionactin filament binding
1956GO:0051205TASProcessprotein insertion into membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
--X97821.1H.sapiens promotor of inducible nitric oxide synthase geneBIND300540
-2353K00650.1Human fos proto-oncogene (c-fos), and translated productsBIND300545
-2887NP_001001550.1growth factor receptor-bound protein 10 isoform cBIND183784
-2069NP_001423.1epiregulin precursorHPRD03638
-2547NP_001460.1ATP-dependent DNA helicase II, 70 kDa subunitHPRD01071
-3636NP_001558.2inositol polyphosphate phosphatase-like 1HPRD02900
-2549NP_002030.1GRB2-associated binding protein 1HPRD05116
-2771NP_002061.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2HPRD00764
-2885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND215881
-3371NP_002151.1tenascin C (hexabrachion)HPRD01756
-3678NP_002196.1integrin alpha 5 precursorHPRD00627
-5335NP_002651.2phospholipase C gamma 1 isoform aHPRD01398
-5338NP_002654.2phospholipase D2HPRD03857
-5777NP_002822.2protein tyrosine phosphatase, non-receptor type 6 isoform 1HPRD01475
-6464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND180620
-6642NP_003090.2sorting nexin 1 isoform aHPRD03171
-8440NP_003572.1NCK adaptor protein 2HPRD05378
-8560NP_003667.1degenerative spermatocyte homolog 1, lipid desaturaseHPRD13133
-8737NP_003795.1receptor (TNFRSF)-interacting serine-threonine kinase 1HPRD04583
-9020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD05230
-9046NP_003965.2docking protein 2HPRD05411
-2185NP_004094.3PTK2B protein tyrosine kinase 2 beta isoform aHPRD03131
-2059NP_004438.1epidermal growth factor receptor pathway substrate 8HPRD02563
-2886NP_005301.1growth factor receptor-bound protein 7HPRD03311
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-6654NP_005624.2son of sevenless homolog 1HPRD01681
-10188NP_005772.2activated p21cdc42Hs kinaseHPRD06104
-5753NP_005966.1PTK6 protein tyrosine kinase 6HPRD03594
-10451NP_006104.3vav 3 oncogeneHPRD05706
-5306NP_006215.1phosphatidylinositol transfer protein, alphaHPRD02548
-6655NP_008870.1son of sevenless homolog 2HPRD03149
-11184NP_009112.1mitogen-activated protein kinase kinase kinase kinase 1HPRD03583
-3084NP_039250.1neuregulin 1 isoform HRG-beta1HPRD00802
-7534NP_663723.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideBIND185503
NP_005219.1--F actinHPRD00579
NP_005219.1--EPS15HPRD00579
NP_005219.1--CBLCHPRD00579
NP_005219.1--Tenascin CHPRD00579
NP_005219.1--Mig-6HPRD00579
NP_005219.1--Mitogen inducible gene 6 proteinHPRD00579
NP_005219.1--PLSCR1HPRD00579
NP_005219.1--Histone H3HPRD00579
NP_005219.1--CoxIIHPRD00579
NP_005219.18440-Grb4HPRD00579
NP_005219.12059-EPS8HPRD00579
NP_005219.12059-Epidermal growth factor receptor kinase substrate EPS8HPRD00579
NP_005219.15770-PTPN1HPRD00579
NP_005219.12241-FERHPRD00579
NP_005219.15781-SHP2HPRD00579
NP_005219.15306-PITPNHPRD00579
NP_005219.110188-ACKHPRD00579
NP_005219.16642-Sorting nexin 1HPRD00579
NP_005219.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00579
NP_005219.13084-Neuregulin 1HPRD00579
NP_005219.15753-Protein tyrosine kinase 6HPRD00579
NP_005219.18560-Degenerative spermatocyte homolog 1 lipid desaturaseHPRD00579
NP_005219.15335-Phospholipase C, gamma 1HPRD00579
NP_005219.111184-HPK1HPRD00579
NP_005219.12069-EpiregulinHPRD00579
NP_005219.12547-Ku antigen, 70kDaHPRD00579
NP_005219.12547-Ku70HPRD00579
NP_005219.16654-SOS1HPRD00579
NP_005219.12886-Grb7HPRD00579
NP_005219.15777-SHP1HPRD00579
NP_005219.15338-Phospholipase D2HPRD00579
NP_005219.19046-DOK2HPRD00579
NP_005219.16655-SOS2HPRD00579
NP_005219.12185-Focal adhesion kinase 2HPRD00579
NP_005219.12185-PTK2B protein tyrosine kinase 2 betaHPRD00579
NP_005219.15747-FAKHPRD00579
NP_005219.13678-Integrin alpha 5HPRD00579
NP_005219.16714-c-SrcHPRD00579
NP_005219.110451-VAV3HPRD00579
NP_005219.18737-RIPHPRD00579
NP_005219.18737-Receptor interacting proteinHPRD00579
NP_005219.19020-NIKHPRD00579
NP_005219.12771-GNAI2HPRD00579
NP_005219.13636-Inositol polyphosphate phosphatase like 1HPRD00579
NP_005219.12549-GAB1HPRD00579
NP_005219.12099NP_000116.1estrogen receptor 1HPRD00589
NP_005219.12099NP_000116.1estrogen receptor 1HPRD00579
NP_005219.13875NP_000215.1keratin 18HPRD01020
NP_005219.13875NP_000215.1keratin 18HPRD00579
NP_005219.13872NP_000413.1keratin 17HPRD01019
NP_005219.13872NP_000413.1keratin 17HPRD00579
NP_005219.12060NP_001972.1epidermal growth factor receptor pathway substrate 15HPRD08968
NP_005219.12060NP_001972.1epidermal growth factor receptor pathway substrate 15HPRD00579
NP_005219.12065NP_001973.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 3HPRD00579
NP_005219.12065NP_001973.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 3HPRD01820
NP_005219.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_005219.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00579
NP_005219.13064NP_002102.2huntingtinHPRD00883
NP_005219.13064NP_002102.2huntingtinHPRD00579
NP_005219.13732NP_002222.1CD82 antigen isoform 1HPRD09004
NP_005219.13732NP_002222.1CD82 antigen isoform 1HPRD00579
NP_005219.13856NP_002264.1keratin 8HPRD01015
NP_005219.13856NP_002264.1keratin 8HPRD00579
NP_005219.15159NP_002600.1platelet-derived growth factor receptor beta precursorHPRD00579
NP_005219.15287NP_002637.2phosphoinositide-3-kinase, class 2, beta polypeptideHPRD00579
NP_005219.15287NP_002637.2phosphoinositide-3-kinase, class 2, beta polypeptideHPRD04160
NP_005219.15566NP_002721.1cAMP-dependent protein kinase catalytic subunit alpha isoform 1HPRD03382
NP_005219.15566NP_002721.1cAMP-dependent protein kinase catalytic subunit alpha isoform 1HPRD00579
NP_005219.15573NP_002725.1cAMP-dependent protein kinase, regulatory subunit alpha 1HPRD01786
NP_005219.15573NP_002725.1cAMP-dependent protein kinase, regulatory subunit alpha 1HPRD00579
NP_005219.15578NP_002728.1protein kinase C, alphaHPRD00579
NP_005219.15795NP_002834.2protein tyrosine phosphatase, receptor type, J precursorHPRD00579
NP_005219.15795NP_002834.2protein tyrosine phosphatase, receptor type, J precursorHPRD02955
NP_005219.15921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00579
NP_005219.15921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
NP_005219.16004NP_002919.2regulator of G-protein signalling 16HPRD00579
NP_005219.16004NP_002919.2regulator of G-protein signalling 16HPRD03945
NP_005219.16643NP_003091.2sorting nexin 2HPRD00579
NP_005219.16643NP_003091.2sorting nexin 2HPRD09332
NP_005219.16776NP_003143.2signal transducer and activator of transcription 5AHPRD03301
NP_005219.16776NP_003143.2signal transducer and activator of transcription 5AHPRD00579
NP_005219.17039NP_003227.1transforming growth factor, alphaHPRD07522
NP_005219.17039NP_003227.1transforming growth factor, alphaHPRD00579
NP_005219.17082NP_003248.2tight junction protein 1 isoform aHPRD03002
NP_005219.17082NP_003248.2tight junction protein 1 isoform aHPRD00579
NP_005219.17410NP_003362.1vav 2 oncogeneHPRD02694
NP_005219.17410NP_003362.1vav 2 oncogeneHPRD00579
NP_005219.18651NP_003736.1suppressor of cytokine signaling 1HPRD00579
NP_005219.18651NP_003736.1suppressor of cytokine signaling 1HPRD04669
NP_005219.18723NP_003785.1sorting nexin 4HPRD00579
NP_005219.18723NP_003785.1sorting nexin 4HPRD09334
NP_005219.18882NP_003895.1zinc finger protein 259HPRD00579
NP_005219.18882NP_003895.1zinc finger protein 259HPRD04877
NP_005219.19021NP_003946.2suppressor of cytokine signaling 3HPRD05006
NP_005219.19021NP_003946.2suppressor of cytokine signaling 3HPRD00579
NP_005219.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD01281
NP_005219.12064NP_004439.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologHPRD00579
NP_005219.12888NP_004481.1growth factor receptor-bound protein 14HPRD00579
NP_005219.12888NP_004481.1growth factor receptor-bound protein 14HPRD03313
NP_005219.16633NP_004588.1small nuclear ribonucleoprotein polypeptide D2HPRD03038
NP_005219.16633NP_004588.1small nuclear ribonucleoprotein polypeptide D2HPRD00579
NP_005219.12887NP_005302.2growth factor receptor-bound protein 10HPRD00579
NP_005219.12887NP_005302.2growth factor receptor-bound protein 10HPRD03312
NP_005219.17409NP_005419.2vav 1 oncogeneHPRD01284
NP_005219.17409NP_005419.2vav 1 oncogeneHPRD00579
NP_005219.110045NP_005481.1SH2 domain containing 3AHPRD00579
NP_005219.110045NP_005481.1SH2 domain containing 3AHPRD05283
NP_005219.13855NP_005547.2keratin 7HPRD01014
NP_005219.13855NP_005547.2keratin 7HPRD00579
NP_005219.14690NP_006144.1NCK adaptor protein 1HPRD02740
NP_005219.14690NP_006144.1NCK adaptor protein 1HPRD00579
NP_005219.16772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
NP_005219.16772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD00579
NP_005219.123624NP_036248.2Cas-Br-M (murine) ecotropic retroviral transforming sequence cHPRD00579
NP_005219.123624NP_036248.2Cas-Br-M (murine) ecotropic retroviral transforming sequence cHPRD09765
NP_005219.16777NP_036580.2signal transducer and activator of transcription 5BHPRD00579
NP_005219.16777NP_036580.2signal transducer and activator of transcription 5BHPRD05037
NP_005219.123214NP_055986.1exportin 6HPRD10525
NP_005219.153358NP_058544.2src homology 2 domain containing transforming protein C3HPRD12005
NP_005219.153358NP_058544.2src homology 2 domain containing transforming protein C3HPRD00579
NP_005219.15359NP_066928.1phospholipid scramblase 1HPRD00579
NP_005219.15359NP_066928.1phospholipid scramblase 1HPRD00579
NP_005219.183481NP_112598.1epiplakin 1HPRD06500
NP_005219.183481NP_112598.1epiplakin 1HPRD00579
NP_005219.158533NP_689419.1sorting nexin 6 isoform bHPRD12086
NP_005219.158533NP_689419.1sorting nexin 6 isoform bHPRD00579
NP_005219.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD00579
NP_005219.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_005219.15339NP_958782.1plectin 1 isoform 6HPRD00579
NP_005219.15339NP_958782.1plectin 1 isoform 6HPRD03180
NP_005219.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD01152
NP_005219.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD00579
NP_005219.2---BIND123348
NP_005219.22064--BIND197186
NP_005219.22885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND128216
NP_005219.25058NP_002567.3p21-activated kinase 1BIND123304
NP_005219.25335NP_002651.2phospholipase C gamma 1 isoform aBIND64773
NP_005219.25338NP_002654.2phospholipase D2BIND126457
NP_005219.25921NP_002881.1RAS p21 protein activator 1 isoform 1BIND57650
NP_005219.26464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND126351
NP_005219.26464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND57903
NP_005219.26464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND57973
NP_005219.27410NP_003362.2vav 2 oncogeneBIND123305
NP_005219.25296NP_005018.1phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)BIND126459
NP_005219.21956NP_005219.2epidermal growth factor receptor isoform aBIND150971
NP_005219.23320NP_005339.2heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2BIND123277
NP_005219.26774NP_644805.1signal transducer and activator of transcription 3 isoform 1BIND58094
NP_005219.25295NP_852664.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1BIND130445
NP_005219.24582NP_877418.1mucin 1, transmembraneBIND134117
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1956IPR000494EGF_rcpt_LEGF receptor, L domain
1956IPR006211Furin-likeFurin-like cysteine rich region
1956EGFR_HUMANP00533IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
1956EGFR_HUMANP00533IPR000494EGF_rcpt_LEGF receptor, L domain
1956EGFR_HUMANP00533IPR006211Furin-likeFurin-like cysteine rich region
1956EGFR_HUMANP00533IPR000719Prot_kinaseProtein kinase
1956EGFR_HUMANP00533IPR001245Tyr_pkinaseTyrosine protein kinase
1956EGFR_HUMANP00533IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
1956EGFR_HUMANP00533IPR013695WAKWall-associated kinase

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