Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:203
Official Symbol:AK1
Other Aliases:-
See related:HGNC:361|MIM:103000|HPRD:00046
Chromosome:9
Location:9q34.1
Gene Description:adenylate kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0047
ORGANISM:human
Entrez Gene ID:203
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:0.05 :: -0.19 :: -0.30 :: 0.15 :: -0.42 :: 0.82 :: -0.31 :: -0.34 :: -0.47 :: -0.32
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11636CBCerebellum39.991834640502975.1869583129883
11636CTXCerebral cortex100.0100.0
11636HIPHippocampal region89.8474655151367100.0
11636HPFHippocampal formation99.5709915161133100.0
11636HYHypothalamus92.83606719970794.6801300048828
11636LSXLateral septal complex96.902561187744190.0968475341797
11636MBMidbrain85.260395050048893.618824005127
11636MYMedulla85.1691856384277100.0
11636OLFOlfactory bulb100.0100.0
11636PPons85.3464164733887100.0
11636PALPallidum93.3264083862305100.0
11636RHPRetrohippocampal region100.0100.0
11636sAMYStriatum-like amygdalar nuclei96.766597747802797.3525352478027
11636STRStriatum97.029552459716890.1699829101562
11636STRdStriatum dorsal region86.588668823242277.3388824462891
11636STRvStriatum ventral region100.099.1291313171387
11636THThalamus99.535758972168100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
203GO:0000166IEAFunctionnucleotide binding
203GO:0004017IEAFunctionadenylate kinase activity
203GO:0004017TASFunctionadenylate kinase activity
203GO:0005524IEAFunctionATP binding
203GO:0005737IEAComponentcytoplasm
203GO:0005829NRComponentcytosol
203GO:0006139IEAProcessnucleobase, nucleoside, nucleotide and nucleic acid metabolism
203GO:0016301IEAFunctionkinase activity
203GO:0016740IEAFunctiontransferase activity
203GO:0046034IEAProcessATP metabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2274NP_001441.2four and a half LIM domains 2HPRD04026
NP_000467.12274-FHL2HPRD00046
NP_000467.12274--BIND217760
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
203KAD1_HUMANP00568IPR000850Adenylate_kinAdenylate kinase
203KAD1_HUMANP00568IPR000623Shik_kinaseShikimate kinase

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