Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2017
Official Symbol:CTTN
Other Aliases:EMS1|FLJ34459
See related:HGNC:3338|MIM:164765|HPRD:01268
Chromosome:11
Location:11q13
Gene Description:cortactin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0506
ORGANISM:human
Entrez Gene ID:2017
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:60465
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13043CBCerebellum29.352665901184150.8015060424805
13043CTXCerebral cortex83.555664062582.7039909362793
13043HIPHippocampal region100.0100.0
13043HPFHippocampal formation100.0100.0
13043HYHypothalamus49.564798355102544.4780073165894
13043LSXLateral septal complex60.459750175476160.0398845672607
13043MBMidbrain52.808725357055754.1606006622314
13043MYMedulla55.157770156860472.5117797851562
13043OLFOlfactory bulb64.188670158386265.6817207336426
13043PPons52.369262695312563.4879093170166
13043PALPallidum42.968439102172943.5167303085327
13043RHPRetrohippocampal region78.261423110961978.1430225372314
13043sAMYStriatum-like amygdalar nuclei55.604645729064947.3805084228516
13043STRStriatum38.457068443298331.9342999458313
13043STRdStriatum dorsal region32.199918508529726.1774160861969
13043STRvStriatum ventral region35.406462669372628.3559260368347
13043THThalamus66.689462661743266.1266326904297
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2017GO:0001726ISSComponentruffle
2017GO:0005515ISSFunctionprotein binding
2017GO:0005625TASComponentsoluble fraction
2017GO:0005856TASComponentcytoskeleton
2017GO:0005938ISSComponentcell cortex
2017GO:0030027ISSComponentlamellipodium
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829NP_002850.1paxillinBIND217916
-6850NP_003168.2spleen tyrosine kinaseHPRD02514
-7082NP_003248.2tight junction protein 1 isoform aHPRD03002
-2245NP_004454.1faciogenital dysplasia proteinHPRD02373
-10096NP_005712.1ARP3 actin-related protein 3 homologHPRD05024
-22941NP_036441.1SH3 and multiple ankyrin repeat domains 2 isoform 1HPRD04479
-50807NP_060952.2development and differentiation enhancing factor 1BIND217908
-4638NP_444253.1myosin light chain kinase isoform 1HPRD02952
NP_005222.2--F-actinHPRD01268
NP_005222.2--CBP90HPRD01268
NP_005222.2--ZO-1HPRD01268
NP_005222.2--WIPHPRD01268
NP_005222.26850-SYKHPRD01268
NP_005222.22241-FERHPRD01268
NP_005222.222941-SH3 and multiple ankyrin repeat domains 2HPRD01268
NP_005222.27082-Tight junction protein 1HPRD01268
NP_005222.28976-Neural Wiskott Aldrich syndrome proteinHPRD01268
NP_005222.23737-Potassium voltage gated channel subfamily A member 2HPRD01268
NP_005222.210096-Actin related protein 3HPRD01268
NP_005222.24638-Myosin light chain kinaseHPRD01268
NP_005222.24638-Myosin light chain kinase, smooth muscle and non-muscle isozymesHPRD01268
NP_005222.27456-WASP interacting proteinHPRD01268
NP_005222.22245-Faciogenital dysplasia proteinHPRD01268
NP_005222.223779AAN40769.1Homo sapiens BCH domain-containing Cdc42GAP-like protein (BPGAP1) mRNA, complete cds.BIND295224
NP_005222.22885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_005222.22885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD01268
NP_005222.29672NP_055469.1syndecan 3HPRD01268
NP_005222.29672NP_055469.1syndecan 3HPRD01719
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2017IPR003134Hs1_CortactinHs1/Cortactin
2017IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
2017IPR001452SH3Src homology-3
2017IPR011511SH3_2Variant SH3
2017SRC8_HUMANQ14247IPR003134Hs1_CortactinHs1/Cortactin
2017SRC8_HUMANQ14247IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
2017SRC8_HUMANQ14247IPR001452SH3Src homology-3
2017SRC8_HUMANQ14247IPR011511SH3_2Variant SH3

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