Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1958
Official Symbol:EGR1
Other Aliases:AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225
See related:HGNC:3238|MIM:128990|HPRD:00549
Chromosome:5
Location:5q31.1
Gene Description:early growth response 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0312
ORGANISM:human
Entrez Gene ID:1958
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13653
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0557
ORGANISM:human
Entrez Gene ID:1958
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24330
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13653CBCerebellum37.211091995239350.0154285430908
13653CTXCerebral cortex100.0100.0
13653HIPHippocampal region58.0185489654541100.0
13653HPFHippocampal formation82.5657844543457100.0
13653HYHypothalamus47.401767730712951.2525177001953
13653LSXLateral septal complex100.0100.0
13653MBMidbrain55.614622116088965.6612854003906
13653MYMedulla27.657551765441932.5962057113647
13653OLFOlfactory bulb100.0100.0
13653PPons31.091339111328135.9311656951904
13653PALPallidum41.397571563720750.9998893737793
13653RHPRetrohippocampal region100.0100.0
13653sAMYStriatum-like amygdalar nuclei83.2248611450195100.0
13653STRStriatum100.0100.0
13653STRdStriatum dorsal region100.0100.0
13653STRvStriatum ventral region100.0100.0
13653THThalamus47.398178100585949.2807731628418
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1958GO:0003700TASFunctiontranscription factor activity
1958GO:0005634IEAComponentnucleus
1958GO:0006350IEAProcesstranscription
1958GO:0006355IEAProcessregulation of transcription, DNA-dependent
1958GO:0008270IEAFunctionzinc ion binding
1958GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-2033NP_001420.1E1A binding protein p300HPRD04078
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
-4664NP_005957.2NGFI-A binding protein 1HPRD02881
-4665NP_005958.1NGFI-A binding protein 2HPRD03854
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
AJ243425.12033NP_001420.1E1A binding protein p300BIND149069
AJ243425.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND197322
NP_001955.1--PRC8HPRD00549
NP_001955.1-AL080243.21Human DNA sequence from clone RP11-12M9 on chromosome 22BIND149066
NP_001955.14664-NGFIA binding proteinHPRD00549
NP_001955.14665-NGFIA binding protein 2HPRD00549
NP_001955.12033-E1A binding protein p300HPRD00549
NP_001955.15970-NFKB3HPRD00549
NP_001955.17157-p53HPRD00549
NP_001955.13725-c JunHPRD00549
NP_001955.16667AAF67726.1Homo sapiens transcription specificity factor Sp1 mRNA, partial cds.BIND19294
NP_001955.14616AF533019.1Homo sapiens growth arrest and DNA-damage-inducible, beta (GADD45B) gene, complete cds.BIND197321
NP_001955.12033NP_001420.1E1A binding protein p300BIND149067
NP_001955.15307NP_002644.3paired-like homeodomain transcription factor 1HPRD03688
NP_001955.15307NP_002644.3paired-like homeodomain transcription factor 1HPRD00549
NP_001955.14773NP_775114.1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform CHPRD02730
NP_001955.14773NP_775114.1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform CHPRD00549
NP_001955.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1958EGR1_HUMANP18146IPR001151GPR6_rcptGPR6 orphan receptor
1958EGR1_HUMANP18146IPR005398Tubby_NTubby protein, N-terminal
1958EGR1_HUMANP18146IPR007087Znf_C2H2Zinc finger, C2H2-type
1958EGR1_HUMANP18146IPR007086Znf_C2H2_subZinc finger, C2H2-subtype

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