Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:1977
Official Symbol:EIF4E
Other Aliases:CBP|EIF4EL1|EIF4F|MGC111573
See related:HGNC:3287|MIM:133440|HPRD:00591
Chromosome:4
Location:4q21-q25
Gene Description:eukaryotic translation initiation factor 4E
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0374
ORGANISM:human
Entrez Gene ID:1977
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:117045
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13684CBCerebellum10.258563995361310.9530639648438
13684CTXCerebral cortex24.137729644775416.908763885498
13684HIPHippocampal region18.737468719482419.649356842041
13684HPFHippocampal formation17.919630050659216.9696216583252
13684HYHypothalamus3.178813457489012.63186144828796
13684LSXLateral septal complex3.183611154556272.38812732696533
13684MBMidbrain11.194246292114310.0484657287598
13684MYMedulla11.696651458740212.8772830963135
13684OLFOlfactory bulb17.668638229370113.9788370132446
13684PPons9.5980424880981410.5433874130249
13684PALPallidum3.441167593002322.93371248245239
13684RHPRetrohippocampal region17.028799057006813.5878305435181
13684sAMYStriatum-like amygdalar nuclei4.274241447448732.47128653526306
13684STRStriatum4.133324146270752.85434293746948
13684STRdStriatum dorsal region3.516761541366582.54517292976379
13684STRvStriatum ventral region6.33591127395634.00589656829834
13684THThalamus8.17882156372076.95347785949707
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
1977GO:0000339TASFunctionRNA cap binding
1977GO:0003743TASFunctiontranslation initiation factor activity
1977GO:0005515IPIFunctionprotein binding
1977GO:0006413IEAProcesstranslational initiation
1977GO:0006445IEAProcessregulation of translation
1977GO:0016281TASComponenteukaryotic translation initiation factor 4F complex
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1982NP_001409.1eukaryotic translation initiation factor 4 gamma, 2HPRD09084
-8637NP_003723.1eukaryotic translation initiation factor 4E binding protein 3HPRD09149
-1978NP_004086.1eukaryotic translation initiation factor 4E binding protein 1HPRD03746
-1979NP_004087.1eukaryotic translation initiation factor 4E binding protein 2HPRD03747
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
-1981NP_886553.2eukaryotic translation initiation factor 4 gamma, 1 isoform 1HPRD06774
NP_001959.1--eIF4BHPRD00591
NP_001959.1--PHAS-IIHPRD00591
NP_001959.1--EIF4EBP3HPRD00591
NP_001959.1--EIF4ENIF1HPRD00591
NP_001959.1---BIND315559
NP_001959.11979-Eukaryotic translation initiation factor 4E binding protein 2HPRD00591
NP_001959.11982-EIF4G2HPRD00591
NP_001959.11981-eIF 4G1HPRD00591
NP_001959.15371-PMLHPRD00591
NP_001959.11978-Eukaryotic translation initiation factor 4E binding protein 1HPRD00591
NP_001959.18637-eIF4E binding protein 3HPRD00591
NP_001959.11981--BIND315390
NP_001959.18569BAA19885.1MNK1BIND194848
NP_001959.18672NP_003751.2eukaryotic translation initiation factor 4 gamma, 3HPRD00591
NP_001959.18672NP_003751.2eukaryotic translation initiation factor 4 gamma, 3HPRD06802
NP_001959.11978NP_004086.1eukaryotic translation initiation factor 4E binding protein 1BIND258831
NP_001959.11981NP_004944.2eukaryotic translation initiation factor 4 gamma, 1 isoform 4BIND194849
NP_001959.156478NP_062817.1eukaryotic translation initiation factor 4E nuclear import factor 1HPRD10456
NP_001959.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD00591
NP_001959.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD09467
NP_001959.11981NP_886553.2eukaryotic translation initiation factor 4 gamma, 1 isoform 1BIND181822
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
1977IF4E_HUMANP06730IPR001040TIF_eIF_4EEukaryotic translation initiation factor 4E (eIF-4E)

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