Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2026
Official Symbol:ENO2
Other Aliases:NSE
See related:HGNC:3353|MIM:131360|HPRD:00573
Chromosome:12
Location:12p13
Gene Description:enolase 2 (gamma, neuronal)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0508
ORGANISM:human
Entrez Gene ID:2026
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24334
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0101
ORGANISM:human
Entrez Gene ID:2026
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.70 :: 2.03 :: 3.48 :: 3.06 :: -3.05 :: -3.23 :: -3.37
KARG Evidence 3
KARG ID:EVIP0211
ORGANISM:human
Entrez Gene ID:2026
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.41
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13807CBCerebellum50.050.0
13807CTXCerebral cortex50.050.0
13807HIPHippocampal region50.050.0
13807HPFHippocampal formation50.050.0
13807HYHypothalamus50.050.0
13807LSXLateral septal complex50.050.0
13807MBMidbrain50.050.0
13807MYMedulla50.050.0
13807OLFOlfactory bulb50.050.0
13807PPons50.050.0
13807PALPallidum50.050.0
13807RHPRetrohippocampal region50.050.0
13807sAMYStriatum-like amygdalar nuclei50.050.0
13807STRStriatum50.050.0
13807STRdStriatum dorsal region50.050.0
13807STRvStriatum ventral region50.050.0
13807THThalamus50.050.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2026GO:0000015IEAComponentphosphopyruvate hydratase complex
2026GO:0000287IEAFunctionmagnesium ion binding
2026GO:0004634TASFunctionphosphopyruvate hydratase activity
2026GO:0006096IEAProcessglycolysis
2026GO:0016829IEAFunctionlyase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2026ENOG_HUMANP09104IPR000941EnolaseEnolase

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